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Protein

Phosphatidylinositol 4-phosphate 5-kinase type-1 beta

Gene

PIP5K1B

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Mediates reorganization of actin filaments (By similarity).By similarity

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 5-kinase type-1 beta (EC:2.7.1.68)
Short name:
PIP5K1-beta
Short name:
PtdIns(4)P-5-kinase 1 beta
Alternative name(s):
Phosphatidylinositol 4-phosphate 5-kinase type I beta
Short name:
PIP5KIbeta
Type I phosphatidylinositol 4-phosphate 5-kinase beta
Gene namesi
Name:PIP5K1B
ORF Names:RCJMB04_20j15
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001854611 – 540Phosphatidylinositol 4-phosphate 5-kinase type-1 betaAdd BLAST540

Proteomic databases

PaxDbiQ5ZJ58.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000037435.

Structurei

3D structure databases

ProteinModelPortaliQ5ZJ58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 395PIPKPROSITE-ProRule annotationAdd BLAST371

Sequence similaritiesi

Contains 1 PIPK domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0229. Eukaryota.
COG5253. LUCA.
HOGENOMiHOG000193876.
HOVERGENiHBG052818.
InParanoidiQ5ZJ58.
KOiK00889.
PhylomeDBiQ5ZJ58.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 1 hit.
InterProiIPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiPF01504. PIP5K. 1 hit.
[Graphical view]
SMARTiSM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZJ58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSVTENGDV TAGKPNEEKT YKKTTSSAIK GAIQLGIGYT VGNLTSKPDR
60 70 80 90 100
DVLMQDFYVV ESVFLPSEGS NLTPAHHYPD FRFKTYAPLA FRYFRELFGI
110 120 130 140 150
KPDDYLYSIC SEPLIELSNP GASGSLFFVT SDDEFIIKTV QHKEAEFLQK
160 170 180 190 200
LLPGYYMNLN QNPRTLLPKF YGLYCVQSGG INIRIVVMNN VLPRALKMNF
210 220 230 240 250
TYDLKGSTYK RRASRKEREK SNPTFKDLDF LQDMHEGLYF DSETHSALMK
260 270 280 290 300
TLQRDCRVLE SFKIMDYSLL LGIHVLNSNV REKEGESSQN ASDGKRPGGQ
310 320 330 340 350
KVLYSTAMES IQGPGKSGDS VVTETTNTMG GIPAKSHKGE KLLLFMGIID
360 370 380 390 400
ILQSYRLMKK LEHSWKALVY DGDTVSVHRP SFYADRFLKF MNTRVFKKVQ
410 420 430 440 450
ALRSSPSKKR CNSITALKAT SQEIVSAVSQ EWKDEKHSII TEGQSYSSLD
460 470 480 490 500
EEVLGSRRRP DLVPSTPSLF EAASLATTVS SSSLNVDERY QRDQTMLYSS
510 520 530 540
SKELPSSSTF TLEDSAIYLT SEQSTLETEN DNASVLDVYL
Length:540
Mass (Da):60,719
Last modified:November 23, 2004 - v1
Checksum:i5F9720849533D784
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720576 mRNA. Translation: CAG32235.1.
RefSeqiNP_001026593.1. NM_001031422.1.
UniGeneiGga.17037.

Genome annotation databases

GeneIDi427243.
KEGGigga:427243.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720576 mRNA. Translation: CAG32235.1.
RefSeqiNP_001026593.1. NM_001031422.1.
UniGeneiGga.17037.

3D structure databases

ProteinModelPortaliQ5ZJ58.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000037435.

Proteomic databases

PaxDbiQ5ZJ58.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi427243.
KEGGigga:427243.

Organism-specific databases

CTDi8395.

Phylogenomic databases

eggNOGiKOG0229. Eukaryota.
COG5253. LUCA.
HOGENOMiHOG000193876.
HOVERGENiHBG052818.
InParanoidiQ5ZJ58.
KOiK00889.
PhylomeDBiQ5ZJ58.

Miscellaneous databases

PROiQ5ZJ58.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 1 hit.
InterProiIPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiPF01504. PIP5K. 1 hit.
[Graphical view]
SMARTiSM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPI51B_CHICK
AccessioniPrimary (citable) accession number: Q5ZJ58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: November 23, 2004
Last modified: June 8, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.