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Q5ZIZ0 (Q5ZIZ0_CHICK) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating RuleBase RU000485 PIRNR PIRNR000109
EC=1.1.1.44 RuleBase RU000485 PIRNR PIRNR000109
Gene names
Name:Gga.1282 Ensembl ENSGALP00000004417
ORF Names:RCJMB04_22k15 EMBL CAG32303.1
OrganismGallus gallus (Chicken) EMBL CAG32303.1
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length483 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. RuleBase RU000485 PIRNR PIRNR000109

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. RuleBase RU004281 PIRNR PIRNR000109

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. RuleBase RU000485 PIRNR PIRNR000109

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding10 – 156NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding33 – 353NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000109-3
Region129 – 1313Substrate binding By similarity PIRSR PIRSR000109-2
Region187 – 1882Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1841Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1911Proton donor By similarity PIRSR PIRSR000109-1
Binding site1031NADP By similarity PIRSR PIRSR000109-3
Binding site1031Substrate By similarity PIRSR PIRSR000109-2
Binding site1921Substrate By similarity PIRSR PIRSR000109-2
Binding site2611Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2881Substrate By similarity PIRSR PIRSR000109-2
Binding site4471Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4531Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
Q5ZIZ0 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: B60D54E9AF67FF98

FASTA48353,292
        10         20         30         40         50         60 
MAEADIALIG LAVMGQNLIL NMNDHGFVVC AFNRTVSKVD DFLANEAKGT KVIGAHSLEE 

        70         80         90        100        110        120 
MVSKLKKPRR IILLVKAGSA VDDFINKLVP LLETGDIIID GGNSEYRDTT RRCKELLQKG 

       130        140        150        160        170        180 
LLFVGSGVSG GEEGARYGPS LMPGGSKEAW PHIKTIFQSI AAKVGSGEPC CDWVGEEGAG 

       190        200        210        220        230        240 
HFVKMVHNGI EYGDMQLICE AYHLMKDVVG MDHDEMSQVF EEWNNTELDS FLIEITANIL 

       250        260        270        280        290        300 
KFKDKDGKYL LPKIRDSAGQ KGTGKWTAIS ALEYGVPVTL IGEAVFARCL SSLKDERVQA 

       310        320        330        340        350        360 
SKLLNGPKLT QFSGNKKAFL EDIRKALYAS KIISYAQGFM LLRQAAKEFG WTLNYGGIAL 

       370        380        390        400        410        420 
MWRGGCIIRS VFLGKIKDAF DRNPELQNLL LDDFFKTAVE KCQDSWRHVI STGVQHGIPM 

       430        440        450        460        470        480 
PCFTTALSFY DGYRHEVLPA NLIQAQRDYF GAHTYELLSK PGVFIHTNWT GHGGNVSSSA 


