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Protein

Elongation of very long chain fatty acids protein 6

Gene

ELOVL6

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.UniRule annotation

Catalytic activityi

A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO2.UniRule annotation

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-GGA-2426168. Activation of gene expression by SREBF (SREBP).
R-GGA-75876. Synthesis of very long-chain fatty acyl-CoAs.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation of very long chain fatty acids protein 6UniRule annotationCurated (EC:2.3.1.199UniRule annotationBy similarity)
Alternative name(s):
3-keto acyl-CoA synthase ELOVL6UniRule annotation
ELOVL fatty acid elongase 6UniRule annotation
Short name:
ELOVL FA elongase 6UniRule annotation
Very long chain 3-ketoacyl-CoA synthase 6UniRule annotation
Very long chain 3-oxoacyl-CoA synthase 6UniRule annotation
Gene namesi
Name:ELOVL6UniRule annotation
ORF Names:RCJMB04_16d24
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Endoplasmic reticulum membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei34 – 5118HelicalUniRule annotationAdd
BLAST
Transmembranei70 – 9021HelicalUniRule annotationAdd
BLAST
Transmembranei111 – 13121HelicalUniRule annotationAdd
BLAST
Transmembranei137 – 15620HelicalUniRule annotationAdd
BLAST
Transmembranei159 – 17921HelicalUniRule annotationAdd
BLAST
Transmembranei197 – 21721HelicalUniRule annotationAdd
BLAST
Transmembranei232 – 25221HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Elongation of very long chain fatty acids protein 6PRO_0000282849Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)UniRule annotation

Post-translational modificationi

N-Glycosylated.UniRule annotation

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5ZJR8.

Expressioni

Gene expression databases

BgeeiENSGALG00000012131.
ExpressionAtlasiQ5ZJR8. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000019792.

Family & Domainsi

Sequence similaritiesi

Belongs to the ELO family. ELOVL6 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3072. Eukaryota.
ENOG410Z3FZ. LUCA.
HOGENOMiHOG000038943.
HOVERGENiHBG099423.
InParanoidiQ5ZJR8.
KOiK10203.
PhylomeDBiQ5ZJR8.

Family and domain databases

HAMAPiMF_03206. VLCF_elongase_6. 1 hit.
InterProiIPR030457. ELO_CS.
IPR002076. ELO_fam.
IPR033675. ELOVL6.
[Graphical view]
PANTHERiPTHR11157. PTHR11157. 1 hit.
PTHR11157:SF42. PTHR11157:SF42. 1 hit.
PfamiPF01151. ELO. 1 hit.
[Graphical view]
PROSITEiPS01188. ELO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZJR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNMSVLTLQE YEFEKQFNEH EAIQWMQENW KKSFLFSALY AAFIFGGRHL
60 70 80 90 100
MNKRAKFELR KPLVLWSLSL AVFSIFGAVR TAPYMLYILM TKGLKQSVCD
110 120 130 140 150
QSFYIGPVSK FWAYAFVLSK APELGDTIFI ILRKQKLIFL HWYHHITVLL
160 170 180 190 200
YSWYSYKDMV AGGGWFMTMN YGVHAVMYSY YALRAAGFRV SRKFAMFITL
210 220 230 240 250
SQITQMLVGC VINYLVFSWM QHGQCHSHVQ NIIWSSLMYL SYFVLFCHFF
260
FEAYIGKTTK ARKVD
Length:265
Mass (Da):31,268
Last modified:November 23, 2004 - v1
Checksum:i15991AFE36ECE305
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720366 mRNA. Translation: CAG32025.1.
RefSeqiNP_001026710.1. NM_001031539.1.
UniGeneiGga.7376.

Genome annotation databases

GeneIDi428772.
KEGGigga:428772.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720366 mRNA. Translation: CAG32025.1.
RefSeqiNP_001026710.1. NM_001031539.1.
UniGeneiGga.7376.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000019792.

Proteomic databases

PaxDbiQ5ZJR8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi428772.
KEGGigga:428772.

Organism-specific databases

CTDi79071.

Phylogenomic databases

eggNOGiKOG3072. Eukaryota.
ENOG410Z3FZ. LUCA.
HOGENOMiHOG000038943.
HOVERGENiHBG099423.
InParanoidiQ5ZJR8.
KOiK10203.
PhylomeDBiQ5ZJR8.

Enzyme and pathway databases

UniPathwayiUPA00094.
ReactomeiR-GGA-2426168. Activation of gene expression by SREBF (SREBP).
R-GGA-75876. Synthesis of very long-chain fatty acyl-CoAs.

Miscellaneous databases

PROiQ5ZJR8.

Gene expression databases

BgeeiENSGALG00000012131.
ExpressionAtlasiQ5ZJR8. baseline.

Family and domain databases

HAMAPiMF_03206. VLCF_elongase_6. 1 hit.
InterProiIPR030457. ELO_CS.
IPR002076. ELO_fam.
IPR033675. ELOVL6.
[Graphical view]
PANTHERiPTHR11157. PTHR11157. 1 hit.
PTHR11157:SF42. PTHR11157:SF42. 1 hit.
PfamiPF01151. ELO. 1 hit.
[Graphical view]
PROSITEiPS01188. ELO. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiELOV6_CHICK
AccessioniPrimary (citable) accession number: Q5ZJR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: November 23, 2004
Last modified: September 7, 2016
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.