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Protein

14-3-3 protein zeta

Gene

YWHAZ

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-GGA-1445148. Translocation of GLUT4 to the plasma membrane.
R-GGA-3769402. Deactivation of the beta-catenin transactivating complex.
R-GGA-392517. Rap1 signalling.
R-GGA-430116. GP1b-IX-V activation signalling.
R-GGA-512988. Interleukin-3, 5 and GM-CSF signaling.
R-GGA-5628897. TP53 Regulates Metabolic Genes.

Names & Taxonomyi

Protein namesi
Recommended name:
14-3-3 protein zeta
Gene namesi
Name:YWHAZ
ORF Names:RCJMB04_11l21
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 24524514-3-3 protein zetaPRO_0000058632Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei184 – 1841PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5ZKC9.
PRIDEiQ5ZKC9.

Interactioni

Subunit structurei

Homodimer.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei56 – 561Interaction with phosphoserine on interacting proteinBy similarity
Sitei127 – 1271Interaction with phosphoserine on interacting proteinBy similarity

Protein-protein interaction databases

BioGridi685627. 2 interactions.
IntActiQ5ZKC9. 1 interaction.
STRINGi9031.ENSGALP00000028746.

Structurei

3D structure databases

ProteinModelPortaliQ5ZKC9.
SMRiQ5ZKC9. Positions 1-232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 14-3-3 family.Curated

Phylogenomic databases

eggNOGiKOG0841. Eukaryota.
COG5040. LUCA.
GeneTreeiENSGT00760000119116.
HOGENOMiHOG000240379.
HOVERGENiHBG050423.
InParanoidiQ5ZKC9.
KOiK16197.
OMAiKESALIM.
OrthoDBiEOG7HHWT3.
PhylomeDBiQ5ZKC9.
TreeFamiTF102003.

Family and domain databases

InterProiIPR000308. 14-3-3.
IPR023409. 14-3-3_CS.
IPR023410. 14-3-3_domain.
[Graphical view]
PANTHERiPTHR18860. PTHR18860. 1 hit.
PfamiPF00244. 14-3-3. 1 hit.
[Graphical view]
PIRSFiPIRSF000868. 14-3-3. 1 hit.
PRINTSiPR00305. 1433ZETA.
SMARTiSM00101. 14_3_3. 1 hit.
[Graphical view]
SUPFAMiSSF48445. SSF48445. 1 hit.
PROSITEiPS00796. 1433_1. 1 hit.
PS00797. 1433_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZKC9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKNELVQKA KLAEQAERYD DMASCMKSVT EQGAELSNEE RNLLSVAYKN
60 70 80 90 100
VVGARRSSWR VVSSIEQKTE GAEKKQQMAR EYREKIETEL RDICNDVLSL
110 120 130 140 150
LEKFLIPNAS QAESKVFYLK MKGDYYRYLA EVAAGDDKKG IVEQSQQAYQ
160 170 180 190 200
EAFEISKKEM QPTHPIRLGL ALNFSVFYYE ILNSPEKACS LAKTAFDEAI
210 220 230 240
AELDTLSEES YKDSTLIMQL LRDNLTLWTS DTQGDEAEAG EGGEN
Length:245
Mass (Da):27,775
Last modified:November 23, 2004 - v1
Checksum:iF2A813EE4B23B42D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720155 mRNA. Translation: CAG31814.1.
RefSeqiNP_001026514.1. NM_001031343.1.
UniGeneiGga.8276.

Genome annotation databases

EnsembliENSGALT00000029403; ENSGALP00000028746; ENSGALG00000010725.
GeneIDi425619.
KEGGigga:425619.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720155 mRNA. Translation: CAG31814.1.
RefSeqiNP_001026514.1. NM_001031343.1.
UniGeneiGga.8276.

3D structure databases

ProteinModelPortaliQ5ZKC9.
SMRiQ5ZKC9. Positions 1-232.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi685627. 2 interactions.
IntActiQ5ZKC9. 1 interaction.
STRINGi9031.ENSGALP00000028746.

Proteomic databases

PaxDbiQ5ZKC9.
PRIDEiQ5ZKC9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000029403; ENSGALP00000028746; ENSGALG00000010725.
GeneIDi425619.
KEGGigga:425619.

Organism-specific databases

CTDi7534.

Phylogenomic databases

eggNOGiKOG0841. Eukaryota.
COG5040. LUCA.
GeneTreeiENSGT00760000119116.
HOGENOMiHOG000240379.
HOVERGENiHBG050423.
InParanoidiQ5ZKC9.
KOiK16197.
OMAiKESALIM.
OrthoDBiEOG7HHWT3.
PhylomeDBiQ5ZKC9.
TreeFamiTF102003.

Enzyme and pathway databases

ReactomeiR-GGA-1445148. Translocation of GLUT4 to the plasma membrane.
R-GGA-3769402. Deactivation of the beta-catenin transactivating complex.
R-GGA-392517. Rap1 signalling.
R-GGA-430116. GP1b-IX-V activation signalling.
R-GGA-512988. Interleukin-3, 5 and GM-CSF signaling.
R-GGA-5628897. TP53 Regulates Metabolic Genes.

Miscellaneous databases

NextBioi20827573.
PROiQ5ZKC9.

Family and domain databases

InterProiIPR000308. 14-3-3.
IPR023409. 14-3-3_CS.
IPR023410. 14-3-3_domain.
[Graphical view]
PANTHERiPTHR18860. PTHR18860. 1 hit.
PfamiPF00244. 14-3-3. 1 hit.
[Graphical view]
PIRSFiPIRSF000868. 14-3-3. 1 hit.
PRINTSiPR00305. 1433ZETA.
SMARTiSM00101. 14_3_3. 1 hit.
[Graphical view]
SUPFAMiSSF48445. SSF48445. 1 hit.
PROSITEiPS00796. 1433_1. 1 hit.
PS00797. 1433_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry namei1433Z_CHICK
AccessioniPrimary (citable) accession number: Q5ZKC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 23, 2004
Last modified: December 9, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.