Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Small ubiquitin-related modifier 2

Gene

SUMO2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-GGA-3065679. SUMO is proteolytically processed.
R-GGA-3108214. SUMOylation of DNA damage response and repair proteins.
R-GGA-3232118. SUMOylation of transcription factors.
R-GGA-4551638. SUMOylation of chromatin organization proteins.
R-GGA-4570464. SUMOylation of RNA binding proteins.
R-GGA-4615885. SUMOylation of DNA replication proteins.
R-GGA-5693607. Processing of DNA double-strand break ends.

Names & Taxonomyi

Protein namesi
Recommended name:
Small ubiquitin-related modifier 2
Short name:
SUMO-2
Gene namesi
Name:SUMO2
ORF Names:RCJMB04_17a7
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 18

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9393Small ubiquitin-related modifier 2PRO_0000269467Add
BLAST
Propeptidei94 – 952By similarityPRO_0000269468

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki11 – 11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linki93 – 93Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)PROSITE-ProRule annotation

Post-translational modificationi

Polymeric chains can be formed through Lys-11 cross-linking.By similarity
Cleavage of precursor form by a sentrin-specific protease is necessary for function.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ5ZJM9.
PRIDEiQ5ZJM9.

Expressioni

Gene expression databases

BgeeiENSGALG00000007971.

Interactioni

Subunit structurei

Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins (By similarity).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000012928.

Structurei

3D structure databases

ProteinModelPortaliQ5ZJM9.
SMRiQ5ZJM9. Positions 1-95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 9580Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ubiquitin family. SUMO subfamily.Curated
Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1769. Eukaryota.
COG5227. LUCA.
GeneTreeiENSGT00390000018808.
HOVERGENiHBG053025.
InParanoidiQ5ZJM9.
KOiK12160.
OMAiLMQAYCD.
OrthoDBiEOG091G10ZQ.
PhylomeDBiQ5ZJM9.
TreeFamiTF315116.

Family and domain databases

InterProiIPR022617. Rad60/SUMO-like_dom.
IPR027218. SUMO_chordates.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PANTHERiPTHR10562:SF10. PTHR10562:SF10. 1 hit.
PfamiPF11976. Rad60-SLD. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ZJM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADEKPKEGV KTENNDHINL KVAGQDGSVV QFKIKRHTPL SKLMKAYCER
60 70 80 90
QGLSMRQIRF RFDGQPINET DTPAQLEMED EDTIDVFQQQ TGGVY
Length:95
Mass (Da):10,871
Last modified:November 23, 2004 - v1
Checksum:iF8F0426849BEF08B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720405 mRNA. Translation: CAG32064.1.
RefSeqiNP_001074186.1. NM_001080717.2.
UniGeneiGga.30592.

Genome annotation databases

EnsembliENSGALT00000012943; ENSGALP00000012928; ENSGALG00000007971.
GeneIDi770125.
KEGGigga:770125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720405 mRNA. Translation: CAG32064.1.
RefSeqiNP_001074186.1. NM_001080717.2.
UniGeneiGga.30592.

3D structure databases

ProteinModelPortaliQ5ZJM9.
SMRiQ5ZJM9. Positions 1-95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000012928.

Proteomic databases

PaxDbiQ5ZJM9.
PRIDEiQ5ZJM9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000012943; ENSGALP00000012928; ENSGALG00000007971.
GeneIDi770125.
KEGGigga:770125.

Organism-specific databases

CTDi6613.

Phylogenomic databases

eggNOGiKOG1769. Eukaryota.
COG5227. LUCA.
GeneTreeiENSGT00390000018808.
HOVERGENiHBG053025.
InParanoidiQ5ZJM9.
KOiK12160.
OMAiLMQAYCD.
OrthoDBiEOG091G10ZQ.
PhylomeDBiQ5ZJM9.
TreeFamiTF315116.

Enzyme and pathway databases

ReactomeiR-GGA-3065679. SUMO is proteolytically processed.
R-GGA-3108214. SUMOylation of DNA damage response and repair proteins.
R-GGA-3232118. SUMOylation of transcription factors.
R-GGA-4551638. SUMOylation of chromatin organization proteins.
R-GGA-4570464. SUMOylation of RNA binding proteins.
R-GGA-4615885. SUMOylation of DNA replication proteins.
R-GGA-5693607. Processing of DNA double-strand break ends.

Miscellaneous databases

PROiQ5ZJM9.

Gene expression databases

BgeeiENSGALG00000007971.

Family and domain databases

InterProiIPR022617. Rad60/SUMO-like_dom.
IPR027218. SUMO_chordates.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PANTHERiPTHR10562:SF10. PTHR10562:SF10. 1 hit.
PfamiPF11976. Rad60-SLD. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUMO2_CHICK
AccessioniPrimary (citable) accession number: Q5ZJM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 23, 2004
Last modified: September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.