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Q5ZKA2

- SYIM_CHICK

UniProt

Q5ZKA2 - SYIM_CHICK

Protein

Isoleucine--tRNA ligase, mitochondrial

Gene

IARS2

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei652 – 6521ATPBy similarity

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. isoleucine-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. isoleucyl-tRNA aminoacylation Source: InterPro

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isoleucine--tRNA ligase, mitochondrial (EC:6.1.1.5)
    Alternative name(s):
    Isoleucyl-tRNA synthetase
    Short name:
    IleRS
    Gene namesi
    Name:IARS2
    ORF Names:RCJMB04_12b19
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2727MitochondrionSequence AnalysisAdd
    BLAST
    Chaini28 – 1000973Isoleucine--tRNA ligase, mitochondrialPRO_0000233338Add
    BLAST

    Proteomic databases

    PaxDbiQ5ZKA2.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000037780.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5ZKA2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi102 – 11211"HIGH" regionBy similarityAdd
    BLAST
    Motifi649 – 6535"KMSKS" regionBy similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0060.
    HOGENOMiHOG000246402.
    HOVERGENiHBG059862.
    InParanoidiQ5ZKA2.
    KOiK01870.
    PhylomeDBiQ5ZKA2.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_02002. Ile_tRNA_synth_type1.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002301. Ile-tRNA-ligase.
    IPR023585. Ile-tRNA-ligase_type1.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF9. PTHR11946:SF9. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    [Graphical view]
    PRINTSiPR00984. TRNASYNTHILE.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00392. ileS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5ZKA2-1 [UniParc]FASTAAdd to Basket

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    MLGAWRAAPR LRLRARFGVA SVWARSAASE ANSRRPAEES RQDSQYRDTV     50
    LLPHSRFAAQ LPGRLQPDTE LETQQKSGFL ELYSWQRQRK AKQEFCLHDG 100
    PPYANGDPHV GHALNKILKD ITNRFHMMRG YKVHYVPGWD CHGLPIELKA 150
    LSEVKGAENL SPVEIRQKAK EFAERAIEKQ KAAFIRWGIM ADWANCYRTF 200
    DPKYEANQLR VFHKMYDKGF IYQDYKPVFW SPSAKTALAE AELEYNEQHV 250
    SRSVYMKFPL LKSPPKLASV IDGSSPASVL VWTTQPWTVP ANQAVCYMPD 300
    AEYSVVKCAT TGEHLILAAD RVESTAAVLD TQFEVISTCK GVDLADGSCA 350
    HPTIAGRVSP LLPANHVTMT KGTGLVHTAP AHGMEDYNVA SHHQLPTECL 400
    VDESGHFTEA AGPELKNKNV LEEGNEAVIK MLQAAGSLLK EEKYVHSYPY 450
    DWRTKKPMII RASKQWFVNT ANVKATAQEA LKKVKIIPTS AVNRMLEMLD 500
    RRTFWCISRQ RCWGVPIPVF YQKDTGESLI NSETIADVIK IVEQQGTDAW 550
    WTLPIEQLLS KEAVAKAGGH NVLDYVKGQD VLDIWFDSGT SWAHVLEGAE 600
    QRADVYLEGK DQLGGWFQSS LLTSVATRKK APYKTLVVHG FTLGEKGEKM 650
    SKSIGNVVDP DVVINGGDDH TKDPPYGADV LRWWVAESNV FTEVLIGPVV 700
    LNAARDDINK LRNTLRFMLG NMAGFNPETD SIPPSEMYIV DQYMLHLLQD 750
    YGSKVTEAYK EYDYSKVVRL LQAFCSRNLS NFYFSIIKDR LYCEEEKDPK 800
    RRSCQTVLAE ALDVVVRSFA PILPHLAEEV FQHLPYKKDS EGVFRTGWIN 850
    ASSGWKKPGI EEAIEGACAM RDSFLGSISG KNALEYEVII VIEPGLLFEL 900
    MEALQAEESS RVSQLNEIMM ASQTTLLSEI PKETPADANI VKGNFLINLE 950
    GGDIREESSY QVIALPTTKA KCPRCRRYTS DSSSTPCPRC LKVIAGKGST 1000
    Length:1,000
    Mass (Da):112,007
    Last modified:November 23, 2004 - v1
    Checksum:i4EC0778C2FFEB7ED
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ720182 mRNA. Translation: CAG31841.1.
    RefSeqiNP_001006397.1. NM_001006397.1.
    UniGeneiGga.7186.

    Genome annotation databases

    GeneIDi421346.
    KEGGigga:421346.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ720182 mRNA. Translation: CAG31841.1 .
    RefSeqi NP_001006397.1. NM_001006397.1.
    UniGenei Gga.7186.

    3D structure databases

    ProteinModelPortali Q5ZKA2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000037780.

    Proteomic databases

    PaxDbi Q5ZKA2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 421346.
    KEGGi gga:421346.

    Organism-specific databases

    CTDi 55699.

    Phylogenomic databases

    eggNOGi COG0060.
    HOGENOMi HOG000246402.
    HOVERGENi HBG059862.
    InParanoidi Q5ZKA2.
    KOi K01870.
    PhylomeDBi Q5ZKA2.

    Miscellaneous databases

    NextBioi 20824124.
    PROi Q5ZKA2.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 2 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_02002. Ile_tRNA_synth_type1.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002300. aa-tRNA-synth_Ia.
    IPR002301. Ile-tRNA-ligase.
    IPR023585. Ile-tRNA-ligase_type1.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF9. PTHR11946:SF9. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF00133. tRNA-synt_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00984. TRNASYNTHILE.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00392. ileS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: CB.
      Tissue: Bursa of Fabricius.

    Entry informationi

    Entry nameiSYIM_CHICK
    AccessioniPrimary (citable) accession number: Q5ZKA2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3