Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5ZJ60

- HIBCH_CHICK

UniProt

Q5ZJ60 - HIBCH_CHICK

Protein

3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

Gene

HIBCH

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA By similarity.By similarity

    Catalytic activityi

    3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei120 – 1201SubstrateBy similarity
    Binding sitei145 – 1451Substrate; via amide nitrogenBy similarity
    Binding sitei168 – 1681SubstrateBy similarity
    Binding sitei176 – 1761SubstrateBy similarity

    GO - Molecular functioni

    1. 3-hydroxyisobutyryl-CoA hydrolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. valine catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Branched-chain amino acid catabolism

    Enzyme and pathway databases

    UniPathwayiUPA00362.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (EC:3.1.2.4)
    Alternative name(s):
    3-hydroxyisobutyryl-coenzyme A hydrolase
    Short name:
    HIB-CoA hydrolase
    Short name:
    HIBYL-CoA-H
    Gene namesi
    Name:HIBCH
    ORF Names:RCJMB04_20j11
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 3853-hydroxyisobutyryl-CoA hydrolase, mitochondrialPRO_0000284932
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    PaxDbiQ5ZJ60.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000003623.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5ZJ60.
    SMRiQ5ZJ60. Positions 31-385.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1024.
    HOGENOMiHOG000217005.
    HOVERGENiHBG054809.
    InParanoidiQ5ZJ60.
    KOiK05605.
    PhylomeDBiQ5ZJ60.

    Family and domain databases

    Gene3Di1.10.12.10. 1 hit.
    3.90.226.10. 1 hit.
    InterProiIPR029045. ClpP/crotonase-like_dom.
    IPR014748. Crontonase_C.
    [Graphical view]
    SUPFAMiSSF52096. SSF52096. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q5ZJ60-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAARVLMAPR RLKPFNRLQV ILQHLKTCKH TDSAADVLLQ KQGGAGIITL    50
    NRPKVLNALS FKMIQQIYPQ IKAWEQDPET FLIIIKGTGE KAFCAGGDVR 100
    AIADAGKAGD TMTRDYFREE YRLDNAIGTC KKPYVALIDG ITMGGGVGLS 150
    VHGHFRVATE KTVFAMPETA IGLFPDVGGG YFLPRLSGKI GHLLALTGFR 200
    LKGRDVLKAG IATHFVESGK LPELEKDLIA LKSPSKENIA DLLNSYHMQT 250
    KIDQEKEFVL DEHMERINSI FSANSMEEIV QKLKQDGSPF ATKQLEAINK 300
    MSPTSLKLTL RQLREGATMS LQDVFTMEYR LSQACMRGHD FYEGVRAVLI 350
    DKDQSPRWKP AALEEVSDEF VDNCFKPLGN NDLKL 385
    Length:385
    Mass (Da):42,829
    Last modified:November 23, 2004 - v1
    Checksum:iC9737F7C2F3DE7DA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ720574 mRNA. Translation: CAG32233.1.
    RefSeqiNP_001026414.1. NM_001031243.1.
    UniGeneiGga.9512.

    Genome annotation databases

    GeneIDi423979.
    KEGGigga:423979.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ720574 mRNA. Translation: CAG32233.1 .
    RefSeqi NP_001026414.1. NM_001031243.1.
    UniGenei Gga.9512.

    3D structure databases

    ProteinModelPortali Q5ZJ60.
    SMRi Q5ZJ60. Positions 31-385.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000003623.

    Proteomic databases

    PaxDbi Q5ZJ60.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 423979.
    KEGGi gga:423979.

    Organism-specific databases

    CTDi 26275.

    Phylogenomic databases

    eggNOGi COG1024.
    HOGENOMi HOG000217005.
    HOVERGENi HBG054809.
    InParanoidi Q5ZJ60.
    KOi K05605.
    PhylomeDBi Q5ZJ60.

    Enzyme and pathway databases

    UniPathwayi UPA00362 .

    Miscellaneous databases

    NextBioi 20826370.
    PROi Q5ZJ60.

    Family and domain databases

    Gene3Di 1.10.12.10. 1 hit.
    3.90.226.10. 1 hit.
    InterProi IPR029045. ClpP/crotonase-like_dom.
    IPR014748. Crontonase_C.
    [Graphical view ]
    SUPFAMi SSF52096. SSF52096. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: CB.
      Tissue: Bursa of Fabricius.

    Entry informationi

    Entry nameiHIBCH_CHICK
    AccessioniPrimary (citable) accession number: Q5ZJ60
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3