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Q5ZJN4

- UBP10_CHICK

UniProt

Q5ZJN4 - UBP10_CHICK

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Protein

Ubiquitin carboxyl-terminal hydrolase 10

Gene

USP10

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteracts MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei410 – 4101NucleophilePROSITE-ProRule annotation
Active sitei736 – 7361Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: UniProtKB
  2. ion channel binding Source: UniProtKB
  3. p53 binding Source: UniProtKB
  4. ubiquitin-specific protease activity Source: UniProtKB
  5. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. autophagy Source: UniProtKB-KW
  2. DNA damage response, signal transduction by p53 class mediator Source: UniProtKB
  3. DNA repair Source: UniProtKB-KW
  4. protein deubiquitination Source: UniProtKB
  5. regulation of autophagy Source: UniProtKB
  6. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Autophagy, DNA damage, DNA repair, Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.018.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 10 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 10
Ubiquitin thioesterase 10
Ubiquitin-specific-processing protease 10
Gene namesi
Name:USP10
ORF Names:RCJMB04_16o18
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. early endosome Source: UniProtKB
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 785785Ubiquitin carboxyl-terminal hydrolase 10PRO_0000393001Add
BLAST

Proteomic databases

PaxDbiQ5ZJN4.

Interactioni

Protein-protein interaction databases

BioGridi677409. 1 interaction.
STRINGi9031.ENSGALP00000038252.

Structurei

3D structure databases

ProteinModelPortaliQ5ZJN4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini401 – 782382USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family. USP10 subfamily.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiCOG5533.
HOGENOMiHOG000285959.
HOVERGENiHBG059823.
InParanoidiQ5ZJN4.
KOiK11841.
PhylomeDBiQ5ZJN4.

Family and domain databases

InterProiIPR009818. Ataxin-2_C.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR028767. USP10.
[Graphical view]
PANTHERiPTHR24006:SF69. PTHR24006:SF69. 1 hit.
PfamiPF07145. PAM2. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZJN4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVNGAQYIF GEFSPDEFNQ FFVTPRCSVE LPPYNETVSC GIKSTNEEYQ
60 70 80 90 100
RIEFGVNEVI ETESSVLNNT DYSISSTLNP QAPEFILSCA PAQKTPDETN
110 120 130 140 150
YNSIDCQFSD PTLTLDSGSN AENDGLSGGL GQRERKKKKK RPPGYYSYLE
160 170 180 190 200
DVSDGVAPTE ALVNGHANSS GLNSIGTEDT ELTGDIPSLA TPRTCNSPDN
210 220 230 240 250
SVDFVHEAVS DDSVSSALDN TRTAGQPEVC RVTNSEQFCI PSETGRDSPL
260 270 280 290 300
RTAVVQPYAG TDTTESLGVT NGQTLESSGE DTAANGVELH TVESTDSDQA
310 320 330 340 350
KPEEASPTTE ATATVAGSVP VNQPAKSWAS LFHNSKPSAS TSVVYVETKY
360 370 380 390 400
TPPATSTLVP EKQVEVKEGP VPVSEDPVAI KIAELLENVK LVHKPVSLQP
410 420 430 440 450
RGLINKGNWC YINATLQALV ACPPMYHLMK SIPMYSKSQR PCTSTPMIDS
460 470 480 490 500
FVRLMNEFTN MPVPPKAKQA LGDKIVRDIR PGAAFEPTYI YRLLTVIKSS
510 520 530 540 550
LSEKGRQEDA EEYLGFILNG LHEEMLTLKK LLSPHNEKLS VSNGPEVQTV
560 570 580 590 600
REEEEQDEQG EGSEDEWEQV GPRNKSSVTR QADFVQTPIT DIFGGHIRSV
610 620 630 640 650
VYQQSSKESA TLQPFFTLQL DIQSDKIRTV QDALESLVAR ESVQGYTTKT
660 670 680 690 700
KQEVEISRRV TLEELPPVLV LHLKRFVYEK TGGCQKLIKN IEYPVDLEIS
710 720 730 740 750
KELLSPGVKS KIFKGQRTYR LFAVVYHHGN SATGDHYTTD VFQIGLNGWL
760 770 780
RIDDQAVKVI NQYQVVKPSA ERTAYLLYYR RVDLL
Length:785
Mass (Da):86,556
Last modified:November 23, 2004 - v1
Checksum:i97AB9EAE92AE32AB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720400 mRNA. Translation: CAG32059.1.
RefSeqiNP_001006130.1. NM_001006130.1.
UniGeneiGga.3193.

Genome annotation databases

GeneIDi415817.
KEGGigga:415817.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720400 mRNA. Translation: CAG32059.1 .
RefSeqi NP_001006130.1. NM_001006130.1.
UniGenei Gga.3193.

3D structure databases

ProteinModelPortali Q5ZJN4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 677409. 1 interaction.
STRINGi 9031.ENSGALP00000038252.

Protein family/group databases

MEROPSi C19.018.

Proteomic databases

PaxDbi Q5ZJN4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 415817.
KEGGi gga:415817.

Organism-specific databases

CTDi 9100.

Phylogenomic databases

eggNOGi COG5533.
HOGENOMi HOG000285959.
HOVERGENi HBG059823.
InParanoidi Q5ZJN4.
KOi K11841.
PhylomeDBi Q5ZJN4.

Miscellaneous databases

NextBioi 20819362.
PROi Q5ZJN4.

Family and domain databases

InterProi IPR009818. Ataxin-2_C.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR028767. USP10.
[Graphical view ]
PANTHERi PTHR24006:SF69. PTHR24006:SF69. 1 hit.
Pfami PF07145. PAM2. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiUBP10_CHICK
AccessioniPrimary (citable) accession number: Q5ZJN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: November 23, 2004
Last modified: November 26, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3