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Protein

Vesicle-trafficking protein SEC22b

Gene

SEC22B

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-GGA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-GGA-5694530. Cargo concentration in the ER.

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicle-trafficking protein SEC22b
Alternative name(s):
SEC22 vesicle-trafficking protein homolog B
Gene namesi
Name:SEC22BBy similarity
ORF Names:RCJMB04_15c3
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 8

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 194194CytoplasmicSequence analysisAdd
BLAST
Transmembranei195 – 21521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 215215Vesicle-trafficking protein SEC22bPRO_0000252242Add
BLAST

Proteomic databases

PaxDbiQ5ZJW4.
PRIDEiQ5ZJW4.

Interactioni

Subunit structurei

Component of 2 distinct SNARE complexes.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000004591.

Structurei

3D structure databases

ProteinModelPortaliQ5ZJW4.
SMRiQ5ZJW4. Positions 1-157.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 119114LonginPROSITE-ProRule annotationAdd
BLAST
Domaini134 – 19461v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the synaptobrevin family.Sequence analysis
Contains 1 longin domain.PROSITE-ProRule annotation
Contains 1 v-SNARE coiled-coil homology domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0862. Eukaryota.
COG5143. LUCA.
GeneTreeiENSGT00510000046833.
HOGENOMiHOG000044957.
HOVERGENiHBG052748.
InParanoidiQ5ZJW4.
KOiK08517.
OMAiVLYFWVL.
PhylomeDBiQ5ZJW4.

Family and domain databases

Gene3Di1.10.3840.10. 1 hit.
3.30.450.50. 1 hit.
InterProiIPR011012. Longin-like_dom.
IPR010908. Longin_dom.
IPR001388. Synaptobrevin.
[Graphical view]
PfamiPF13774. Longin. 1 hit.
PF00957. Synaptobrevin. 1 hit.
[Graphical view]
PRINTSiPR00219. SYNAPTOBREVN.
SMARTiSM01270. Longin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS50859. LONGIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZJW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLLTMIARV ADGLPLAASM QEDEQSGRDL QQYQSQAKQL FRKLNEQSPT
60 70 80 90 100
RCTLEAGAMA FHYIIEKGVC YLVLCEAAFP KKLAFAYLED LQSEFDEQHG
110 120 130 140 150
KKVPTVSRPY SFIEFDTYIQ KTKKLYIDSR ARRNLGSINT ELQDVQRIMV
160 170 180 190 200
ANIEEVLQRG EALSALDSKA NNLSSLSKKY RQDAKYLNMR STYAKLAAVA
210
VFFIMLIVYV RFWWL
Length:215
Mass (Da):24,718
Last modified:November 23, 2004 - v1
Checksum:iB0ADF3A7CF16C870
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720320 mRNA. Translation: CAG31979.1.
RefSeqiNP_001026437.1. NM_001031266.3.
UniGeneiGga.1782.

Genome annotation databases

EnsembliENSGALT00000045229; ENSGALP00000041744; ENSGALG00000026268.
GeneIDi424377.
KEGGigga:424377.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720320 mRNA. Translation: CAG31979.1.
RefSeqiNP_001026437.1. NM_001031266.3.
UniGeneiGga.1782.

3D structure databases

ProteinModelPortaliQ5ZJW4.
SMRiQ5ZJW4. Positions 1-157.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000004591.

Proteomic databases

PaxDbiQ5ZJW4.
PRIDEiQ5ZJW4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000045229; ENSGALP00000041744; ENSGALG00000026268.
GeneIDi424377.
KEGGigga:424377.

Organism-specific databases

CTDi9554.

Phylogenomic databases

eggNOGiKOG0862. Eukaryota.
COG5143. LUCA.
GeneTreeiENSGT00510000046833.
HOGENOMiHOG000044957.
HOVERGENiHBG052748.
InParanoidiQ5ZJW4.
KOiK08517.
OMAiVLYFWVL.
PhylomeDBiQ5ZJW4.

Enzyme and pathway databases

ReactomeiR-GGA-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-GGA-5694530. Cargo concentration in the ER.

Miscellaneous databases

NextBioi20826715.
PROiQ5ZJW4.

Family and domain databases

Gene3Di1.10.3840.10. 1 hit.
3.30.450.50. 1 hit.
InterProiIPR011012. Longin-like_dom.
IPR010908. Longin_dom.
IPR001388. Synaptobrevin.
[Graphical view]
PfamiPF13774. Longin. 1 hit.
PF00957. Synaptobrevin. 1 hit.
[Graphical view]
PRINTSiPR00219. SYNAPTOBREVN.
SMARTiSM01270. Longin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS50859. LONGIN. 1 hit.
PS50892. V_SNARE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CBImported.
    Tissue: Bursa of FabriciusImported.

Entry informationi

Entry nameiSC22B_CHICK
AccessioniPrimary (citable) accession number: Q5ZJW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: November 23, 2004
Last modified: May 11, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.