Reviewed, UniProtKB/Swiss-Prot Q5ZJ58 (PI51B_CHICK)

Names and origin

Protein names

Recommended name:
    Phosphatidylinositol-4-phosphate 5-kinase type-1 beta
    EC=2.7.1.68
Alternative name(s):
    Phosphatidylinositol-4-phosphate 5-kinase type I beta
      Short name=PtdIns(4)P-5-kinase beta
      Short name=PIP5KIbeta
    Type I phosphatidylinositol-4-phosphate 5-kinase beta

Gene names

Name:	PIP5K1B
ORF Names:	RCJMB04_20j15

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	540 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Participates in the biosynthesis of phosphatidylinositol-4,5-bisphosphate. Mediates reorganization of actin filaments By similarity.
Catalytic activity	ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
Subcellular location	Endomembrane system By similarity. Note: Associated with membranes By similarity.
Sequence similarities	Contains 1 PIPK domain.

Ontologies

Keywords
Cellular component	Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	phosphatidylinositol metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	endomembrane system Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-phosphatidylinositol-4-phosphate 5-kinase activity Inferred from electronic annotation. Source: EC ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 540	540	Phosphatidylinositol-4-phosphate 5-kinase type-1 beta		PRO_0000185461
Regions
	Domain	25 – 395	371	PIPK

Sequences

	Sequence		Length	Mass (Da)
	Q5ZJ58-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 5F9720849533D784	FASTA	540	60,719
	10 20 30 40 50 60 MSSVTENGDV TAGKPNEEKT YKKTTSSAIK GAIQLGIGYT VGNLTSKPDR DVLMQDFYVV 70 80 90 100 110 120 ESVFLPSEGS NLTPAHHYPD FRFKTYAPLA FRYFRELFGI KPDDYLYSIC SEPLIELSNP 130 140 150 160 170 180 GASGSLFFVT SDDEFIIKTV QHKEAEFLQK LLPGYYMNLN QNPRTLLPKF YGLYCVQSGG 190 200 210 220 230 240 INIRIVVMNN VLPRALKMNF TYDLKGSTYK RRASRKEREK SNPTFKDLDF LQDMHEGLYF 250 260 270 280 290 300 DSETHSALMK TLQRDCRVLE SFKIMDYSLL LGIHVLNSNV REKEGESSQN ASDGKRPGGQ 310 320 330 340 350 360 KVLYSTAMES IQGPGKSGDS VVTETTNTMG GIPAKSHKGE KLLLFMGIID ILQSYRLMKK 370 380 390 400 410 420 LEHSWKALVY DGDTVSVHRP SFYADRFLKF MNTRVFKKVQ ALRSSPSKKR CNSITALKAT 430 440 450 460 470 480 SQEIVSAVSQ EWKDEKHSII TEGQSYSSLD EEVLGSRRRP DLVPSTPSLF EAASLATTVS 490 500 510 520 530 540 SSSLNVDERY QRDQTMLYSS SKELPSSSTF TLEDSAIYLT SEQSTLETEN DNASVLDVYL

References

[1]

"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis." Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M. Genome Biol. 6:RESEARCH006.1-RESEARCH006.9(2005) [PubMed: 15642098] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: CB. Tissue: Bursa of Fabricius.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ720576 mRNA. Translation: CAG32235.1.
IPI	IPI00603231.
RefSeq	NP_001026593.1.
UniGene	Gga.17037
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5ZJ58.
Genome annotation databases
Ensembl	ENSGALT00000038229; ENSGALP00000037435; ENSGALG00000015107; Gallus gallus. [Genome view]
GeneID	427243.
KEGG	gga:427243.
Organism-specific databases
CTD	427243.
Phylogenomic databases
HOVERGEN	Q5ZJ58.
Enzyme and pathway databases
BRENDA	2.7.1.68. 4.
Family and domain databases
InterPro	IPR002498. PInositol-4-P-5-kinase_core. IPR016034. PInositol-4P-5-kinase_core_sub. [Graphical view]
PANTHER	PTHR23086. PIP5K. 1 hit.
Pfam	PF01504. PIP5K. 1 hit. [Graphical view]
SMART	SM00330. PIPKc. 1 hit. [Graphical view]
PROSITE	PS51455. PIPK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PI51B_CHICK

Accession

Primary (citable) accession number: Q5ZJ58

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2005
Last sequence update:	November 23, 2004
Last modified:	October 13, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)