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Protein

T-complex protein 1 subunit zeta

Gene

CCT6

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-GGA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit zeta
Short name:
TCP-1-zeta
Alternative name(s):
CCT-zeta
Gene namesi
Name:CCT6By similarity
ORF Names:RCJMB04_20k5
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 530529T-complex protein 1 subunit zetaPRO_0000223483Add
BLAST

Proteomic databases

PaxDbiQ5ZJ54.
PRIDEiQ5ZJ54.

Expressioni

Gene expression databases

BgeeiENSGALG00000002448.
ExpressionAtlasiQ5ZJ54. baseline.

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG (By similarity).By similarity

Protein-protein interaction databases

BioGridi678874. 1 interaction.
STRINGi9031.ENSGALP00000003850.

Structurei

3D structure databases

ProteinModelPortaliQ5ZJ54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Sequence analysis

Phylogenomic databases

eggNOGiKOG0359. Eukaryota.
ENOG410XQ3Q. LUCA.
HOGENOMiHOG000226733.
HOVERGENiHBG103725.
InParanoidiQ5ZJ54.
KOiK09498.
OMAiEPMKPVD.
OrthoDBiEOG091G07CE.
PhylomeDBiQ5ZJ54.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012722. Chap_CCT_zeta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02347. chap_CCT_zeta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ZJ54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVKALNPKA EVARAQAALA VNISAARGLQ DVLRTNLGPK GTMKMLVSGA
60 70 80 90 100
GDIKLTKDGN VLLQEMQIQH PTASLIAKVA TAQDDITGDG TTSNVLIIGE
110 120 130 140 150
LLKQADLYIS EGLHPRIVAE GFEIAKEKAL EVLEQVKVTK EMDRETLIDV
160 170 180 190 200
AKTSLRTKVH TELADILTEA VVDSVLAVRK PGEPIDLHMV EIMEMKHKSE
210 220 230 240 250
TDTTLIRGLV LDHGARHPDM KKRVEDAYIL TCNVSLEYEK TEVSAGFFYK
260 270 280 290 300
SAEEREKLVK AERKFIEDRV SKIIDLKRRV CGDSDKGFIV INQKGIDPFS
310 320 330 340 350
LDALAKEGIV ALRRAKRRNM ERLTLACGGT AMNSVEDLTP DCLGHAGLVY
360 370 380 390 400
EYTLGEEKYT FIEKCDNPRS VTLLIRGPNK HTLTQIKDAV RDGLRAVKNA
410 420 430 440 450
IEDGCVIPGA GALEVAVANA LVKHKPNVKG RAQLGVQAFA DALLIIPKVL
460 470 480 490 500
AQNSGYDPQE TLVKVQAEHA ESGQLTGVDL NTGEPMVAAA AGIWDNYNVK
510 520 530
KQLLHSCTVI ASNILLVDEI MRAGMSSLKG
Length:530
Mass (Da):57,645
Last modified:January 23, 2007 - v3
Checksum:i8B8F639A186F12EC
GO

Mass spectrometryi

Molecular mass is 58025±3 Da from positions 2 - 530. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720580 mRNA. Translation: CAG32239.1.
RefSeqiNP_001006216.1. NM_001006216.1.
UniGeneiGga.1225.

Genome annotation databases

GeneIDi417541.
KEGGigga:417541.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720580 mRNA. Translation: CAG32239.1.
RefSeqiNP_001006216.1. NM_001006216.1.
UniGeneiGga.1225.

3D structure databases

ProteinModelPortaliQ5ZJ54.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi678874. 1 interaction.
STRINGi9031.ENSGALP00000003850.

Proteomic databases

PaxDbiQ5ZJ54.
PRIDEiQ5ZJ54.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi417541.
KEGGigga:417541.

Organism-specific databases

CTDi908.

Phylogenomic databases

eggNOGiKOG0359. Eukaryota.
ENOG410XQ3Q. LUCA.
HOGENOMiHOG000226733.
HOVERGENiHBG103725.
InParanoidiQ5ZJ54.
KOiK09498.
OMAiEPMKPVD.
OrthoDBiEOG091G07CE.
PhylomeDBiQ5ZJ54.

Enzyme and pathway databases

ReactomeiR-GGA-390471. Association of TriC/CCT with target proteins during biosynthesis.
R-GGA-6814122. Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding.

Miscellaneous databases

PROiQ5ZJ54.

Gene expression databases

BgeeiENSGALG00000002448.
ExpressionAtlasiQ5ZJ54. baseline.

Family and domain databases

Gene3Di1.10.560.10. 2 hits.
3.30.260.10. 2 hits.
3.50.7.10. 1 hit.
InterProiIPR012722. Chap_CCT_zeta.
IPR017998. Chaperone_TCP-1.
IPR002194. Chaperonin_TCP-1_CS.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
[Graphical view]
PfamiPF00118. Cpn60_TCP1. 1 hit.
[Graphical view]
PRINTSiPR00304. TCOMPLEXTCP1.
SUPFAMiSSF52029. SSF52029. 1 hit.
TIGRFAMsiTIGR02347. chap_CCT_zeta. 1 hit.
PROSITEiPS00750. TCP1_1. 1 hit.
PS00751. TCP1_2. 1 hit.
PS00995. TCP1_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTCPZ_CHICK
AccessioniPrimary (citable) accession number: Q5ZJ54
Secondary accession number(s): P84164
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.