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Q5ZJN4

- UBP10_CHICK

UniProt

Q5ZJN4 - UBP10_CHICK

Protein

Ubiquitin carboxyl-terminal hydrolase 10

Gene

USP10

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteracts MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei410 – 4101NucleophilePROSITE-ProRule annotation
    Active sitei736 – 7361Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: UniProtKB
    2. ion channel binding Source: UniProtKB
    3. p53 binding Source: UniProtKB
    4. ubiquitin-specific protease activity Source: UniProtKB
    5. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. autophagy Source: UniProtKB-KW
    2. DNA damage response, signal transduction by p53 class mediator Source: UniProtKB
    3. DNA repair Source: UniProtKB-KW
    4. protein deubiquitination Source: UniProtKB
    5. regulation of autophagy Source: UniProtKB
    6. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Autophagy, DNA damage, DNA repair, Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.018.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 10 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 10
    Ubiquitin thioesterase 10
    Ubiquitin-specific-processing protease 10
    Gene namesi
    Name:USP10
    ORF Names:RCJMB04_16o18
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. early endosome Source: UniProtKB
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 785785Ubiquitin carboxyl-terminal hydrolase 10PRO_0000393001Add
    BLAST

    Proteomic databases

    PaxDbiQ5ZJN4.

    Interactioni

    Protein-protein interaction databases

    BioGridi677409. 1 interaction.
    STRINGi9031.ENSGALP00000038252.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5ZJN4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini401 – 782382USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family. USP10 subfamily.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5533.
    HOGENOMiHOG000285959.
    HOVERGENiHBG059823.
    InParanoidiQ5ZJN4.
    KOiK11841.
    PhylomeDBiQ5ZJN4.

    Family and domain databases

    InterProiIPR009818. Ataxin-2_C.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    IPR028767. USP10.
    [Graphical view]
    PANTHERiPTHR24006:SF69. PTHR24006:SF69. 1 hit.
    PfamiPF07145. PAM2. 1 hit.
    PF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5ZJN4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAVNGAQYIF GEFSPDEFNQ FFVTPRCSVE LPPYNETVSC GIKSTNEEYQ    50
    RIEFGVNEVI ETESSVLNNT DYSISSTLNP QAPEFILSCA PAQKTPDETN 100
    YNSIDCQFSD PTLTLDSGSN AENDGLSGGL GQRERKKKKK RPPGYYSYLE 150
    DVSDGVAPTE ALVNGHANSS GLNSIGTEDT ELTGDIPSLA TPRTCNSPDN 200
    SVDFVHEAVS DDSVSSALDN TRTAGQPEVC RVTNSEQFCI PSETGRDSPL 250
    RTAVVQPYAG TDTTESLGVT NGQTLESSGE DTAANGVELH TVESTDSDQA 300
    KPEEASPTTE ATATVAGSVP VNQPAKSWAS LFHNSKPSAS TSVVYVETKY 350
    TPPATSTLVP EKQVEVKEGP VPVSEDPVAI KIAELLENVK LVHKPVSLQP 400
    RGLINKGNWC YINATLQALV ACPPMYHLMK SIPMYSKSQR PCTSTPMIDS 450
    FVRLMNEFTN MPVPPKAKQA LGDKIVRDIR PGAAFEPTYI YRLLTVIKSS 500
    LSEKGRQEDA EEYLGFILNG LHEEMLTLKK LLSPHNEKLS VSNGPEVQTV 550
    REEEEQDEQG EGSEDEWEQV GPRNKSSVTR QADFVQTPIT DIFGGHIRSV 600
    VYQQSSKESA TLQPFFTLQL DIQSDKIRTV QDALESLVAR ESVQGYTTKT 650
    KQEVEISRRV TLEELPPVLV LHLKRFVYEK TGGCQKLIKN IEYPVDLEIS 700
    KELLSPGVKS KIFKGQRTYR LFAVVYHHGN SATGDHYTTD VFQIGLNGWL 750
    RIDDQAVKVI NQYQVVKPSA ERTAYLLYYR RVDLL 785
    Length:785
    Mass (Da):86,556
    Last modified:November 23, 2004 - v1
    Checksum:i97AB9EAE92AE32AB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ720400 mRNA. Translation: CAG32059.1.
    RefSeqiNP_001006130.1. NM_001006130.1.
    UniGeneiGga.3193.

    Genome annotation databases

    GeneIDi415817.
    KEGGigga:415817.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ720400 mRNA. Translation: CAG32059.1 .
    RefSeqi NP_001006130.1. NM_001006130.1.
    UniGenei Gga.3193.

    3D structure databases

    ProteinModelPortali Q5ZJN4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 677409. 1 interaction.
    STRINGi 9031.ENSGALP00000038252.

    Protein family/group databases

    MEROPSi C19.018.

    Proteomic databases

    PaxDbi Q5ZJN4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 415817.
    KEGGi gga:415817.

    Organism-specific databases

    CTDi 9100.

    Phylogenomic databases

    eggNOGi COG5533.
    HOGENOMi HOG000285959.
    HOVERGENi HBG059823.
    InParanoidi Q5ZJN4.
    KOi K11841.
    PhylomeDBi Q5ZJN4.

    Miscellaneous databases

    NextBioi 20819362.
    PROi Q5ZJN4.

    Family and domain databases

    InterProi IPR009818. Ataxin-2_C.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    IPR028767. USP10.
    [Graphical view ]
    PANTHERi PTHR24006:SF69. PTHR24006:SF69. 1 hit.
    Pfami PF07145. PAM2. 1 hit.
    PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: CB.
      Tissue: Bursa of Fabricius.

    Entry informationi

    Entry nameiUBP10_CHICK
    AccessioniPrimary (citable) accession number: Q5ZJN4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 23, 2010
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3