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Protein

H/ACA ribonucleoprotein complex subunit 4

Gene

DKC1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for ribosome biogenesis. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).By similarity

Catalytic activityi

RNA uridine = RNA pseudouridine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei123NucleophileBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Ribonucleoprotein, RNA-binding
Biological processRibosome biogenesis, rRNA processing

Enzyme and pathway databases

ReactomeiR-GGA-417076 Assembly of telomerase and telomere extension

Names & Taxonomyi

Protein namesi
Recommended name:
H/ACA ribonucleoprotein complex subunit 4 (EC:5.4.99.-)
Alternative name(s):
Dyskerin
Gene namesi
Name:DKC1
ORF Names:RCJMB04_17p9
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001219861 – 516H/ACA ribonucleoprotein complex subunit 4Add BLAST516

Proteomic databases

PaxDbiQ5ZJH9

Interactioni

Subunit structurei

Component of the small nucleolar ribonucleoprotein particle containing H/ACA-type snoRNAs (H/ACA snoRNPs). Component of the telomerase holoenzyme complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000008091

Structurei

3D structure databases

ProteinModelPortaliQ5ZJH9
SMRiQ5ZJH9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini294 – 369PUAPROSITE-ProRule annotationAdd BLAST76

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili463 – 516Sequence analysisAdd BLAST54

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi468 – 481Poly-LysAdd BLAST14
Compositional biasi500 – 509Poly-Lys10

Sequence similaritiesi

Belongs to the pseudouridine synthase TruB family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2529 Eukaryota
COG0130 LUCA
HOGENOMiHOG000231224
HOVERGENiHBG081442
InParanoidiQ5ZJH9
KOiK11131
PhylomeDBiQ5ZJH9

Family and domain databases

InterProiView protein in InterPro
IPR012960 Dyskerin-like
IPR020103 PsdUridine_synth_cat_dom_sf
IPR002501 PsdUridine_synth_N
IPR002478 PUA
IPR015947 PUA-like_sf
IPR004802 tRNA_PsdUridine_synth_B_fam
IPR032819 TruB_C
IPR004521 Uncharacterised_CHP00451
PANTHERiPTHR23127 PTHR23127, 1 hit
PfamiView protein in Pfam
PF08068 DKCLD, 1 hit
PF01472 PUA, 1 hit
PF16198 TruB_C_2, 1 hit
PF01509 TruB_N, 1 hit
SMARTiView protein in SMART
SM01136 DKCLD, 1 hit
SM00359 PUA, 1 hit
SUPFAMiSSF55120 SSF55120, 1 hit
SSF88697 SSF88697, 1 hit
TIGRFAMsiTIGR00425 CBF5, 1 hit
TIGR00451 unchar_dom_2, 1 hit
PROSITEiView protein in PROSITE
PS50890 PUA, 1 hit

Sequencei

Sequence statusi: Complete.

Q5ZJH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADGDGSSVK KRRKKDKRSL PDEDVADIQH TEEFLIKPES RVAQLDTSQW
60 70 80 90 100
PLLLKNFDKL NVLTTHYTPL PSGANPLKRE ISDYVRSGFI NLDKPSNPSS
110 120 130 140 150
HEVVAWIRRI LRVEKTGHSG TLDPKVTGCL IVCIERATRL VKSQQSAGKE
160 170 180 190 200
YVGIVRLHNA IESEAQLARA IETLTGALFQ RPPLIAAVKR QLRVRTIYES
210 220 230 240 250
KLVEYDPERR LGIFWVSCEA GTYIRTLCVH LGLLLGVGGQ MQELRRVRSG
260 270 280 290 300
ILGEMDNMVT MHDVLDAQWQ YDNNKDDSYL RRVILPLEKL LTSHKRLVMK
310 320 330 340 350
DSAVNAICYG AKIMLPGVLR YEDGIELKQE IVVITTKGEA ICLAIALMTT
360 370 380 390 400
AVISTCDHGV VAKIKRVIME RDTYPRKWGL GPKASQKKMM IQKGLLDKHG
410 420 430 440 450
KPNECTPDSW KKEYVDYRES SKKEAAKVPQ AVSEVERAPK RKRESESENE
460 470 480 490 500
AVSPPPSPAT PPPEELSKKE KKKKKKEKKA KEAAESGEEQ VEVISESSAK
510
KKKKKKKQKE VEESSE
Length:516
Mass (Da):58,150
Last modified:November 23, 2004 - v1
Checksum:iC42EAF2E4866D9DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720455 mRNA Translation: CAG32114.1
RefSeqiNP_001026286.1, NM_001031115.1
UniGeneiGga.1015

Genome annotation databases

GeneIDi422196
KEGGigga:422196

Similar proteinsi

Entry informationi

Entry nameiDKC1_CHICK
AccessioniPrimary (citable) accession number: Q5ZJH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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