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Q5ZJ23

- ASSY_CHICK

UniProt

Q5ZJ23 - ASSY_CHICK

Protein

Argininosuccinate synthase

Gene

ASS1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei37 – 371ATP; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei88 – 881CitrullineBy similarity
    Binding sitei120 – 1201AspartateBy similarity
    Binding sitei124 – 1241AspartateBy similarity
    Binding sitei124 – 1241CitrullineBy similarity
    Binding sitei125 – 1251AspartateBy similarity
    Binding sitei128 – 1281CitrullineBy similarity
    Binding sitei181 – 1811CitrullineBy similarity
    Binding sitei190 – 1901CitrullineBy similarity
    Binding sitei271 – 2711CitrullineBy similarity
    Binding sitei283 – 2831CitrullineBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 199ATPBy similarity
    Nucleotide bindingi116 – 1249ATPBy similarity

    GO - Molecular functioni

    1. argininosuccinate synthase activity Source: AgBase
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. arginine biosynthetic process Source: UniProtKB-UniPathway
    2. urea cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Amino-acid biosynthesis, Arginine biosynthesis, Urea cycle

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00068; UER00113.
    UPA00158; UER00272.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Argininosuccinate synthase (EC:6.3.4.5)
    Alternative name(s):
    Citrulline--aspartate ligase
    Gene namesi
    Name:ASS1
    ORF Names:RCJMB04_21j5
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 416416Argininosuccinate synthasePRO_0000321322Add
    BLAST

    Proteomic databases

    PaxDbiQ5ZJ23.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000006379.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5ZJ23.
    SMRiQ5ZJ23. Positions 5-408.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the argininosuccinate synthase family.Curated

    Phylogenomic databases

    eggNOGiCOG0137.
    HOGENOMiHOG000230093.
    HOVERGENiHBG001717.
    InParanoidiQ5ZJ23.
    KOiK01940.
    PhylomeDBiQ5ZJ23.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPiMF_00005. Arg_succ_synth_type1.
    InterProiIPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF00764. Arginosuc_synth. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00032. argG. 1 hit.
    PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5ZJ23-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEPRDTVVL AYSGGLDTSC ILVWLKEQGY TVIAFLANIG QTEDFDAAQK    50
    KALALGAKKV YIQDVCREFV EDFIWPAVRA NALYEDRYML GSALARPCIA 100
    RHLVLIAQEE GARYIAHGAT GKGNDQVRFE LGCYALCPSI KVIAPWRMPE 150
    FYQRFPGRRE LMEYAQKHGI PVPVTPKAPW SMDENLMHIS YEAGILENPK 200
    NRAPLDLYTK TCNPTTSPDV PDELEIEFEK GVPVKVTNTR NGVTHRSALE 250
    LFVYLNDIAS KHGVGRVDIV ENRFVGMKSR GIYETPAGTI LYHAHLDIEA 300
    FTMDREVRKI KQGLSLKFSE LVYNGFWYSP ECEFLKHCIA RSQQAVAGTV 350
    HVSVFKGQVY VLGRESPHSL YNEELVSMDV QGDYEPADAT GFININALRL 400
    KEYHRLQSKV STKQDE 416
    Length:416
    Mass (Da):46,904
    Last modified:November 23, 2004 - v1
    Checksum:iAF0CC73CA67D1B71
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ720611 mRNA. Translation: CAG32270.1.
    RefSeqiNP_001013413.1. NM_001013395.1.
    UniGeneiGga.5385.

    Genome annotation databases

    GeneIDi417185.
    KEGGigga:417185.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ720611 mRNA. Translation: CAG32270.1 .
    RefSeqi NP_001013413.1. NM_001013395.1.
    UniGenei Gga.5385.

    3D structure databases

    ProteinModelPortali Q5ZJ23.
    SMRi Q5ZJ23. Positions 5-408.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000006379.

    Proteomic databases

    PaxDbi Q5ZJ23.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 417185.
    KEGGi gga:417185.

    Organism-specific databases

    CTDi 445.

    Phylogenomic databases

    eggNOGi COG0137.
    HOGENOMi HOG000230093.
    HOVERGENi HBG001717.
    InParanoidi Q5ZJ23.
    KOi K01940.
    PhylomeDBi Q5ZJ23.

    Enzyme and pathway databases

    UniPathwayi UPA00068 ; UER00113 .
    UPA00158 ; UER00272 .

    Miscellaneous databases

    NextBioi 20820530.
    PROi Q5ZJ23.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    3.90.1260.10. 1 hit.
    HAMAPi MF_00005. Arg_succ_synth_type1.
    InterProi IPR001518. Arginosuc_synth.
    IPR018223. Arginosuc_synth_CS.
    IPR023434. Arginosuc_synth_type_1_subfam.
    IPR024074. AS_cat/multimer_dom_body.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF00764. Arginosuc_synth. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00032. argG. 1 hit.
    PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
    PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: CB.
      Tissue: Bursa of Fabricius.

    Entry informationi

    Entry nameiASSY_CHICK
    AccessioniPrimary (citable) accession number: Q5ZJ23
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3