YNV

« Hide

References

« Hide 'large scale' references
[1]"Full-length cDNAs from chicken bursal lymphocytes to facilitate genefunction analysis."
Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.M.
Genome Biol. 6:R6-R6(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: CB EMBL CAG32303.1.
Tissue: Bursa EMBL CAG32303.1.
[2]"Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
International Chicken Genome Sequencing Consortium
Hillier L.W., Miller W., Birney E., Warren W., Hardison R.C., Ponting C.P., Bork P., Burt D.W., Groenen M.A.M., Delany M.E., Dodgson J.B., Chinwalla A.T., Cliften P.F., Clifton S.W., Delehaunty K.D., Fronick C., Fulton R.S., Graves T.A. expand/collapse author list , Kremitzki C., Layman D., Magrini V., McPherson J.D., Miner T.L., Minx P., Nash W.E., Nhan M.N., Nelson J.O., Oddy L.G., Pohl C.S., Randall-Maher J., Smith S.M., Wallis J.W., Yang S.-P., Romanov M.N., Rondelli C.M., Paton B., Smith J., Morrice D., Daniels L., Tempest H.G., Robertson L., Masabanda J.S., Griffin D.K., Vignal A., Fillon V., Jacobbson L., Kerje S., Andersson L., Crooijmans R.P., Aerts J., van der Poel J.J., Ellegren H., Caldwell R.B., Hubbard S.J., Grafham D.V., Kierzek A.M., McLaren S.R., Overton I.M., Arakawa H., Beattie K.J., Bezzubov Y., Boardman P.E., Bonfield J.K., Croning M.D.R., Davies R.M., Francis M.D., Humphray S.J., Scott C.E., Taylor R.G., Tickle C., Brown W.R.A., Rogers J., Buerstedde J.-M., Wilson S.A., Stubbs L., Ovcharenko I., Gordon L., Lucas S., Miller M.M., Inoko H., Shiina T., Kaufman J., Salomonsen J., Skjoedt K., Wong G.K.-S., Wang J., Liu B., Wang J., Yu J., Yang H., Nefedov M., Koriabine M., Dejong P.J., Goodstadt L., Webber C., Dickens N.J., Letunic I., Suyama M., Torrents D., von Mering C., Zdobnov E.M., Makova K., Nekrutenko A., Elnitski L., Eswara P., King D.C., Yang S., Tyekucheva S., Radakrishnan A., Harris R.S., Chiaromonte F., Taylor J., He J., Rijnkels M., Griffiths-Jones S., Ureta-Vidal A., Hoffman M.M., Severin J., Searle S.M.J., Law A.S., Speed D., Waddington D., Cheng Z., Tuzun E., Eichler E., Bao Z., Flicek P., Shteynberg D.D., Brent M.R., Bye J.M., Huckle E.J., Chatterji S., Dewey C., Pachter L., Kouranov A., Mourelatos Z., Hatzigeorgiou A.G., Paterson A.H., Ivarie R., Brandstrom M., Axelsson E., Backstrom N., Berlin S., Webster M.T., Pourquie O., Reymond A., Ucla C., Antonarakis S.E., Long M., Emerson J.J., Betran E., Dupanloup I., Kaessmann H., Hinrichs A.S., Bejerano G., Furey T.S., Harte R.A., Raney B., Siepel A., Kent W.J., Haussler D., Eyras E., Castelo R., Abril J.F., Castellano S., Camara F., Parra G., Guigo R., Bourque G., Tesler G., Pevzner P.A., Smit A., Fulton L.A., Mardis E.R., Wilson R.K.
Nature 432:695-716(2004) [PubMed: 15592404] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Red jungle fowl Ensembl ENSGALP00000004417.
[3]Ensembl
Submitted (JUL-2011) to UniProtKB
Cited for: IDENTIFICATION.
Strain: Red jungle fowl Ensembl ENSGALP00000004417.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AADN02040782 Genomic DNA. No translation available.
AADN02040783 Genomic DNA. No translation available.
AJ720644 mRNA. Translation: CAG32303.1.
IPIIPI00570964.
RefSeqNP_001006303.1. NM_001006303.1.
UniGeneGga.1282.

3D structure databases

ProteinModelPortalQ5ZIZ0.
SMRQ5ZIZ0. Positions 2-474.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ5ZIZ0.

Proteomic databases

PRIDEQ5ZIZ0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000004426; ENSGALP00000004417; ENSGALG00000002797.
GeneID419450.
KEGGgga:419450.

Organism-specific databases

CTD5226.

Phylogenomic databases

eggNOGveNOG04483.
GeneTreeENSGT00390000009023.
HOGENOMHBG286913.
HOVERGENHBG000029.
InParanoidQ5ZIZ0.
OMAMEHNEMA.
OrthoDBEOG4C2H9D.
PhylomeDBQ5ZIZ0.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ5ZIZ0_CHICK
AccessionPrimary (citable) accession number: Q5ZIZ0
Entry history
Integrated into UniProtKB/TrEMBL: November 23, 2004
Last sequence update: November 23, 2004
Last modified: December 14, 2011
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info