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Q5ZJ23

- ASSY_CHICK

UniProt

Q5ZJ23 - ASSY_CHICK

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Protein
Argininosuccinate synthase
Gene
ASS1, RCJMB04_21j5
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei88 – 881Citrulline By similarity
Binding sitei120 – 1201Aspartate By similarity
Binding sitei124 – 1241Aspartate By similarity
Binding sitei124 – 1241Citrulline By similarity
Binding sitei125 – 1251Aspartate By similarity
Binding sitei128 – 1281Citrulline By similarity
Binding sitei181 – 1811Citrulline By similarity
Binding sitei190 – 1901Citrulline By similarity
Binding sitei271 – 2711Citrulline By similarity
Binding sitei283 – 2831Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi11 – 199ATP By similarity
Nucleotide bindingi116 – 1249ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. argininosuccinate synthase activity Source: AgBase

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-UniPathway
  2. urea cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis, Urea cycle

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00068; UER00113.
UPA00158; UER00272.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:ASS1
ORF Names:RCJMB04_21j5
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Argininosuccinate synthaseUniRule annotation
PRO_0000321322Add
BLAST

Proteomic databases

PaxDbiQ5ZJ23.

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006379.

Structurei

3D structure databases

ProteinModelPortaliQ5ZJ23.
SMRiQ5ZJ23. Positions 5-408.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
HOVERGENiHBG001717.
InParanoidiQ5ZJ23.
KOiK01940.
PhylomeDBiQ5ZJ23.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZJ23-1 [UniParc]FASTAAdd to Basket

« Hide

MAEPRDTVVL AYSGGLDTSC ILVWLKEQGY TVIAFLANIG QTEDFDAAQK    50
KALALGAKKV YIQDVCREFV EDFIWPAVRA NALYEDRYML GSALARPCIA 100
RHLVLIAQEE GARYIAHGAT GKGNDQVRFE LGCYALCPSI KVIAPWRMPE 150
FYQRFPGRRE LMEYAQKHGI PVPVTPKAPW SMDENLMHIS YEAGILENPK 200
NRAPLDLYTK TCNPTTSPDV PDELEIEFEK GVPVKVTNTR NGVTHRSALE 250
LFVYLNDIAS KHGVGRVDIV ENRFVGMKSR GIYETPAGTI LYHAHLDIEA 300
FTMDREVRKI KQGLSLKFSE LVYNGFWYSP ECEFLKHCIA RSQQAVAGTV 350
HVSVFKGQVY VLGRESPHSL YNEELVSMDV QGDYEPADAT GFININALRL 400
KEYHRLQSKV STKQDE 416
Length:416
Mass (Da):46,904
Last modified:November 23, 2004 - v1
Checksum:iAF0CC73CA67D1B71
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ720611 mRNA. Translation: CAG32270.1.
RefSeqiNP_001013413.1. NM_001013395.1.
UniGeneiGga.5385.

Genome annotation databases

GeneIDi417185.
KEGGigga:417185.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ720611 mRNA. Translation: CAG32270.1 .
RefSeqi NP_001013413.1. NM_001013395.1.
UniGenei Gga.5385.

3D structure databases

ProteinModelPortali Q5ZJ23.
SMRi Q5ZJ23. Positions 5-408.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000006379.

Proteomic databases

PaxDbi Q5ZJ23.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 417185.
KEGGi gga:417185.

Organism-specific databases

CTDi 445.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
HOVERGENi HBG001717.
InParanoidi Q5ZJ23.
KOi K01940.
PhylomeDBi Q5ZJ23.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
UPA00158 ; UER00272 .

Miscellaneous databases

NextBioi 20820530.
PROi Q5ZJ23.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiASSY_CHICK
AccessioniPrimary (citable) accession number: Q5ZJ23
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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