Q5ZJJ8 (UBCP1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin-like domain-containing CTD phosphatase 1
EC=3.1.3.16

Alternative name(s):
Nuclear proteasome inhibitor UBLCP1

Gene names

Name:	UBLCP1
ORF Names:	RCJMB04_17j14

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome By similarity.
Catalytic activity	A phosphoprotein + H2O = a protein + phosphate.
Cofactor	Magnesium By similarity.
Subcellular location	Nucleus By similarity. Note: Colocalizes with nuclear proteasomes By similarity.
Domain	The Ubiquitin-like domain mediates interaction with proteasomes By similarity.
Sequence similarities	Contains 1 FCP1 homology domain. Contains 1 ubiquitin-like domain.

Ontologies

Keywords
Cellular component	Nucleus
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleolus Inferred from electronic annotation. Source: Compara
Molecular_function	phosphoprotein phosphatase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	Ubiquitin-like domain-containing CTD phosphatase 1		PRO_0000242644
Regions
	Domain	3 – 81	79	Ubiquitin-like
	Domain	133 – 294	162	FCP1 homology
	Region	133 – 294	162	Phosphatase By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5ZJJ8 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: FC73F52A7B36668C	FASTA	318	36,800
	10 20 30 40 50 60 MSLSLIIKWG GQEYTITSLS EEDTVLDLKQ SLKGLTGVLP ERQKLLGLKM KGKPADDDVK 70 80 90 100 110 120 LGALKLKPNT KIMMMGTREE SLEDVLGPPP DNDDVINDFD IEEEVVEVEN REENLLKISR 130 140 150 160 170 180 RVKEYKVEIL NPPREGKKLL VLDVDYTLFD HRSCAETGVE LMRPYLHEFL TSAYEDYDIV 190 200 210 220 230 240 IWSATNMKWI EAKMKELGVS TNANYKITFM LDSAAMITVH TPRRGLIDVK PLGVIWGKFS 250 260 270 280 290 300 EYYSKKNTIM FDDIGRNFLM NPQNGLKIRP FMKAHLNRDK DKELLKLTQY LKEIAKLDDF 310 LELNHKHWER YLSKKQGQ

References

[1]

"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis." Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M. Genome Biol. 6:R6.1-R6.9(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: CB. Tissue: Bursa of Fabricius.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ720436 mRNA. Translation: CAG32095.1.
IPI	IPI00589430.
RefSeq	NP_001025784.2. NM_001030613.3.
UniGene	Gga.22390.
3D structure databases
ProteinModelPortal	Q5ZJJ8.
SMR	Q5ZJJ8. Positions 3-79.
ModBase	Search...
Proteomic databases
PaxDb	Q5ZJJ8.
PRIDE	Q5ZJJ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSGALT00000005818; ENSGALP00000005808; ENSGALG00000003672.
GeneID	416237.
KEGG	gga:416237.
Organism-specific databases
CTD	134510.
Phylogenomic databases
eggNOG	NOG310886.
GeneTree	ENSGT00390000010107.
HOGENOM	HOG000231279.
HOVERGEN	HBG080207.
InParanoid	Q5ZJJ8.
KO	K01090.
OMA	KWIDAKM.
OrthoDB	EOG476K0P.
Gene expression databases
ArrayExpress	Q5ZJJ8.
Family and domain databases
Gene3D	3.40.50.1000. 1 hit.
InterPro	IPR023214. HAD-like_dom. IPR011943. HAD-SF_hydro_IIID. IPR004274. NIF. IPR000626. Ubiquitin. IPR019955. Ubiquitin_supergroup. [Graphical view]
Pfam	PF03031. NIF. 1 hit. PF00240. ubiquitin. 1 hit. [Graphical view]
SMART	SM00577. CPDc. 1 hit. SM00213. UBQ. 1 hit. [Graphical view]
SUPFAM	SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR02245. HAD_IIID1. 1 hit.
PROSITE	PS50969. FCP1. 1 hit. PS00299. UBIQUITIN_1. False negative. PS50053. UBIQUITIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20819726.

Entry information

Entry name

UBCP1_CHICK

Accession

Primary (citable) accession number: Q5ZJJ8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	November 23, 2004
Last modified:	April 3, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program