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Q5ZJN4

- UBP10_CHICK

UniProt

Q5ZJN4 - UBP10_CHICK

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Protein

Ubiquitin carboxyl-terminal hydrolase 10

Gene
USP10, RCJMB04_16o18
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteracts MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei410 – 4101Nucleophile By similarity
Active sitei736 – 7361Proton acceptor By similarity

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: UniProtKB
  2. ion channel binding Source: UniProtKB
  3. p53 binding Source: UniProtKB
  4. ubiquitin-specific protease activity Source: UniProtKB
  5. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. autophagy Source: UniProtKB-KW
  2. DNA damage response, signal transduction by p53 class mediator Source: UniProtKB
  3. DNA repair Source: UniProtKB-KW
  4. protein deubiquitination Source: UniProtKB
  5. regulation of autophagy Source: UniProtKB
  6. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Autophagy, DNA damage, DNA repair, Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.018.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 10 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 10
Ubiquitin thioesterase 10
Ubiquitin-specific-processing protease 10
Gene namesi
Name:USP10
ORF Names:RCJMB04_16o18
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. early endosome Source: UniProtKB
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 785785Ubiquitin carboxyl-terminal hydrolase 10PRO_0000393001Add
BLAST

Proteomic databases

PaxDbiQ5ZJN4.

Interactioni

Protein-protein interaction databases

BioGridi677409. 1 interaction.
STRINGi9031.ENSGALP00000038252.

Structurei

3D structure databases

ProteinModelPortaliQ5ZJN4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini401 – 782382USPAdd
BLAST

Sequence similaritiesi

Contains 1 USP domain.

Phylogenomic databases

eggNOGiCOG5533.
HOGENOMiHOG000285959.
HOVERGENiHBG059823.
InParanoidiQ5ZJN4.
KOiK11841.
PhylomeDBiQ5ZJN4.

Family and domain databases

InterProiIPR009818. Ataxin-2_C.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR028767. USP10.
[Graphical view]
PANTHERiPTHR24006:SF69. PTHR24006:SF69. 1 hit.
PfamiPF07145. PAM2. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZJN4-1 [UniParc]FASTAAdd to Basket

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MAVNGAQYIF GEFSPDEFNQ FFVTPRCSVE LPPYNETVSC GIKSTNEEYQ    50
RIEFGVNEVI ETESSVLNNT DYSISSTLNP QAPEFILSCA PAQKTPDETN 100
YNSIDCQFSD PTLTLDSGSN AENDGLSGGL GQRERKKKKK RPPGYYSYLE 150
DVSDGVAPTE ALVNGHANSS GLNSIGTEDT ELTGDIPSLA TPRTCNSPDN 200
SVDFVHEAVS DDSVSSALDN TRTAGQPEVC RVTNSEQFCI PSETGRDSPL 250
RTAVVQPYAG TDTTESLGVT NGQTLESSGE DTAANGVELH TVESTDSDQA 300
KPEEASPTTE ATATVAGSVP VNQPAKSWAS LFHNSKPSAS TSVVYVETKY 350
TPPATSTLVP EKQVEVKEGP VPVSEDPVAI KIAELLENVK LVHKPVSLQP 400
RGLINKGNWC YINATLQALV ACPPMYHLMK SIPMYSKSQR PCTSTPMIDS 450
FVRLMNEFTN MPVPPKAKQA LGDKIVRDIR PGAAFEPTYI YRLLTVIKSS 500
LSEKGRQEDA EEYLGFILNG LHEEMLTLKK LLSPHNEKLS VSNGPEVQTV 550
REEEEQDEQG EGSEDEWEQV GPRNKSSVTR QADFVQTPIT DIFGGHIRSV 600
VYQQSSKESA TLQPFFTLQL DIQSDKIRTV QDALESLVAR ESVQGYTTKT 650
KQEVEISRRV TLEELPPVLV LHLKRFVYEK TGGCQKLIKN IEYPVDLEIS 700
KELLSPGVKS KIFKGQRTYR LFAVVYHHGN SATGDHYTTD VFQIGLNGWL 750
RIDDQAVKVI NQYQVVKPSA ERTAYLLYYR RVDLL 785
Length:785
Mass (Da):86,556
Last modified:November 23, 2004 - v1
Checksum:i97AB9EAE92AE32AB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ720400 mRNA. Translation: CAG32059.1.
RefSeqiNP_001006130.1. NM_001006130.1.
UniGeneiGga.3193.

Genome annotation databases

GeneIDi415817.
KEGGigga:415817.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ720400 mRNA. Translation: CAG32059.1 .
RefSeqi NP_001006130.1. NM_001006130.1.
UniGenei Gga.3193.

3D structure databases

ProteinModelPortali Q5ZJN4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 677409. 1 interaction.
STRINGi 9031.ENSGALP00000038252.

Protein family/group databases

MEROPSi C19.018.

Proteomic databases

PaxDbi Q5ZJN4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 415817.
KEGGi gga:415817.

Organism-specific databases

CTDi 9100.

Phylogenomic databases

eggNOGi COG5533.
HOGENOMi HOG000285959.
HOVERGENi HBG059823.
InParanoidi Q5ZJN4.
KOi K11841.
PhylomeDBi Q5ZJN4.

Miscellaneous databases

NextBioi 20819362.
PROi Q5ZJN4.

Family and domain databases

InterProi IPR009818. Ataxin-2_C.
IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR028767. USP10.
[Graphical view ]
PANTHERi PTHR24006:SF69. PTHR24006:SF69. 1 hit.
Pfami PF07145. PAM2. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiUBP10_CHICK
AccessioniPrimary (citable) accession number: Q5ZJN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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