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Protein

Ubiquitin-like domain-containing CTD phosphatase 1

Gene

UBLCP1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-like domain-containing CTD phosphatase 1 (EC:3.1.3.16)
Alternative name(s):
Nuclear proteasome inhibitor UBLCP1
Gene namesi
Name:UBLCP1
ORF Names:RCJMB04_17j14
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002426441 – 318Ubiquitin-like domain-containing CTD phosphatase 1Add BLAST318

Proteomic databases

PaxDbiQ5ZJJ8.
PRIDEiQ5ZJJ8.

Expressioni

Gene expression databases

BgeeiENSGALG00000003672.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000005808.

Structurei

3D structure databases

ProteinModelPortaliQ5ZJJ8.
SMRiQ5ZJJ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 81Ubiquitin-likePROSITE-ProRule annotationAdd BLAST79
Domaini133 – 294FCP1 homologyPROSITE-ProRule annotationAdd BLAST162

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni133 – 294PhosphataseBy similarityAdd BLAST162

Domaini

The Ubiquitin-like domain mediates interaction with proteasomes.By similarity

Phylogenomic databases

eggNOGiKOG1605. Eukaryota.
KOG1872. Eukaryota.
COG5190. LUCA.
GeneTreeiENSGT00390000010107.
HOGENOMiHOG000231279.
HOVERGENiHBG080207.
InParanoidiQ5ZJJ8.
KOiK17618.
OMAiFKLMMVG.
OrthoDBiEOG091G0CRH.
PhylomeDBiQ5ZJJ8.
TreeFamiTF323786.

Family and domain databases

Gene3Di3.40.50.1000. 1 hit.
InterProiView protein in InterPro
IPR004274. FCP1_dom.
IPR036412. HAD-like_sf.
IPR011943. HAD-SF_hydro_IIID.
IPR023214. HAD_sf.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
PfamiView protein in Pfam
PF03031. NIF. 1 hit.
PF00240. ubiquitin. 1 hit.
SMARTiView protein in SMART
SM00577. CPDc. 1 hit.
SM00213. UBQ. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.
SSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR02245. HAD_IIID1. 1 hit.
PROSITEiView protein in PROSITE
PS50969. FCP1. 1 hit.
PS50053. UBIQUITIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5ZJJ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSLIIKWG GQEYTITSLS EEDTVLDLKQ SLKGLTGVLP ERQKLLGLKM
60 70 80 90 100
KGKPADDDVK LGALKLKPNT KIMMMGTREE SLEDVLGPPP DNDDVINDFD
110 120 130 140 150
IEEEVVEVEN REENLLKISR RVKEYKVEIL NPPREGKKLL VLDVDYTLFD
160 170 180 190 200
HRSCAETGVE LMRPYLHEFL TSAYEDYDIV IWSATNMKWI EAKMKELGVS
210 220 230 240 250
TNANYKITFM LDSAAMITVH TPRRGLIDVK PLGVIWGKFS EYYSKKNTIM
260 270 280 290 300
FDDIGRNFLM NPQNGLKIRP FMKAHLNRDK DKELLKLTQY LKEIAKLDDF
310
LELNHKHWER YLSKKQGQ
Length:318
Mass (Da):36,800
Last modified:November 23, 2004 - v1
Checksum:iFC73F52A7B36668C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720436 mRNA. Translation: CAG32095.1.
RefSeqiNP_001025784.2. NM_001030613.3.
XP_015149251.1. XM_015293765.1.
UniGeneiGga.22390.

Genome annotation databases

EnsembliENSGALT00000005818; ENSGALP00000005808; ENSGALG00000003672.
GeneIDi416237.
KEGGigga:416237.

Similar proteinsi

Entry informationi

Entry nameiUBCP1_CHICK
AccessioniPrimary (citable) accession number: Q5ZJJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 23, 2004
Last modified: October 25, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome