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Protein

Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial

Gene

MTHFD2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Although its dehydrogenase activity is NAD-specific, it can also utilize NADP at a reduced efficiency.By similarity

Catalytic activityi

5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH.
5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei228NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi195 – 197NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Oxidoreductase
Biological processOne-carbon metabolism
LigandMagnesium, NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
Including the following 2 domains:
NAD-dependent methylenetetrahydrofolate dehydrogenase (EC:1.5.1.15)
Methenyltetrahydrofolate cyclohydrolase (EC:3.5.4.9)
Gene namesi
Name:MTHFD2
ORF Names:RCJMB04_12b8
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 30MitochondrionSequence analysisAdd BLAST30
ChainiPRO_000004288531 – 337Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrialAdd BLAST307

Proteomic databases

PaxDbiQ5ZKA5.

Interactioni

Protein-protein interaction databases

BioGridi685886. 1 interactor.
STRINGi9031.ENSGALP00000022034.

Structurei

3D structure databases

ProteinModelPortaliQ5ZKA5.
SMRiQ5ZKA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni79 – 83Substrate bindingBy similarity5
Regioni126 – 128Substrate bindingBy similarity3
Regioni304 – 308Substrate bindingBy similarity5

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0089. Eukaryota.
COG0190. LUCA.
HOGENOMiHOG000218242.
HOVERGENiHBG006411.
InParanoidiQ5ZKA5.
KOiK13403.
PhylomeDBiQ5ZKA5.

Family and domain databases

HAMAPiMF_01576. THF_DHG_CYH. 1 hit.
InterProiView protein in InterPro
IPR016040. NAD(P)-bd_dom.
IPR000672. THF_DH/CycHdrlase.
IPR020630. THF_DH/CycHdrlase_cat_dom.
IPR020867. THF_DH/CycHdrlase_CS.
IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
PANTHERiPTHR10025. PTHR10025. 1 hit.
PfamiView protein in Pfam
PF00763. THF_DHG_CYH. 1 hit.
PF02882. THF_DHG_CYH_C. 1 hit.
PRINTSiPR00085. THFDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00766. THF_DHG_CYH_1. 1 hit.
PS00767. THF_DHG_CYH_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ZKA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATALCPLRA LGQTAFRPRT RRLHLSAPRA DAVVISGRKL ARQIRQEARH
60 70 80 90 100
EVEQWVAAGN KRPHLSVVLV GENPASHSYV LNKTKAAADV GISSETILKP
110 120 130 140 150
ASITEEELLD LISKLNNDAN VDGLLVQLPL PEHIDERKIC NAVTPDKDVD
160 170 180 190 200
GFHVINVGRM CLDQYSMLPA TPWGVWEIIK RTGIPTLGKN VVVAGRSKNV
210 220 230 240 250
GMPIAMLLHT DGRHERPGGD ATVTISHRYT PKEQLKQHTI RADIVVAAAG
260 270 280 290 300
IPNLITADMI KEGAAVIDVG ITRVQDPITA KSRLVGDVDF EGVKKKASYI
310 320 330
TPVPGGVGPM TVAMLMKNTI IAAKKLLKPK ALEALTA
Length:337
Mass (Da):36,411
Last modified:November 23, 2004 - v1
Checksum:iCA3B321FC58F32CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720179 mRNA. Translation: CAG31838.1.
RefSeqiNP_001026531.1. NM_001031360.1.
UniGeneiGga.2672.

Genome annotation databases

GeneIDi426126.
KEGGigga:426126.

Similar proteinsi

Entry informationi

Entry nameiMTDC_CHICK
AccessioniPrimary (citable) accession number: Q5ZKA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 23, 2004
Last modified: August 30, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families