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Protein

H/ACA ribonucleoprotein complex subunit 4

Gene

DKC1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Required for ribosome biogenesis. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).By similarity

Catalytic activityi

RNA uridine = RNA pseudouridine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei123 – 1231NucleophileBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Ribonucleoprotein

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-GGA-417076. Assembly of telomerase and telomere extension.

Names & Taxonomyi

Protein namesi
Recommended name:
H/ACA ribonucleoprotein complex subunit 4 (EC:5.4.99.-)
Alternative name(s):
Dyskerin
Gene namesi
Name:DKC1
ORF Names:RCJMB04_17p9
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 516516H/ACA ribonucleoprotein complex subunit 4PRO_0000121986Add
BLAST

Proteomic databases

PaxDbiQ5ZJH9.
PRIDEiQ5ZJH9.

Interactioni

Subunit structurei

Component of the small nucleolar ribonucleoprotein particle containing H/ACA-type snoRNAs (H/ACA snoRNPs). Component of the telomerase holoenzyme complex (By similarity).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000008091.

Structurei

3D structure databases

ProteinModelPortaliQ5ZJH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini294 – 36976PUAPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili463 – 51654Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi468 – 48114Poly-LysAdd
BLAST
Compositional biasi500 – 50910Poly-Lys

Sequence similaritiesi

Belongs to the pseudouridine synthase TruB family.Curated
Contains 1 PUA domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2529. Eukaryota.
COG0130. LUCA.
HOGENOMiHOG000231224.
HOVERGENiHBG081442.
InParanoidiQ5ZJH9.
KOiK11131.
PhylomeDBiQ5ZJH9.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
InterProiIPR012960. Dyskerin-like.
IPR020103. PsdUridine_synth_cat_dom.
IPR002501. PsdUridine_synth_N.
IPR002478. PUA.
IPR015947. PUA-like_domain.
IPR004802. tRNA_PsdUridine_synth_B_fam.
IPR032819. TruB_C.
IPR004521. Uncharacterised_CHP00451.
[Graphical view]
PANTHERiPTHR23127. PTHR23127. 1 hit.
PfamiPF08068. DKCLD. 1 hit.
PF01472. PUA. 1 hit.
PF16198. TruB_C_2. 1 hit.
PF01509. TruB_N. 1 hit.
[Graphical view]
SMARTiSM01136. DKCLD. 1 hit.
SM00359. PUA. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00425. CBF5. 1 hit.
TIGR00451. unchar_dom_2. 1 hit.
PROSITEiPS50890. PUA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZJH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADGDGSSVK KRRKKDKRSL PDEDVADIQH TEEFLIKPES RVAQLDTSQW
60 70 80 90 100
PLLLKNFDKL NVLTTHYTPL PSGANPLKRE ISDYVRSGFI NLDKPSNPSS
110 120 130 140 150
HEVVAWIRRI LRVEKTGHSG TLDPKVTGCL IVCIERATRL VKSQQSAGKE
160 170 180 190 200
YVGIVRLHNA IESEAQLARA IETLTGALFQ RPPLIAAVKR QLRVRTIYES
210 220 230 240 250
KLVEYDPERR LGIFWVSCEA GTYIRTLCVH LGLLLGVGGQ MQELRRVRSG
260 270 280 290 300
ILGEMDNMVT MHDVLDAQWQ YDNNKDDSYL RRVILPLEKL LTSHKRLVMK
310 320 330 340 350
DSAVNAICYG AKIMLPGVLR YEDGIELKQE IVVITTKGEA ICLAIALMTT
360 370 380 390 400
AVISTCDHGV VAKIKRVIME RDTYPRKWGL GPKASQKKMM IQKGLLDKHG
410 420 430 440 450
KPNECTPDSW KKEYVDYRES SKKEAAKVPQ AVSEVERAPK RKRESESENE
460 470 480 490 500
AVSPPPSPAT PPPEELSKKE KKKKKKEKKA KEAAESGEEQ VEVISESSAK
510
KKKKKKKQKE VEESSE
Length:516
Mass (Da):58,150
Last modified:November 23, 2004 - v1
Checksum:iC42EAF2E4866D9DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720455 mRNA. Translation: CAG32114.1.
RefSeqiNP_001026286.1. NM_001031115.1.
UniGeneiGga.1015.

Genome annotation databases

GeneIDi422196.
KEGGigga:422196.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720455 mRNA. Translation: CAG32114.1.
RefSeqiNP_001026286.1. NM_001031115.1.
UniGeneiGga.1015.

3D structure databases

ProteinModelPortaliQ5ZJH9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000008091.

Proteomic databases

PaxDbiQ5ZJH9.
PRIDEiQ5ZJH9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi422196.
KEGGigga:422196.

Organism-specific databases

CTDi1736.

Phylogenomic databases

eggNOGiKOG2529. Eukaryota.
COG0130. LUCA.
HOGENOMiHOG000231224.
HOVERGENiHBG081442.
InParanoidiQ5ZJH9.
KOiK11131.
PhylomeDBiQ5ZJH9.

Enzyme and pathway databases

ReactomeiR-GGA-417076. Assembly of telomerase and telomere extension.

Miscellaneous databases

PROiQ5ZJH9.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
InterProiIPR012960. Dyskerin-like.
IPR020103. PsdUridine_synth_cat_dom.
IPR002501. PsdUridine_synth_N.
IPR002478. PUA.
IPR015947. PUA-like_domain.
IPR004802. tRNA_PsdUridine_synth_B_fam.
IPR032819. TruB_C.
IPR004521. Uncharacterised_CHP00451.
[Graphical view]
PANTHERiPTHR23127. PTHR23127. 1 hit.
PfamiPF08068. DKCLD. 1 hit.
PF01472. PUA. 1 hit.
PF16198. TruB_C_2. 1 hit.
PF01509. TruB_N. 1 hit.
[Graphical view]
SMARTiSM01136. DKCLD. 1 hit.
SM00359. PUA. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00425. CBF5. 1 hit.
TIGR00451. unchar_dom_2. 1 hit.
PROSITEiPS50890. PUA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiDKC1_CHICK
AccessioniPrimary (citable) accession number: Q5ZJH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: November 23, 2004
Last modified: June 8, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.