Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alcohol dehydrogenase [NADP(+)]

Gene

AKR1A1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs (By similarity).By similarity

Catalytic activityi

An alcohol + NADP+ = an aldehyde + NADPH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei52Proton donorBy similarity1
Sitei82Lowers pKa of active site TyrBy similarity1
Binding sitei115SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi213 – 275NADPBy similarityAdd BLAST63

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase [NADP(+)] (EC:1.1.1.2)
Alternative name(s):
Aldehyde reductase
Aldo-keto reductase family 1 member A1
Gene namesi
Name:AKR1A1
ORF Names:RCJMB04_12g8
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003841511 – 327Alcohol dehydrogenase [NADP(+)]Add BLAST327

Proteomic databases

PaxDbiQ5ZK84.
PRIDEiQ5ZK84.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000032496.

Structurei

3D structure databases

ProteinModelPortaliQ5ZK84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

eggNOGiKOG1577. Eukaryota.
COG0656. LUCA.
HOGENOMiHOG000250272.
InParanoidiQ5ZK84.
KOiK00002.
PhylomeDBiQ5ZK84.

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 2 hits.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFiPIRSF000097. AKR. 1 hit.
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZK84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAGCDFVAL YNGQKIPLIG LGTWKSEPGQ VKEAVKYALS VGYRHVDCAA
60 70 80 90 100
AYSNEAEIGD AFQECVGPNK VIKREDLFVT SKLWNTKHHP EDVEPALRKT
110 120 130 140 150
LADLKLDYLD LYLMHWPHAF ERGDNLFPKN PDGTMRYDYT DYKDTWKAME
160 170 180 190 200
KLVEKGLAKA IGLSNFNSRQ IDDVLSVATV KPAVLQVECH PYLAQNELIA
210 220 230 240 250
HCQKRGLVVT AYSPLGSPDR MWKHPDEPVL LEEPGIKKLA EKYKKSPAQI
260 270 280 290 300
LLRWQAQRKV VTIPKSVTPA RILQNLQVFD FSLTEEEMSH VGSLNKNWRY
310 320
IVPMLTVNGK PVPRDAGHPN YPFNDPY
Length:327
Mass (Da):37,077
Last modified:November 23, 2004 - v1
Checksum:i8B590B4F560A855B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720200 mRNA. Translation: CAG31859.1.
RefSeqiNP_001006539.1. NM_001006539.2.
UniGeneiGga.22636.

Genome annotation databases

GeneIDi424599.
KEGGigga:424599.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720200 mRNA. Translation: CAG31859.1.
RefSeqiNP_001006539.1. NM_001006539.2.
UniGeneiGga.22636.

3D structure databases

ProteinModelPortaliQ5ZK84.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000032496.

Proteomic databases

PaxDbiQ5ZK84.
PRIDEiQ5ZK84.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi424599.
KEGGigga:424599.

Organism-specific databases

CTDi10327.

Phylogenomic databases

eggNOGiKOG1577. Eukaryota.
COG0656. LUCA.
HOGENOMiHOG000250272.
InParanoidiQ5ZK84.
KOiK00002.
PhylomeDBiQ5ZK84.

Miscellaneous databases

PROiQ5ZK84.

Family and domain databases

CDDicd06660. Aldo_ket_red. 1 hit.
Gene3Di3.20.20.100. 1 hit.
InterProiIPR001395. Aldo/ket_red/Kv-b.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]
PANTHERiPTHR11732. PTHR11732. 2 hits.
PfamiPF00248. Aldo_ket_red. 1 hit.
[Graphical view]
PIRSFiPIRSF000097. AKR. 1 hit.
PRINTSiPR00069. ALDKETRDTASE.
SUPFAMiSSF51430. SSF51430. 1 hit.
PROSITEiPS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAK1A1_CHICK
AccessioniPrimary (citable) accession number: Q5ZK84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: November 23, 2004
Last modified: October 5, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.