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Protein

Toll-interacting protein

Gene

TOLLIP

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAutophagy, Immunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-interacting protein
Gene namesi
Name:TOLLIP
ORF Names:RCJMB04_14a3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003849321 – 274Toll-interacting proteinAdd BLAST274

Proteomic databases

PaxDbiQ5ZK05

Interactioni

Subunit structurei

Interacts with ATG8 family proteins (via AIM motifs), and ubiquitin (via CUE domain).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000010809

Structurei

3D structure databases

ProteinModelPortaliQ5ZK05
SMRiQ5ZK05
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 135C2Add BLAST96
Domaini229 – 272CUEPROSITE-ProRule annotationAdd BLAST44

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi133 – 136AIM14
Motifi151 – 154AIM24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi28 – 34Poly-Gln7

Domaini

Both ATG8-interaction motifs (AIM1 and AIM2) are required for the association with ATG8 family proteins.By similarity

Sequence similaritiesi

Belongs to the tollip family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IE45 Eukaryota
ENOG410XQPY LUCA
HOGENOMiHOG000293427
InParanoidiQ5ZK05
KOiK05402
PhylomeDBiQ5ZK05

Family and domain databases

CDDicd04016 C2_Tollip, 1 hit
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR003892 CUE
IPR037301 Tollip_C2
IPR009060 UBA-like_sf
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF02845 CUE, 1 hit
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00546 CUE, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
PROSITEiView protein in PROSITE
PS51140 CUE, 1 hit

Sequencei

Sequence statusi: Complete.

Q5ZK05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTVSTQRG PVYVGELPQD FLRITPTQQQ QQIQLDAQAA QQLQYGGPMS
60 70 80 90 100
TVGRLSITVV QAKLAKNYGM TRMDPYCRIR LGYAVYETPT AHNGAKNPRW
110 120 130 140 150
NKVIQCTVPP GVDSFYLEIF DERAFSMDDR IAWTHITIPE SLKQGNVEDE
160 170 180 190 200
WYSLSGRQGD DKEGMINLVM SYTSLPAAMM MQPQPVVLMP TVYQQGVGYV
210 220 230 240 250
PIAGMPAVCN PDMVPVAIPP PAVNPQHLCN EEDLKSIQDM FPNMDREVIR
260 270
SVLEAQRGNK NAAINSLLQM TEES
Length:274
Mass (Da):30,540
Last modified:November 23, 2004 - v1
Checksum:iA4618E78F5BB6469
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720279 mRNA Translation: CAG31938.1
RefSeqiNP_001006471.1, NM_001006471.1
UniGeneiGga.42665

Genome annotation databases

GeneIDi423099
KEGGigga:423099

Similar proteinsi

Entry informationi

Entry nameiTOLIP_CHICK
AccessioniPrimary (citable) accession number: Q5ZK05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: November 23, 2004
Last modified: March 28, 2018
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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