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Protein

Isoleucine--tRNA ligase, mitochondrial

Gene

IARS2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei652 – 6521ATPBy similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. isoleucine-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. isoleucyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Isoleucine--tRNA ligase, mitochondrial (EC:6.1.1.5)
Alternative name(s):
Isoleucyl-tRNA synthetase
Short name:
IleRS
Gene namesi
Name:IARS2
ORF Names:RCJMB04_12b19
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Unplaced

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2727MitochondrionSequence AnalysisAdd
BLAST
Chaini28 – 1000973Isoleucine--tRNA ligase, mitochondrialPRO_0000233338Add
BLAST

Proteomic databases

PaxDbiQ5ZKA2.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000037780.

Structurei

3D structure databases

ProteinModelPortaliQ5ZKA2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi102 – 11211"HIGH" regionBy similarityAdd
BLAST
Motifi649 – 6535"KMSKS" regionBy similarity

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0060.
HOGENOMiHOG000246402.
HOVERGENiHBG059862.
InParanoidiQ5ZKA2.
KOiK01870.
PhylomeDBiQ5ZKA2.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_02002. Ile_tRNA_synth_type1.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002301. Ile-tRNA-ligase.
IPR023585. Ile-tRNA-ligase_type1.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF9. PTHR11946:SF9. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
PRINTSiPR00984. TRNASYNTHILE.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00392. ileS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ZKA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGAWRAAPR LRLRARFGVA SVWARSAASE ANSRRPAEES RQDSQYRDTV
60 70 80 90 100
LLPHSRFAAQ LPGRLQPDTE LETQQKSGFL ELYSWQRQRK AKQEFCLHDG
110 120 130 140 150
PPYANGDPHV GHALNKILKD ITNRFHMMRG YKVHYVPGWD CHGLPIELKA
160 170 180 190 200
LSEVKGAENL SPVEIRQKAK EFAERAIEKQ KAAFIRWGIM ADWANCYRTF
210 220 230 240 250
DPKYEANQLR VFHKMYDKGF IYQDYKPVFW SPSAKTALAE AELEYNEQHV
260 270 280 290 300
SRSVYMKFPL LKSPPKLASV IDGSSPASVL VWTTQPWTVP ANQAVCYMPD
310 320 330 340 350
AEYSVVKCAT TGEHLILAAD RVESTAAVLD TQFEVISTCK GVDLADGSCA
360 370 380 390 400
HPTIAGRVSP LLPANHVTMT KGTGLVHTAP AHGMEDYNVA SHHQLPTECL
410 420 430 440 450
VDESGHFTEA AGPELKNKNV LEEGNEAVIK MLQAAGSLLK EEKYVHSYPY
460 470 480 490 500
DWRTKKPMII RASKQWFVNT ANVKATAQEA LKKVKIIPTS AVNRMLEMLD
510 520 530 540 550
RRTFWCISRQ RCWGVPIPVF YQKDTGESLI NSETIADVIK IVEQQGTDAW
560 570 580 590 600
WTLPIEQLLS KEAVAKAGGH NVLDYVKGQD VLDIWFDSGT SWAHVLEGAE
610 620 630 640 650
QRADVYLEGK DQLGGWFQSS LLTSVATRKK APYKTLVVHG FTLGEKGEKM
660 670 680 690 700
SKSIGNVVDP DVVINGGDDH TKDPPYGADV LRWWVAESNV FTEVLIGPVV
710 720 730 740 750
LNAARDDINK LRNTLRFMLG NMAGFNPETD SIPPSEMYIV DQYMLHLLQD
760 770 780 790 800
YGSKVTEAYK EYDYSKVVRL LQAFCSRNLS NFYFSIIKDR LYCEEEKDPK
810 820 830 840 850
RRSCQTVLAE ALDVVVRSFA PILPHLAEEV FQHLPYKKDS EGVFRTGWIN
860 870 880 890 900
ASSGWKKPGI EEAIEGACAM RDSFLGSISG KNALEYEVII VIEPGLLFEL
910 920 930 940 950
MEALQAEESS RVSQLNEIMM ASQTTLLSEI PKETPADANI VKGNFLINLE
960 970 980 990 1000
GGDIREESSY QVIALPTTKA KCPRCRRYTS DSSSTPCPRC LKVIAGKGST
Length:1,000
Mass (Da):112,007
Last modified:November 22, 2004 - v1
Checksum:i4EC0778C2FFEB7ED
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720182 mRNA. Translation: CAG31841.1.
RefSeqiNP_001006397.1. NM_001006397.1.
UniGeneiGga.7186.

Genome annotation databases

GeneIDi421346.
KEGGigga:421346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720182 mRNA. Translation: CAG31841.1.
RefSeqiNP_001006397.1. NM_001006397.1.
UniGeneiGga.7186.

3D structure databases

ProteinModelPortaliQ5ZKA2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000037780.

Proteomic databases

PaxDbiQ5ZKA2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi421346.
KEGGigga:421346.

Organism-specific databases

CTDi55699.

Phylogenomic databases

eggNOGiCOG0060.
HOGENOMiHOG000246402.
HOVERGENiHBG059862.
InParanoidiQ5ZKA2.
KOiK01870.
PhylomeDBiQ5ZKA2.

Miscellaneous databases

NextBioi20824124.
PROiQ5ZKA2.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_02002. Ile_tRNA_synth_type1.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002301. Ile-tRNA-ligase.
IPR023585. Ile-tRNA-ligase_type1.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF9. PTHR11946:SF9. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
[Graphical view]
PRINTSiPR00984. TRNASYNTHILE.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00392. ileS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiSYIM_CHICK
AccessioniPrimary (citable) accession number: Q5ZKA2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2006
Last sequence update: November 22, 2004
Last modified: February 3, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.