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Protein

Probable cation-transporting ATPase 13A4

Gene

ATP13A4

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei4834-aspartylphosphate intermediateBy similarity1
Metal bindingi845MagnesiumBy similarity1
Metal bindingi849MagnesiumBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cation-transporting ATPase 13A4 (EC:3.6.3.-)
Alternative name(s):
P5-ATPase isoform 4
Gene namesi
Name:ATP13A4
ORF Names:RCJMB04_11o9
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32CytoplasmicSequence analysisAdd BLAST32
Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Topological domaini54 – 219ExtracellularSequence analysisAdd BLAST166
Transmembranei220 – 242HelicalSequence analysisAdd BLAST23
Topological domaini243 – 397CytoplasmicSequence analysisAdd BLAST155
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Topological domaini419 – 433ExtracellularSequence analysisAdd BLAST15
Transmembranei434 – 454HelicalSequence analysisAdd BLAST21
Topological domaini455 – 897CytoplasmicSequence analysisAdd BLAST443
Transmembranei898 – 918HelicalSequence analysisAdd BLAST21
Topological domaini919 – 929ExtracellularSequence analysisAdd BLAST11
Transmembranei930 – 950HelicalSequence analysisAdd BLAST21
Topological domaini951 – 967CytoplasmicSequence analysisAdd BLAST17
Transmembranei968 – 988HelicalSequence analysisAdd BLAST21
Topological domaini989 – 1043ExtracellularSequence analysisAdd BLAST55
Transmembranei1044 – 1064HelicalSequence analysisAdd BLAST21
Topological domaini1065 – 1075CytoplasmicSequence analysisAdd BLAST11
Transmembranei1076 – 1096HelicalSequence analysisAdd BLAST21
Topological domaini1097 – 1113ExtracellularSequence analysisAdd BLAST17
Transmembranei1114 – 1134HelicalSequence analysisAdd BLAST21
Topological domaini1135 – 1204CytoplasmicSequence analysisAdd BLAST70

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003186771 – 1204Probable cation-transporting ATPase 13A4Add BLAST1204

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5ZKB7.
PRIDEiQ5ZKB7.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011610.

Structurei

3D structure databases

ProteinModelPortaliQ5ZKB7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0208. Eukaryota.
ENOG410XRCA. LUCA.
HOGENOMiHOG000171813.
HOVERGENiHBG065757.
InParanoidiQ5ZKB7.
KOiK14951.
PhylomeDBiQ5ZKB7.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006544. P-type_TPase_V.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF12409. P5-ATPase. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01494. ATPase_P-type. 3 hits.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZKB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGENPAKSHY AQLNLGEENE MEIFGYKTQC CRKALCIAGY ILSCGALLLL
60 70 80 90 100
FYWKPEWDVW ANCVPCSLEE ADVVLLRTTD EFRIYSRKNV TWISVSGIIK
110 120 130 140 150
SRLDYPSFAE EDSIFSKALM KPSLQVKSIQ VQKIRYVWNI YAKQFQKVGA
160 170 180 190 200
LEDHHTCSAI HTKFGSGLTC SEQSLRRVIC GPNTIDVPVI PIWKLLIKEV
210 220 230 240 250
LNPFYVFQLF SVCLWFAEDY MEYAAAIIIM SPLSISLTVY DLRQQSVKLQ
260 270 280 290 300
RLVESHNSIM VTGRNKEGFQ ELESHHLVPG DMVVLKEGKA LLPCDAILIS
310 320 330 340 350
GQCIVNESML TGESIPVTKT QLPQADNLKP WKMHCAEDYK KHVLFCGTEV
360 370 380 390 400
IQTKGDDRGV VKAVVLQTGF NTAKGDLVRS ILYPKPMNFR LYRDALRFLM
410 420 430 440 450
CLIAFAAIGM IYTVCVFALN GEEAGEVVKK ALDVITIAVP PALPAALTTG
460 470 480 490 500
IIYTQRRLKK KGIFCISPQR INMCGQLNLI CFDKTGTLTE DGLDLWGLLP
510 520 530 540 550
SEGNCFQDVR RFPADHSLPW GPAFRAMVVC HSLIVLEGKI QGDPLDVKMF
560 570 580 590 600
EATNWVIDDS SGHQIEGQRS THATVIRPGP KANTASVDGI TILHQFPFSS
610 620 630 640 650
ALQRMSVIAQ ETGGEKQAFT KGAPEMVATL CRAETVPSNF ESKLLFYTAQ
660 670 680 690 700
GFRVIGLAYK SLQSGKQSTD LTREEVESDL TFLGLLIMEN RLKRETKPVL
710 720 730 740 750
EELSAAHIRS VMVTGDNIQT AVTVAKNAGM ISPTNRVILV EANKIPGSFS
760 770 780 790 800
ASVTWKPLKE NKTEDDGNLD SGSQTGRRIR LAAEPGQFHF AMSGKSYQVV
810 820 830 840 850
AQYFSHLLPK LLLNATVFAR MSPSQKSSLV EEFQKLDYFV GMCGDGANDC
860 870 880 890 900
GALKVAHAGI SLSEQEASVA SPFTSRTPSI ACVPELIREG RAALVTSFCM
910 920 930 940 950
FKYMALYSTI QYLGVLLLYW QLNSFGNYQF LFQDLAITTV IGMTMSFTEA
960 970 980 990 1000
YPKLVPYRPP SQLVSPPLLL SVILNILFSL GMQILGFLMV QKQPWYSKTD
1010 1020 1030 1040 1050
IHSACLSVNN HVENSSSASS LGLHGVGGGD PTEVDNGYKS YENTTVWLLS
1060 1070 1080 1090 1100
TINCLIIALV FSKGKPFRQP IYTNYVFIMV LVGQLGVCLF LVFADIDDLY
1110 1120 1130 1140 1150
SKMDLVCTPT TWRISMVMML AVTLAVSFLV EEAIIENRAL WLWLKKTFQY
1160 1170 1180 1190 1200
HSKSHYKRLQ RVLEQDSAWP PLNETFSLDA VTVSVEEDME GHSNPTFDSN

EDAL
Length:1,204
Mass (Da):134,058
Last modified:November 23, 2004 - v1
Checksum:iB6AECD6FE30FFDEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720167 mRNA. Translation: CAG31826.1.
RefSeqiNP_001026485.1. NM_001031314.1.
UniGeneiGga.22189.

Genome annotation databases

GeneIDi424901.
KEGGigga:424901.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720167 mRNA. Translation: CAG31826.1.
RefSeqiNP_001026485.1. NM_001031314.1.
UniGeneiGga.22189.

3D structure databases

ProteinModelPortaliQ5ZKB7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011610.

Proteomic databases

PaxDbiQ5ZKB7.
PRIDEiQ5ZKB7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi424901.
KEGGigga:424901.

Organism-specific databases

CTDi84239.

Phylogenomic databases

eggNOGiKOG0208. Eukaryota.
ENOG410XRCA. LUCA.
HOGENOMiHOG000171813.
HOVERGENiHBG065757.
InParanoidiQ5ZKB7.
KOiK14951.
PhylomeDBiQ5ZKB7.

Miscellaneous databases

PROiQ5ZKB7.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006544. P-type_TPase_V.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF12409. P5-ATPase. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01494. ATPase_P-type. 3 hits.
TIGR01657. P-ATPase-V. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAT134_CHICK
AccessioniPrimary (citable) accession number: Q5ZKB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 23, 2004
Last modified: October 5, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.