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Protein

Ras-related protein Rab-11A

Gene

RAB11A

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi18 – 269GTPBy similarity
Nucleotide bindingi66 – 705GTPBy similarity
Nucleotide bindingi124 – 1274GTPBy similarity
Nucleotide bindingi154 – 1563GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-GGA-5620912. Anchoring of the basal body to the plasma membrane.
R-GGA-5620916. VxPx cargo-targeting to cilium.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-11A
Gene namesi
Name:RAB11A
ORF Names:RCJMB04_16p4
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 10

Subcellular locationi

  • Cell membrane By similarity; Lipid-anchor Curated
  • Recycling endosome membrane By similarity; Lipid-anchor Curated
  • Cleavage furrow By similarity
  • Cytoplasmic vesiclephagosome By similarity

  • Note: Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Localizes to the cleavage furrow. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis. Recruited to phagosomes containing S.aureus or M.tuberculosis.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 213212Ras-related protein Rab-11APRO_0000121157Add
BLAST
Propeptidei214 – 2163Removed in mature formSequence analysisPRO_0000370813

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycineBy similarity
Lipidationi212 – 2121S-geranylgeranyl cysteineBy similarity
Modified residuei213 – 2131Cysteine methyl esterSequence analysis
Lipidationi213 – 2131S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ5ZJN2.
PRIDEiQ5ZJN2.

Expressioni

Gene expression databases

BgeeiENSGALG00000007615.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000012298.

Structurei

3D structure databases

ProteinModelPortaliQ5ZJN2.
SMRiQ5ZJN2. Positions 8-175.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 489Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0087. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ5ZJN2.
KOiK07904.
OMAiAMGTRDD.
OrthoDBiEOG091G0O1R.
PhylomeDBiQ5ZJN2.
TreeFamiTF300099.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ZJN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNRDDEYDY LFKVVLIGDS GVGKSNLLSR FTRNEFNLES KSTIGVEFAT
60 70 80 90 100
RSIQVDGKTI KAQIWDTAGQ ERYRAITSAY YRGAVGALLV YDIAKHLTYE
110 120 130 140 150
NVERWLKELR DHADSNIVIM LVGNKSDLRH LRAVPTDEAR AFAEKNGLSF
160 170 180 190 200
IETSALDSTN VEAAFQTILT EIYRIVSQKQ MSDRRENDMS PSNNVVPIHV
210
PPTTENKPKM QCCQNI
Length:216
Mass (Da):24,439
Last modified:November 23, 2004 - v1
Checksum:i76BDB0A17B837732
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720402 mRNA. Translation: CAG32061.1.
RefSeqiNP_001005827.1. NM_001005827.1.
UniGeneiGga.5322.

Genome annotation databases

EnsembliENSGALT00000012312; ENSGALP00000012298; ENSGALG00000007615.
GeneIDi415544.
KEGGigga:415544.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720402 mRNA. Translation: CAG32061.1.
RefSeqiNP_001005827.1. NM_001005827.1.
UniGeneiGga.5322.

3D structure databases

ProteinModelPortaliQ5ZJN2.
SMRiQ5ZJN2. Positions 8-175.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000012298.

Proteomic databases

PaxDbiQ5ZJN2.
PRIDEiQ5ZJN2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000012312; ENSGALP00000012298; ENSGALG00000007615.
GeneIDi415544.
KEGGigga:415544.

Organism-specific databases

CTDi8766.

Phylogenomic databases

eggNOGiKOG0087. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ5ZJN2.
KOiK07904.
OMAiAMGTRDD.
OrthoDBiEOG091G0O1R.
PhylomeDBiQ5ZJN2.
TreeFamiTF300099.

Enzyme and pathway databases

ReactomeiR-GGA-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-GGA-5620912. Anchoring of the basal body to the plasma membrane.
R-GGA-5620916. VxPx cargo-targeting to cilium.

Miscellaneous databases

PROiQ5ZJN2.

Gene expression databases

BgeeiENSGALG00000007615.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRB11A_CHICK
AccessioniPrimary (citable) accession number: Q5ZJN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: November 23, 2004
Last modified: September 7, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.