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Q5ZJ60

- HIBCH_CHICK

UniProt

Q5ZJ60 - HIBCH_CHICK

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Protein

3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

Gene
HIBCH, RCJMB04_20j11
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA By similarity.

Catalytic activityi

3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei120 – 1201Substrate By similarity
Binding sitei145 – 1451Substrate; via amide nitrogen By similarity
Binding sitei168 – 1681Substrate By similarity
Binding sitei176 – 1761Substrate By similarity

GO - Molecular functioni

  1. 3-hydroxyisobutyryl-CoA hydrolase activity Source: UniProtKB-EC

GO - Biological processi

  1. valine catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Branched-chain amino acid catabolism

Enzyme and pathway databases

UniPathwayiUPA00362.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (EC:3.1.2.4)
Alternative name(s):
3-hydroxyisobutyryl-coenzyme A hydrolase
Short name:
HIB-CoA hydrolase
Short name:
HIBYL-CoA-H
Gene namesi
Name:HIBCH
ORF Names:RCJMB04_20j11
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 3853-hydroxyisobutyryl-CoA hydrolase, mitochondrialPRO_0000284932
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Proteomic databases

PaxDbiQ5ZJ60.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000003623.

Structurei

3D structure databases

ProteinModelPortaliQ5ZJ60.
SMRiQ5ZJ60. Positions 31-385.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1024.
HOGENOMiHOG000217005.
HOVERGENiHBG054809.
InParanoidiQ5ZJ60.
KOiK05605.
PhylomeDBiQ5ZJ60.

Family and domain databases

Gene3Di1.10.12.10. 1 hit.
3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR014748. Crontonase_C.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ZJ60-1 [UniParc]FASTAAdd to Basket

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MAARVLMAPR RLKPFNRLQV ILQHLKTCKH TDSAADVLLQ KQGGAGIITL    50
NRPKVLNALS FKMIQQIYPQ IKAWEQDPET FLIIIKGTGE KAFCAGGDVR 100
AIADAGKAGD TMTRDYFREE YRLDNAIGTC KKPYVALIDG ITMGGGVGLS 150
VHGHFRVATE KTVFAMPETA IGLFPDVGGG YFLPRLSGKI GHLLALTGFR 200
LKGRDVLKAG IATHFVESGK LPELEKDLIA LKSPSKENIA DLLNSYHMQT 250
KIDQEKEFVL DEHMERINSI FSANSMEEIV QKLKQDGSPF ATKQLEAINK 300
MSPTSLKLTL RQLREGATMS LQDVFTMEYR LSQACMRGHD FYEGVRAVLI 350
DKDQSPRWKP AALEEVSDEF VDNCFKPLGN NDLKL 385
Length:385
Mass (Da):42,829
Last modified:November 23, 2004 - v1
Checksum:iC9737F7C2F3DE7DA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ720574 mRNA. Translation: CAG32233.1.
RefSeqiNP_001026414.1. NM_001031243.1.
UniGeneiGga.9512.

Genome annotation databases

GeneIDi423979.
KEGGigga:423979.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ720574 mRNA. Translation: CAG32233.1 .
RefSeqi NP_001026414.1. NM_001031243.1.
UniGenei Gga.9512.

3D structure databases

ProteinModelPortali Q5ZJ60.
SMRi Q5ZJ60. Positions 31-385.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000003623.

Proteomic databases

PaxDbi Q5ZJ60.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 423979.
KEGGi gga:423979.

Organism-specific databases

CTDi 26275.

Phylogenomic databases

eggNOGi COG1024.
HOGENOMi HOG000217005.
HOVERGENi HBG054809.
InParanoidi Q5ZJ60.
KOi K05605.
PhylomeDBi Q5ZJ60.

Enzyme and pathway databases

UniPathwayi UPA00362 .

Miscellaneous databases

NextBioi 20826370.
PROi Q5ZJ60.

Family and domain databases

Gene3Di 1.10.12.10. 1 hit.
3.90.226.10. 1 hit.
InterProi IPR029045. ClpP/crotonase-like_dom.
IPR014748. Crontonase_C.
[Graphical view ]
SUPFAMi SSF52096. SSF52096. 2 hits.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiHIBCH_CHICK
AccessioniPrimary (citable) accession number: Q5ZJ60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: November 23, 2004
Last modified: June 11, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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