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Q5ZJ66

- SYEM_CHICK

UniProt

Q5ZJ66 - SYEM_CHICK

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Protein
Probable glutamate--tRNA ligase, mitochondrial
Gene
EARS2, RCJMB04_20f12
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) By similarity.UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei29 – 291ATP By similarity
Binding sitei55 – 551Glutamate By similarity
Binding sitei225 – 2251Glutamate By similarity
Binding sitei228 – 2281ATP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi263 – 2675ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-tRNA ligase activity Source: UniProtKB-EC
  3. tRNA binding Source: InterPro

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutamate--tRNA ligase, mitochondrial (EC:6.1.1.17)
Alternative name(s):
Glutamyl-tRNA synthetase
Short name:
GluRS
Gene namesi
Name:EARS2
ORF Names:RCJMB04_20f12
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Mitochondrion matrix By similarity UniRule annotation

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2020Mitochondrion Reviewed prediction
Add
BLAST
Chaini21 – 502482Probable glutamate--tRNA ligase, mitochondrialUniRule annotation
PRO_0000254563Add
BLAST

Proteomic databases

PaxDbiQ5ZJ66.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000009866.

Structurei

3D structure databases

ProteinModelPortaliQ5ZJ66.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni19 – 213Glutamate binding By similarity
Regioni207 – 2115Glutamate binding By similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi24 – 329"HIGH" regionUniRule annotation
Motifi263 – 2675"KMSKS" regionUniRule annotation

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000252720.
HOVERGENiHBG056174.
InParanoidiQ5ZJ66.
KOiK01885.
PhylomeDBiQ5ZJ66.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_B. Glu_tRNA_synth_B.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ZJ66-1 [UniParc]FASTAAdd to Basket

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MAGMLREVCG AAASGLRVRF GPSPTGFLHL GGLRTALYNY VFAKQQRGTF    50
VLRVEDTDQG RVVAGAAESI EDMLHWAGIP PDESPRRGGP FGPYQQSLRL 100
DLYRAASEAL LDRGAAYRCF CTPQRLELLR KEALRNQQTP RYDNRCRHLT 150
PKEVAEKLAQ GLDWVVRFRL ERGVEPFQDL VYGWNKHEVA EVEGDPVILK 200
ADGFPTYHLA NVVDDHHMGI SHVLRGTEWL TSTSKHLLLY KAFGWDPPQF 250
GHLPLLLNKD GSKLSKRQGD IFLERFAQEG YLPEALLDMI TNCGSGFAEK 300
QMGRTLEELI SQFEIGRITT HSALLDLEKL PEFNRMHLTR HIENEGLRQK 350
LIQELQLLVE DVYGDQEVDK EVLEKEYVEQ VLLLRKGHIS HLKDLVSDNY 400
SYLWVRPSVS REQLQMISAE VDEIGKLVLG LMTKPAAVWT IEELNKDLRS 450
LQKQTRETKY SSMMKLLRLA LSGQQHGPSV AEMMVTLGPR EVCGRISKVL 500
SS 502
Length:502
Mass (Da):56,954
Last modified:November 23, 2004 - v1
Checksum:i1E84C3BB0E744570
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ720568 mRNA. Translation: CAG32227.1.
RefSeqiNP_001026638.1. NM_001031467.1.
UniGeneiGga.22559.

Genome annotation databases

GeneIDi427672.
KEGGigga:427672.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ720568 mRNA. Translation: CAG32227.1 .
RefSeqi NP_001026638.1. NM_001031467.1.
UniGenei Gga.22559.

3D structure databases

ProteinModelPortali Q5ZJ66.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000009866.

Proteomic databases

PaxDbi Q5ZJ66.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 427672.
KEGGi gga:427672.

Organism-specific databases

CTDi 124454.

Phylogenomic databases

eggNOGi COG0008.
HOGENOMi HOG000252720.
HOVERGENi HBG056174.
InParanoidi Q5ZJ66.
KOi K01885.
PhylomeDBi Q5ZJ66.

Miscellaneous databases

NextBioi 20828882.
PROi Q5ZJ66.

Family and domain databases

Gene3Di 1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_B. Glu_tRNA_synth_B.
InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF48163. SSF48163. 1 hit.
TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiSYEM_CHICK
AccessioniPrimary (citable) accession number: Q5ZJ66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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