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Protein

Activated RNA polymerase II transcriptional coactivator p15

Gene

SUB1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Activated RNA polymerase II transcriptional coactivator p15
Alternative name(s):
SUB1 homolog
Gene namesi
Name:SUB1
Synonyms:RPO2TC1
ORF Names:RCJMB04_12p22
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome Z

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 126125Activated RNA polymerase II transcriptional coactivator p15PRO_0000291885Add
BLAST

Proteomic databases

PRIDEiQ5ZK63.

Expressioni

Gene expression databases

BgeeiENSGALG00000003248.

Structurei

3D structure databases

ProteinModelPortaliQ5ZK63.
SMRiQ5ZK63. Positions 62-126.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 5049RegulatoryBy similarityAdd
BLAST
Regioni76 – 10025Interaction with ssDNABy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 1916Ser-richAdd
BLAST
Compositional biasi23 – 5331Lys-richAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000008802.
HOGENOMiHOG000239157.
HOVERGENiHBG028243.
InParanoidiQ5ZK63.
OMAiQWNQLKD.
OrthoDBiEOG091G14VO.
PhylomeDBiQ5ZK63.

Family and domain databases

Gene3Di2.30.31.10. 1 hit.
InterProiIPR003173. PC4.
IPR009044. ssDNA-bd_transcriptional_reg.
[Graphical view]
PfamiPF02229. PC4. 1 hit.
[Graphical view]
SUPFAMiSSF54447. SSF54447. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ZK63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKSKELVSS SSSASDSDSE VDKKAKRKKQ AAPEKPVKKQ KTGESSKGAA
60 70 80 90 100
SSKQSSNRDE NMFQIGKMRY VSVRDFKGKV LIDIREYWMD QEGEMKPGRK
110 120
GISLNPEQWN QLKEQISDID DAVRKL
Length:126
Mass (Da):14,237
Last modified:November 23, 2004 - v1
Checksum:i13763AC004777739
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720221 mRNA. Translation: CAG31880.1.
RefSeqiNP_001008479.1. NM_001008479.1.
UniGeneiGga.11479.

Genome annotation databases

EnsembliENSGALT00000005135; ENSGALP00000005126; ENSGALG00000003248.
GeneIDi427425.
KEGGigga:427425.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720221 mRNA. Translation: CAG31880.1.
RefSeqiNP_001008479.1. NM_001008479.1.
UniGeneiGga.11479.

3D structure databases

ProteinModelPortaliQ5ZK63.
SMRiQ5ZK63. Positions 62-126.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5ZK63.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000005135; ENSGALP00000005126; ENSGALG00000003248.
GeneIDi427425.
KEGGigga:427425.

Organism-specific databases

CTDi10923.

Phylogenomic databases

GeneTreeiENSGT00390000008802.
HOGENOMiHOG000239157.
HOVERGENiHBG028243.
InParanoidiQ5ZK63.
OMAiQWNQLKD.
OrthoDBiEOG091G14VO.
PhylomeDBiQ5ZK63.

Miscellaneous databases

PROiQ5ZK63.

Gene expression databases

BgeeiENSGALG00000003248.

Family and domain databases

Gene3Di2.30.31.10. 1 hit.
InterProiIPR003173. PC4.
IPR009044. ssDNA-bd_transcriptional_reg.
[Graphical view]
PfamiPF02229. PC4. 1 hit.
[Graphical view]
SUPFAMiSSF54447. SSF54447. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTCP4_CHICK
AccessioniPrimary (citable) accession number: Q5ZK63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: November 23, 2004
Last modified: September 7, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.