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Q5ZKD4

- NPL_CHICK

UniProt

Q5ZKD4 - NPL_CHICK

Protein

N-acetylneuraminate lyase

Gene

NPL

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway By similarity.By similarity

    Catalytic activityi

    N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei142 – 1421Involved in proton transfer during cleavageBy similarity
    Active sitei172 – 1721Schiff-base intermediate with substrateBy similarity

    GO - Molecular functioni

    1. N-acetylneuraminate lyase activity Source: UniProtKB

    GO - Biological processi

    1. carbohydrate metabolic process Source: UniProtKB-KW
    2. N-acetylneuraminate catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Carbohydrate metabolism

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    UniPathwayiUPA00629.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-acetylneuraminate lyase (EC:4.1.3.3)
    Short name:
    NALase
    Alternative name(s):
    N-acetylneuraminate pyruvate-lyase
    N-acetylneuraminic acid aldolase
    Sialate lyase
    Sialate-pyruvate lyase
    Sialic acid aldolase
    Sialic acid lyase
    Gene namesi
    Name:NPL
    ORF Names:RCJMB04_11j23
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 308308N-acetylneuraminate lyasePRO_0000273357Add
    BLAST

    Proteomic databases

    PaxDbiQ5ZKD4.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000038643.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5ZKD4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni50 – 512Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the DapA family. NanA subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0329.
    HOGENOMiHOG000218206.
    HOVERGENiHBG082055.
    KOiK01639.
    PhylomeDBiQ5ZKD4.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR002220. DapA-like.
    [Graphical view]
    PANTHERiPTHR12128. PTHR12128. 1 hit.
    PfamiPF00701. DHDPS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001365. DHDPS. 1 hit.
    PRINTSiPR00146. DHPICSNTHASE.

    Sequencei

    Sequence statusi: Complete.

    Q5ZKD4-1 [UniParc]FASTAAdd to Basket

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    MTPRKKLEGL VAATVTPMTP DGRINLSVIH QYVDYLVSEQ NVKNIFVNGT    50
    TGEGLSLSIQ ERKQLAEEWM CQGKGKLDHV IIHVGALSLL ESQELARHAA 100
    AIGASGIAVI APSFFKPTNK DELLGFLQKV ASEAPTVPFY YYHIPAMTGV 150
    KIRVEELLDG IREQIPTFQG VKFSDTDLLD LAQCINKKER EQFVFLYGVD 200
    EQLLSALAIG ANGAVGSTYN YLGRKTNLML QAFAKPDLAL ARKYQFLTGE 250
    FLSFVIKLGF GVAQTKAVMT SISGIPMGPP RLPLVGASEE FIAKAKAKLE 300
    SIVWPDGD 308
    Length:308
    Mass (Da):33,646
    Last modified:November 23, 2004 - v1
    Checksum:iFBA9375250252359
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ720150 mRNA. Translation: CAG31809.1.
    RefSeqiNP_001026731.1. NM_001031560.2.
    UniGeneiGga.22620.

    Genome annotation databases

    GeneIDi429074.
    KEGGigga:429074.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ720150 mRNA. Translation: CAG31809.1 .
    RefSeqi NP_001026731.1. NM_001031560.2.
    UniGenei Gga.22620.

    3D structure databases

    ProteinModelPortali Q5ZKD4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000038643.

    Proteomic databases

    PaxDbi Q5ZKD4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 429074.
    KEGGi gga:429074.

    Organism-specific databases

    CTDi 80896.

    Phylogenomic databases

    eggNOGi COG0329.
    HOGENOMi HOG000218206.
    HOVERGENi HBG082055.
    KOi K01639.
    PhylomeDBi Q5ZKD4.

    Enzyme and pathway databases

    UniPathwayi UPA00629 .

    Miscellaneous databases

    NextBioi 20829905.
    PROi Q5ZKD4.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR002220. DapA-like.
    [Graphical view ]
    PANTHERi PTHR12128. PTHR12128. 1 hit.
    Pfami PF00701. DHDPS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001365. DHDPS. 1 hit.
    PRINTSi PR00146. DHPICSNTHASE.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: CB.
      Tissue: Bursa of Fabricius.

    Entry informationi

    Entry nameiNPL_CHICK
    AccessioniPrimary (citable) accession number: Q5ZKD4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3