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Protein

Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial

Gene

MTHFD2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH.
5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.

Cofactori

Mg2+By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Oxidoreductase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

Magnesium, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
Including the following 2 domains:
NAD-dependent methylenetetrahydrofolate dehydrogenase (EC:1.5.1.15)
Methenyltetrahydrofolate cyclohydrolase (EC:3.5.4.9)
Gene namesi
Name:MTHFD2
ORF Names:RCJMB04_12b8
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 30MitochondrionSequence analysisAdd BLAST30
ChainiPRO_000004288531 – 337Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrialAdd BLAST307

Proteomic databases

PaxDbiQ5ZKA5.

Interactioni

Protein-protein interaction databases

BioGridi685886. 1 interactor.
STRINGi9031.ENSGALP00000022034.

Structurei

3D structure databases

ProteinModelPortaliQ5ZKA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0089. Eukaryota.
COG0190. LUCA.
HOGENOMiHOG000218242.
HOVERGENiHBG006411.
InParanoidiQ5ZKA5.
KOiK13403.
PhylomeDBiQ5ZKA5.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01576. THF_DHG_CYH. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000672. THF_DH/CycHdrlase.
IPR020630. THF_DH/CycHdrlase_cat_dom.
IPR020867. THF_DH/CycHdrlase_CS.
IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
[Graphical view]
PfamiPF00763. THF_DHG_CYH. 1 hit.
PF02882. THF_DHG_CYH_C. 1 hit.
[Graphical view]
PRINTSiPR00085. THFDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00766. THF_DHG_CYH_1. 1 hit.
PS00767. THF_DHG_CYH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ZKA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATALCPLRA LGQTAFRPRT RRLHLSAPRA DAVVISGRKL ARQIRQEARH
60 70 80 90 100
EVEQWVAAGN KRPHLSVVLV GENPASHSYV LNKTKAAADV GISSETILKP
110 120 130 140 150
ASITEEELLD LISKLNNDAN VDGLLVQLPL PEHIDERKIC NAVTPDKDVD
160 170 180 190 200
GFHVINVGRM CLDQYSMLPA TPWGVWEIIK RTGIPTLGKN VVVAGRSKNV
210 220 230 240 250
GMPIAMLLHT DGRHERPGGD ATVTISHRYT PKEQLKQHTI RADIVVAAAG
260 270 280 290 300
IPNLITADMI KEGAAVIDVG ITRVQDPITA KSRLVGDVDF EGVKKKASYI
310 320 330
TPVPGGVGPM TVAMLMKNTI IAAKKLLKPK ALEALTA
Length:337
Mass (Da):36,411
Last modified:November 23, 2004 - v1
Checksum:iCA3B321FC58F32CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720179 mRNA. Translation: CAG31838.1.
RefSeqiNP_001026531.1. NM_001031360.1.
UniGeneiGga.2672.

Genome annotation databases

GeneIDi426126.
KEGGigga:426126.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720179 mRNA. Translation: CAG31838.1.
RefSeqiNP_001026531.1. NM_001031360.1.
UniGeneiGga.2672.

3D structure databases

ProteinModelPortaliQ5ZKA5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi685886. 1 interactor.
STRINGi9031.ENSGALP00000022034.

Proteomic databases

PaxDbiQ5ZKA5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi426126.
KEGGigga:426126.

Organism-specific databases

CTDi10797.

Phylogenomic databases

eggNOGiKOG0089. Eukaryota.
COG0190. LUCA.
HOGENOMiHOG000218242.
HOVERGENiHBG006411.
InParanoidiQ5ZKA5.
KOiK13403.
PhylomeDBiQ5ZKA5.

Miscellaneous databases

PROiQ5ZKA5.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01576. THF_DHG_CYH. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000672. THF_DH/CycHdrlase.
IPR020630. THF_DH/CycHdrlase_cat_dom.
IPR020867. THF_DH/CycHdrlase_CS.
IPR020631. THF_DH/CycHdrlase_NAD-bd_dom.
[Graphical view]
PfamiPF00763. THF_DHG_CYH. 1 hit.
PF02882. THF_DHG_CYH_C. 1 hit.
[Graphical view]
PRINTSiPR00085. THFDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00766. THF_DHG_CYH_1. 1 hit.
PS00767. THF_DHG_CYH_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTDC_CHICK
AccessioniPrimary (citable) accession number: Q5ZKA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 23, 2004
Last modified: June 8, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.