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Q5ZJ58 (PI51B_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphatidylinositol 4-phosphate 5-kinase type-1 beta

Short name=PIP5K1-beta
Short name=PtdIns(4)P-5-kinase 1 beta
EC=2.7.1.68
Alternative name(s):
Phosphatidylinositol 4-phosphate 5-kinase type I beta
Short name=PIP5KIbeta
Type I phosphatidylinositol 4-phosphate 5-kinase beta
Gene names
Name:PIP5K1B
ORF Names:RCJMB04_20j15
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length540 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates reorganization of actin filaments By similarity.

Catalytic activity

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

Subcellular location

Endomembrane system By similarity. Note: Associated with membranes By similarity.

Sequence similarities

Contains 1 PIPK domain.

Ontologies

Keywords
   Cellular componentMembrane
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentendomembrane system

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_function1-phosphatidylinositol-4-phosphate 5-kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

ATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 540540Phosphatidylinositol 4-phosphate 5-kinase type-1 beta
PRO_0000185461

Regions

Domain25 – 395371PIPK

Sequences

Sequence LengthMass (Da)Tools
Q5ZJ58 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 5F9720849533D784

FASTA54060,719
        10         20         30         40         50         60 
MSSVTENGDV TAGKPNEEKT YKKTTSSAIK GAIQLGIGYT VGNLTSKPDR DVLMQDFYVV 

        70         80         90        100        110        120 
ESVFLPSEGS NLTPAHHYPD FRFKTYAPLA FRYFRELFGI KPDDYLYSIC SEPLIELSNP 

       130        140        150        160        170        180 
GASGSLFFVT SDDEFIIKTV QHKEAEFLQK LLPGYYMNLN QNPRTLLPKF YGLYCVQSGG 

       190        200        210        220        230        240 
INIRIVVMNN VLPRALKMNF TYDLKGSTYK RRASRKEREK SNPTFKDLDF LQDMHEGLYF 

       250        260        270        280        290        300 
DSETHSALMK TLQRDCRVLE SFKIMDYSLL LGIHVLNSNV REKEGESSQN ASDGKRPGGQ 

       310        320        330        340        350        360 
KVLYSTAMES IQGPGKSGDS VVTETTNTMG GIPAKSHKGE KLLLFMGIID ILQSYRLMKK 

       370        380        390        400        410        420 
LEHSWKALVY DGDTVSVHRP SFYADRFLKF MNTRVFKKVQ ALRSSPSKKR CNSITALKAT 

       430        440        450        460        470        480 
SQEIVSAVSQ EWKDEKHSII TEGQSYSSLD EEVLGSRRRP DLVPSTPSLF EAASLATTVS 

       490        500        510        520        530        540 
SSSLNVDERY QRDQTMLYSS SKELPSSSTF TLEDSAIYLT SEQSTLETEN DNASVLDVYL 

« Hide

References

[1]"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis."
Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.
Genome Biol. 6:R6.1-R6.9(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: CB.
Tissue: Bursa of Fabricius.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ720576 mRNA. Translation: CAG32235.1.
RefSeqNP_001026593.1. NM_001031422.1.
UniGeneGga.17037.

3D structure databases

ProteinModelPortalQ5ZJ58.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000037435.

Proteomic databases

PaxDbQ5ZJ58.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID427243.
KEGGgga:427243.

Organism-specific databases

CTD8395.

Phylogenomic databases

eggNOGCOG5253.
HOGENOMHOG000193876.
HOVERGENHBG052818.
InParanoidQ5ZJ58.
KOK00889.
PhylomeDBQ5ZJ58.

Family and domain databases

Gene3D3.30.800.10. 1 hit.
3.30.810.10. 1 hit.
InterProIPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR016034. PInositol-4P-5-kinase_core_sub.
[Graphical view]
PANTHERPTHR23086. PTHR23086. 1 hit.
PfamPF01504. PIP5K. 1 hit.
[Graphical view]
SMARTSM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEPS51455. PIPK. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20828532.
PROQ5ZJ58.

Entry information

Entry namePI51B_CHICK
AccessionPrimary (citable) accession number: Q5ZJ58
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families