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Reviewed, UniProtKB/Swiss-Prot Q5ZJF4 (PRDX6_CHICK)

Last modified June 16, 2009. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Peroxiredoxin-6
    EC=1.11.1.15
Gene names
Name: PRDX6
ORF Names: RCJMB04_18k11
OrganismGallus gallus (Chicken)
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length224 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Involved in redox regulation of the cell. Can reduce H2O2 and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury By similarity.

Catalytic activity

2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity. Lysosome By similarity. Cytoplasmic vesicle By similarity.

Miscellaneous

The active site is the redox-active Cys-46 oxidized to Cys-SOH. Cys-SOH may rapidly react with a Cys-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin By similarity.

Irreversibly inactivated by overoxidation of Cys-46 (to Cys-SO3H) upon oxidative stress By similarity.

Sequence similarities

Belongs to the ahpC/TSA family. Rehydrin subfamily.

Contains 1 thioredoxin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 224223Peroxiredoxin-6
PRO_0000256863

Regions

Domain4 – 168165Thioredoxin

Sites

Active site311For phospholipase activity By similarity
Active site461Cysteine sulfenic acid (-SOH) intermediate By similarity

Amino acid modifications

Modified residue881Phosphotyrosine By similarity
Disulfide bond46Interchain; in linked form By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5ZJF4-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 4F2759FB44EC9493

FASTA22424,977
        10         20         30         40         50         60 
MPGLLLGDEA PNFEADTTQG GIRFHDFLGD SWGILFSHPR DFTPVCTTEL GRAAKLAPEF 

        70         80         90        100        110        120 
SKRNVKMIAL SIDSVPDHLA WSKDINAYNG DQPVEKLPFP IIADKDRELA VKLGMLDPDE 

       130        140        150        160        170        180 
RDKDGMPLTA RVVFIFGPDK KLKLSILYPA TTGRNFDEIL RVVDSLQLTA YKKVATPVDW 

       190        200        210        220 
KCGDSVMVVP TLPDEEAKKL FPKGVFTKDL PSGKKYLRYT PQPE 

« Hide

References

[1]"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis."
Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.
Genome Biol. 6:RESEARCH006.1-RESEARCH006.9(2005) [PubMed: 15642098] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: CB.
Tissue: Bursa of Fabricius.

Cross-references

Sequence databases

AJ720480 mRNA. Translation: CAG32139.1.
IPIIPI00577013.
RefSeqNP_001034418.1.
UniGeneGga.34325

3D structure databases

SMRQ5ZJF4. Positions 3-222, 4-223.
ModBaseSearch...

Protein family/group databases

PeroxiBase4421. Gga1CysPrx.

Genome annotation databases

EnsemblENSGALG00000003053. Gallus gallus. [Contig view]
GeneID429062.
KEGGgga:429062.

Phylogenomic databases

HOVERGENQ5ZJF4.

Enzyme and pathway databases

BRENDA1.11.1.15. 4.

Family and domain databases

InterProIPR000866. Alkyl_hydroperoxide_Rdtase.
IPR019479. Peroxiredoxin_C.
IPR017936. Thioredoxin-like.
IPR012335. Thioredoxin_fold.
[Graphical view]
Gene3DG3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PfamPF10417. 1-cysPrx_C. 1 hit.
PF00578. AhpC-TSA. 1 hit.
[Graphical view]
PROSITEPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePRDX6_CHICK
AccessionPrimary (citable) accession number: Q5ZJF4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: January 23, 2007
Last modified: June 16, 2009
This is version 41 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents