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Protein

T-complex protein 1 subunit zeta

Gene

CCT6

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-GGA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit zeta
Short name:
TCP-1-zeta
Alternative name(s):
CCT-zeta
Gene namesi
Name:CCT6By similarity
ORF Names:RCJMB04_20k5
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002234832 – 530T-complex protein 1 subunit zetaAdd BLAST529

Proteomic databases

PaxDbiQ5ZJ54
PRIDEiQ5ZJ54

Expressioni

Gene expression databases

BgeeiENSGALG00000002448
ExpressionAtlasiQ5ZJ54 baseline and differential

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi678874, 1 interactor
STRINGi9031.ENSGALP00000003850

Structurei

3D structure databases

ProteinModelPortaliQ5ZJ54
SMRiQ5ZJ54
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Sequence analysis

Phylogenomic databases

eggNOGiKOG0359 Eukaryota
ENOG410XQ3Q LUCA
GeneTreeiENSGT00550000074743
HOGENOMiHOG000226733
HOVERGENiHBG103725
InParanoidiQ5ZJ54
KOiK09498
OMAiMQHKTDT
OrthoDBiEOG091G07CE
PhylomeDBiQ5ZJ54

Family and domain databases

CDDicd03342 TCP1_zeta, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012722 Chap_CCT_zeta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02347 chap_CCT_zeta, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ZJ54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVKALNPKA EVARAQAALA VNISAARGLQ DVLRTNLGPK GTMKMLVSGA
60 70 80 90 100
GDIKLTKDGN VLLQEMQIQH PTASLIAKVA TAQDDITGDG TTSNVLIIGE
110 120 130 140 150
LLKQADLYIS EGLHPRIVAE GFEIAKEKAL EVLEQVKVTK EMDRETLIDV
160 170 180 190 200
AKTSLRTKVH TELADILTEA VVDSVLAVRK PGEPIDLHMV EIMEMKHKSE
210 220 230 240 250
TDTTLIRGLV LDHGARHPDM KKRVEDAYIL TCNVSLEYEK TEVSAGFFYK
260 270 280 290 300
SAEEREKLVK AERKFIEDRV SKIIDLKRRV CGDSDKGFIV INQKGIDPFS
310 320 330 340 350
LDALAKEGIV ALRRAKRRNM ERLTLACGGT AMNSVEDLTP DCLGHAGLVY
360 370 380 390 400
EYTLGEEKYT FIEKCDNPRS VTLLIRGPNK HTLTQIKDAV RDGLRAVKNA
410 420 430 440 450
IEDGCVIPGA GALEVAVANA LVKHKPNVKG RAQLGVQAFA DALLIIPKVL
460 470 480 490 500
AQNSGYDPQE TLVKVQAEHA ESGQLTGVDL NTGEPMVAAA AGIWDNYNVK
510 520 530
KQLLHSCTVI ASNILLVDEI MRAGMSSLKG
Length:530
Mass (Da):57,645
Last modified:January 23, 2007 - v3
Checksum:i8B8F639A186F12EC
GO

Mass spectrometryi

Molecular mass is 58025±3 Da from positions 2 - 530. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720580 mRNA Translation: CAG32239.1
RefSeqiNP_001006216.1, NM_001006216.1
UniGeneiGga.1225

Genome annotation databases

EnsembliENSGALT00000003859; ENSGALP00000003850; ENSGALG00000002448
GeneIDi417541
KEGGigga:417541

Similar proteinsi

Entry informationi

Entry nameiTCPZ_CHICK
AccessioniPrimary (citable) accession number: Q5ZJ54
Secondary accession number(s): P84164
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 100 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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