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Q5ZKA2

- SYIM_CHICK

UniProt

Q5ZKA2 - SYIM_CHICK

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Protein

Isoleucine--tRNA ligase, mitochondrial

Gene
IARS2, RCJMB04_12b19
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei652 – 6521ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. isoleucine-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. isoleucyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Isoleucine--tRNA ligase, mitochondrial (EC:6.1.1.5)
Alternative name(s):
Isoleucyl-tRNA synthetase
Short name:
IleRS
Gene namesi
Name:IARS2
ORF Names:RCJMB04_12b19
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Mitochondrion matrix By similarity UniRule annotation

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2727Mitochondrion Reviewed predictionAdd
BLAST
Chaini28 – 1000973Isoleucine--tRNA ligase, mitochondrialUniRule annotationPRO_0000233338Add
BLAST

Proteomic databases

PaxDbiQ5ZKA2.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000037780.

Structurei

3D structure databases

ProteinModelPortaliQ5ZKA2.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi102 – 11211"HIGH" region By similarityAdd
BLAST
Motifi649 – 6535"KMSKS" region By similarity

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0060.
HOGENOMiHOG000246402.
HOVERGENiHBG059862.
InParanoidiQ5ZKA2.
KOiK01870.
PhylomeDBiQ5ZKA2.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_02002. Ile_tRNA_synth_type1.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002301. Ile-tRNA-ligase.
IPR023585. Ile-tRNA-ligase_type1.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF9. PTHR11946:SF9. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
PRINTSiPR00984. TRNASYNTHILE.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00392. ileS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ZKA2-1 [UniParc]FASTAAdd to Basket

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MLGAWRAAPR LRLRARFGVA SVWARSAASE ANSRRPAEES RQDSQYRDTV     50
LLPHSRFAAQ LPGRLQPDTE LETQQKSGFL ELYSWQRQRK AKQEFCLHDG 100
PPYANGDPHV GHALNKILKD ITNRFHMMRG YKVHYVPGWD CHGLPIELKA 150
LSEVKGAENL SPVEIRQKAK EFAERAIEKQ KAAFIRWGIM ADWANCYRTF 200
DPKYEANQLR VFHKMYDKGF IYQDYKPVFW SPSAKTALAE AELEYNEQHV 250
SRSVYMKFPL LKSPPKLASV IDGSSPASVL VWTTQPWTVP ANQAVCYMPD 300
AEYSVVKCAT TGEHLILAAD RVESTAAVLD TQFEVISTCK GVDLADGSCA 350
HPTIAGRVSP LLPANHVTMT KGTGLVHTAP AHGMEDYNVA SHHQLPTECL 400
VDESGHFTEA AGPELKNKNV LEEGNEAVIK MLQAAGSLLK EEKYVHSYPY 450
DWRTKKPMII RASKQWFVNT ANVKATAQEA LKKVKIIPTS AVNRMLEMLD 500
RRTFWCISRQ RCWGVPIPVF YQKDTGESLI NSETIADVIK IVEQQGTDAW 550
WTLPIEQLLS KEAVAKAGGH NVLDYVKGQD VLDIWFDSGT SWAHVLEGAE 600
QRADVYLEGK DQLGGWFQSS LLTSVATRKK APYKTLVVHG FTLGEKGEKM 650
SKSIGNVVDP DVVINGGDDH TKDPPYGADV LRWWVAESNV FTEVLIGPVV 700
LNAARDDINK LRNTLRFMLG NMAGFNPETD SIPPSEMYIV DQYMLHLLQD 750
YGSKVTEAYK EYDYSKVVRL LQAFCSRNLS NFYFSIIKDR LYCEEEKDPK 800
RRSCQTVLAE ALDVVVRSFA PILPHLAEEV FQHLPYKKDS EGVFRTGWIN 850
ASSGWKKPGI EEAIEGACAM RDSFLGSISG KNALEYEVII VIEPGLLFEL 900
MEALQAEESS RVSQLNEIMM ASQTTLLSEI PKETPADANI VKGNFLINLE 950
GGDIREESSY QVIALPTTKA KCPRCRRYTS DSSSTPCPRC LKVIAGKGST 1000
Length:1,000
Mass (Da):112,007
Last modified:November 23, 2004 - v1
Checksum:i4EC0778C2FFEB7ED
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ720182 mRNA. Translation: CAG31841.1.
RefSeqiNP_001006397.1. NM_001006397.1.
UniGeneiGga.7186.

Genome annotation databases

GeneIDi421346.
KEGGigga:421346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ720182 mRNA. Translation: CAG31841.1 .
RefSeqi NP_001006397.1. NM_001006397.1.
UniGenei Gga.7186.

3D structure databases

ProteinModelPortali Q5ZKA2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000037780.

Proteomic databases

PaxDbi Q5ZKA2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 421346.
KEGGi gga:421346.

Organism-specific databases

CTDi 55699.

Phylogenomic databases

eggNOGi COG0060.
HOGENOMi HOG000246402.
HOVERGENi HBG059862.
InParanoidi Q5ZKA2.
KOi K01870.
PhylomeDBi Q5ZKA2.

Miscellaneous databases

NextBioi 20824124.
PROi Q5ZKA2.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_02002. Ile_tRNA_synth_type1.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002301. Ile-tRNA-ligase.
IPR023585. Ile-tRNA-ligase_type1.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF9. PTHR11946:SF9. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view ]
PRINTSi PR00984. TRNASYNTHILE.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00392. ileS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiSYIM_CHICK
AccessioniPrimary (citable) accession number: Q5ZKA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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