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Reviewed, UniProtKB/Swiss-Prot Q5ZJU3 (ASNS_CHICK)

Last modified February 9, 2010. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Asparagine synthetase [glutamine-hydrolyzing]
    EC=6.3.5.4
Alternative name(s):
    Glutamine-dependent asparagine synthetase
Gene names
Name: ASNS
ORF Names: RCJMB04_15l3
OrganismGallus gallus (Chicken)
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length561 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Catalytic activity

ATP + L-aspartate + L-glutamine + H2O = AMP + diphosphate + L-asparagine + L-glutamate.

Pathway

Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1.

Sequence similarities

Contains 1 asparagine synthetase domain.

Contains 1 glutamine amidotransferase type-2 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 561560Asparagine synthetase [glutamine-hydrolyzing]
PRO_0000056915

Regions

Domain2 – 191190Glutamine amidotransferase type-2
Domain213 – 536324Asparagine synthetase

Sites

Active site21For GATase activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5ZJU3-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 94EFE934BED58FBF

FASTA56164,097
        10         20         30         40         50         60 
MCGIWALFGS DECLSVQCLS AMKIAHRGPD AFRFENVNGF TNCCFGFHRL AVVDQLYGMQ 

        70         80         90        100        110        120 
PIRVKKFPYL WLCYNGEIYN FKQLQEQFGF EYQTLVDGEV ILHLYNRGGI EQTASMLDGV 

       130        140        150        160        170        180 
FAFILLDTAN RKVFLARDTY GVRPLFKVLT DDGFLGVCSE AKGLINLKHS TSLFPKVEPF 

       190        200        210        220        230        240 
LPGHYEVLDL KPSGKVVSVE VVKFHSYKDE PLHAACDTVG NLPSGFDLET VKSNIRVLFE 

       250        260        270        280        290        300 
NAVRKRLMAH RRIGCLLSGG LDSSLVAAVL LKLMKEMNIK YPLQTFAIGM ENSPDLLAAR 

       310        320        330        340        350        360 
KVAAHIGSEH HEVIFNSEEG IQAVEEVIFS LETYDITTVR ASIGMYLVSK YIRKKTDSVV 

       370        380        390        400        410        420 
IFSGEGSDEL TQGYIYFHKA PSPEEAAEES ERLLKELYLF DVLRADRTTA AHGLELRVPF 

       430        440        450        460        470        480 
LDHRFTSYYL SLPAELRIPK NGIEKYLLRQ SFEDSNLLPK EILWRPKEAF SDGIASVKKS 

       490        500        510        520        530        540 
WFSILQDYID QQVDDLLLEK AAEKYPFNPP RTKESYYYRQ IFEKHYPGRS SWLPHYWMPR 

       550        560 
WVEATDPSAR TLKHYKSAIQ E 

« Hide

References

[1]"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis."
Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.
Genome Biol. 6:R6.1-R6.9(2005) [PubMed: 15642098] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: CB.
Tissue: Bursa of Fabricius.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ720341 mRNA. Translation: CAG32000.1.
IPIIPI00575723.
RefSeqNP_001026148.1.
UniGeneGga.22299

3D structure databases

SMRQ5ZJU3. Positions 1-532.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5ZJU3.

Genome annotation databases

EnsemblENSGALT00000015862; ENSGALP00000015846; ENSGALG00000009748; Gallus gallus. [Genome view]
GeneID420574.
KEGGgga:420574.

Organism-specific databases

CTD420574.

Phylogenomic databases

eggNOGveNOG04885.
HOGENOMHBG752912.
HOVERGENQ5ZJU3.
InParanoidQ5ZJU3.
PhylomeDBQ5ZJU3.

Enzyme and pathway databases

BRENDA6.3.5.4. 4.

Family and domain databases

InterProIPR006426. Asn_synth_AEB.
IPR001962. Asn_synthase.
IPR000583. GATase_2.
IPR017932. GATase_II.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
Gene3DG3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
PfamPF00733. Asn_synthase. 1 hit.
PF00310. GATase_2. 1 hit.
[Graphical view]
TIGRFAMsTIGR01536. asn_synth_AEB. 1 hit.
PROSITEPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASNS_CHICK
AccessionPrimary (citable) accession number: Q5ZJU3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: January 23, 2007
Last modified: February 9, 2010
This is version 39 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents