Reviewed, UniProtKB/Swiss-Prot Q5ZJZ5 (BDH_CHICK)

Names and origin

Protein names

Recommended name:
    D-beta-hydroxybutyrate dehydrogenase, mitochondrial
      Short name=BDH
    EC=1.1.1.30
Alternative name(s):
    3-hydroxybutyrate dehydrogenase

Gene names

Name:	BDH1
Synonyms:	BDH
ORF Names:	RCJMB04_14d17

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	(R)-3-hydroxybutanoate + NAD+ = acetoacetate + NADH.
Enzyme regulation	Requires phosphatidylcholine as an allosteric activator for enzymatic activity By similarity.
Subunit structure	Homotetramer By similarity.
Subcellular location	Mitochondrion matrix By similarity.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Allosteric enzyme
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-hydroxybutyrate dehydrogenase activity Inferred from electronic annotation. Source: EC binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 46	46	Mitochondrion By similarity
	Chain	47 – 339	293	D-beta-hydroxybutyrate dehydrogenase, mitochondrial		PRO_0000031963
Sites
	Active site	204	1	Proton acceptor By similarity
	Binding site	191	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5ZJZ5-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 208BADB539C6F108	FASTA	339	38,237
	10 20 30 40 50 60 MLATKLSRPL LNLPVKTLTV KNPGNSFRPV QRFCFPLLSS CGSRSYASEV DQIGSRAVLT 70 80 90 100 110 120 LGLDLPWPKH LHTKGFIIYA GCLQKNKGEG GSKDLDNMNS DRMRTVQLNV CDSKEVDRAV 130 140 150 160 170 180 EHVNSSLEDP EKGLWGLVNN AGISTFGEVE FTSMDTYMEV AEVNLWGTVR TTKAFLPLIR 190 200 210 220 230 240 RSKGRVVNIS SMMGRMGSPA RSPYCITKFG VEAFSDCLRY EMQPQGVMVS IVEPGNFIAV 250 260 270 280 290 300 TNLYSPERIK AIADKMWDEL PEIVRKDYGR KYFDEQVSKM ETYCNSGSTD TSPVIESVAH 310 320 330 ALTSTAPYTR YHPMDYYWWL RMQIMTHMPA AISDRLYVY

References

[1]

"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis." Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M. Genome Biol. 6:RESEARCH006.1-RESEARCH006.9(2005) [PubMed: 15642098] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: CB. Tissue: Bursa of Fabricius.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ720289 mRNA. Translation: CAG31948.1.
IPI	IPI00594102.
RefSeq	NP_001006547.1.
UniGene	Gga.5444
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5ZJZ5.
Genome annotation databases
Ensembl	ENSGALT00000011255; ENSGALP00000011241; ENSGALG00000006947; Gallus gallus. [Genome view]
GeneID	424891.
KEGG	gga:424891.
Organism-specific databases
CTD	424891.
Phylogenomic databases
HOGENOM	Q5ZJZ5.
HOVERGEN	Q5ZJZ5.
Enzyme and pathway databases
BRENDA	1.1.1.30. 4.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BDH_CHICK

Accession

Primary (citable) accession number: Q5ZJZ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2005
Last sequence update:	November 23, 2004
Last modified:	September 1, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)