Q5ZJI0 (TPST2_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein-tyrosine sulfotransferase 2
EC=2.8.2.20

Alternative name(s):
Tyrosylprotein sulfotransferase 2
Short name=TPST-2

Gene names

Name:	TPST2
ORF Names:	RCJMB04_17p1

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides By similarity.
Catalytic activity	3'-phosphoadenylyl sulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate.
Subcellular location	Golgi apparatus membrane; Single-pass type II membrane protein By similarity.
Sequence similarities	Belongs to the protein sulfotransferase family.

Ontologies

Keywords
Cellular component	Golgi apparatus Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Transferase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein-tyrosine sulfotransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 371	371	Protein-tyrosine sulfotransferase 2		PRO_0000253726
Regions
	Topological domain	1 – 8	8	Cytoplasmic Potential
	Transmembrane	9 – 25	17	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	26 – 371	346	Lumenal Potential
Amino acid modifications
	Glycosylation	341	1	N-linked (GlcNAc...) Potential
	Glycosylation	366	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5ZJI0 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: A75DCABC66AC4F24	FASTA	371	42,042
	10 20 30 40 50 60 MRVTMRRVLL AVGSVVALMV TLHLGQQVLE CQHVLSKRRH RLMRPENEEL VMVDSNHVEY 70 80 90 100 110 120 RYSKEMPLIF IGGVPRSGTT LMRAMLDAHP EVRCGEETRI IPRVLAMRQA WSKSGREKMR 130 140 150 160 170 180 LDEAGVTDQV LDAAMQAFIL EVIAKHGEPA RYLCNKDPFT LKSSVYLSRL FPNSKFLLMV 190 200 210 220 230 240 RDGRASVHSM ITRKVTIAGF DLNCYRDCLT KWNKAIEVMY SQCLEIGRSR CLPVYYEQLV 250 260 270 280 290 300 LHPEQSMHAI MKFLGISWSD TVLHHEELIG KPGGVSLSKI ERSTDQVIKP VNMEALSKWI 310 320 330 340 350 360 GHIPGDVLQD MAHIAPMLAR LGYDPYANPP NYGHPDPLVV NNTHRVLKGD YKTPANLKGH 370 LQVTQNTSSS H

References

[1]

"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis." Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M. Genome Biol. 6:R6.1-R6.9(2005) [PubMed: 15642098] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: CB. Tissue: Bursa of Fabricius.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ720454 mRNA. Translation: CAG32113.1.
IPI	IPI00576078.
RefSeq	NP_001012812.1. NM_001012794.1.
UniGene	Gga.6013.
3D structure databases
ProteinModelPortal	Q5ZJI0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	416910.
KEGG	gga:416910.
Organism-specific databases
CTD	8459.
Phylogenomic databases
eggNOG	veNOG08516.
GeneTree	ENSGT00390000006030.
HOGENOM	HBG382344.
HOVERGEN	HBG001270.
InParanoid	Q5ZJI0.
OrthoDB	EOG4Z36DX.
Family and domain databases
InterPro	IPR000863. Sulfotransferase_dom. [Graphical view]
KO	K01021.
Pfam	PF00685. Sulfotransfer_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TPST2_CHICK

Accession

Primary (citable) accession number: Q5ZJI0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	November 23, 2004
Last modified:	November 16, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program