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Protein

Lysine-specific demethylase 3A

Gene

KDM3A

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate (By similarity).By similarity

Cofactori

Fe2+By similarityNote: Binds 1 Fe2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi1124 – 11241Iron; catalyticPROSITE-ProRule annotation
Metal bindingi1126 – 11261Iron; catalyticPROSITE-ProRule annotation
Metal bindingi1253 – 12531Iron; catalyticPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri669 – 69426C6-typeSequence analysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Dioxygenase, Oxidoreductase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Iron, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine-specific demethylase 3A (EC:1.14.11.-)
Alternative name(s):
JmjC domain-containing histone demethylation protein 2A
Jumonji domain-containing protein 1A
Gene namesi
Name:KDM3A
Synonyms:JHDM2A, JMJD1A
ORF Names:RCJMB04_22o22
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13251325Lysine-specific demethylase 3APRO_0000234370Add
BLAST

Proteomic databases

PaxDbiQ5ZIX8.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000025436.

Structurei

3D structure databases

ProteinModelPortaliQ5ZIX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1062 – 1285224JmjCPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi888 – 8925LXXLL motif

Domaini

The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.By similarity
Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors.By similarity

Sequence similaritiesi

Belongs to the JHDM2 histone demethylase family.Curated
Contains 1 JmjC domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri669 – 69426C6-typeSequence analysisAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1356. Eukaryota.
ENOG410XTAA. LUCA.
HOGENOMiHOG000007471.
InParanoidiQ5ZIX8.
KOiK15601.
PhylomeDBiQ5ZIX8.

Family and domain databases

InterProiIPR003347. JmjC_dom.
[Graphical view]
PfamiPF02373. JmjC. 1 hit.
[Graphical view]
SMARTiSM00558. JmjC. 1 hit.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZIX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLRLEGSWS LLVGKRFLSL SGDDDGPWDT ERVAEWPWQA GRIRAVSHTD
60 70 80 90 100
ISKPDLKICV EFDDESWEKR RWIEVYSPKM KVFLVEQKLV LAERRSHGGS
110 120 130 140 150
ISPVQWPAMT YKSLVDKAGL GPMVSIRYLG EEKCVFLSKD LLTPIQDVES
160 170 180 190 200
SRLPLKDDQT VNEEIQALVK KHLDETRLVQ GGKNIIGSKI RIYSLDPSTQ
210 220 230 240 250
WFTAVVVNGN PATRTLEVNC QEIPALKTLD PELIHVEIIY DNNGKCDKSK
260 270 280 290 300
RIGGVKRKPS ENSGSVDAKH TKSSPEVSQS QGHVHSVPTV FGEALLGCTP
310 320 330 340 350
ANKDQRHQGL PLPANSPPNL GAETPQGTCR RSVPEVHPSC LNAGTKPLKE
360 370 380 390 400
NLTLFPKVTY ITKEQTQNIN DQNGKYTSLI SSRSSSLSDS TNGKETGLKN
410 420 430 440 450
ISEPLLKPTT NFPKECISAK PLQHLNSSIA IPRVNSSVEL QRTLDCRPST
460 470 480 490 500
SDAHLLPFTE AGVRSHSGSN SQKGNKVDEH VEMEFFTRRN SNEAFYERNE
510 520 530 540 550
NESFWTGSTK IQDNVIVRKS ILADASKVKK LQQSGEAFVQ DGSCNNIAPH
560 570 580 590 600
LHKCRECRLD SYRKNKDQKD STVFCRFFHF RRLQFNKHGI LREEGFLTPN
610 620 630 640 650
KYDPEAISLW LPLSKNVVGL DLDTAKYILA NIGDHFCQLV ISEKEVMSTI
660 670 680 690 700
EPHRQVAWKR AVRGVREMCD VCDTTIFNLR WVCSKCGFGV CVDCYRMRKK
710 720 730 740 750
GIHEDDDSDT FSWFKCVKGQ EHEPENLMPT QIIPGRALYD VGDIVHSVRT
760 770 780 790 800
KWGIKANCPC ANKQFKALSK PTLKEDSKQN LVPGERTSLQ QSNLVLSPQL
810 820 830 840 850
PTHEPPVKPA AGSKQTASVT TSPSLSWLSN ITSGNVNKEN KEKLLVPISK
860 870 880 890 900
NENKALQTLP SLAKPAAALQ TFNSAILTPV SNNNTGFLRN LLNSSGGKTD
910 920 930 940 950
NGLKSTPKIL DDIFASLVQN RTVTDMPKKP QGLTIKPTIM GFDTPHYWLC
960 970 980 990 1000
DNRLLCLQDP NNESNWNVFR ECWKQGQPVM VSGVHHKLNA DLWRPESFRK
1010 1020 1030 1040 1050
EFGQQEVDLV NCRTNEIITG ATVGDFWDGF EDISSRLRTE EGEPMVLKLK
1060 1070 1080 1090 1100
DWPPGEDFRD MMPSRFDDLM KNIPLPEYTR RGGKLNLASR LPNYFVRPDL
1110 1120 1130 1140 1150
GPKMYNAYGL ITPEDRKYGT TNLHLDVSDA ANVMVYVGIP KGQADQEEEV
1160 1170 1180 1190 1200
LKTIQDGDSD ELTIKRFTES REKPGALWHI YAAKDTEKIR EFLKKVAEEQ
1210 1220 1230 1240 1250
GQENPVDHDP IHDQSWYLDR SLRKRLHQEY GVQGWAIVQF LGDVVFIPAG
1260 1270 1280 1290 1300
APHQVHNLYS CIKVAEDFVS PEHVKHCFWL TQEFRYLSHT HTNHEDKLQV
1310 1320
KNVIYHAVKD AVGILRANES SLSRS
Length:1,325
Mass (Da):149,333
Last modified:November 23, 2004 - v1
Checksum:i9F4699CEE1960776
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720656 mRNA. Translation: CAG32315.1.
RefSeqiNP_001012909.1. NM_001012891.1.
UniGeneiGga.17648.

Genome annotation databases

GeneIDi422917.
KEGGigga:422917.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720656 mRNA. Translation: CAG32315.1.
RefSeqiNP_001012909.1. NM_001012891.1.
UniGeneiGga.17648.

3D structure databases

ProteinModelPortaliQ5ZIX8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000025436.

Proteomic databases

PaxDbiQ5ZIX8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi422917.
KEGGigga:422917.

Organism-specific databases

CTDi55818.

Phylogenomic databases

eggNOGiKOG1356. Eukaryota.
ENOG410XTAA. LUCA.
HOGENOMiHOG000007471.
InParanoidiQ5ZIX8.
KOiK15601.
PhylomeDBiQ5ZIX8.

Miscellaneous databases

NextBioi20825473.
PROiQ5ZIX8.

Family and domain databases

InterProiIPR003347. JmjC_dom.
[Graphical view]
PfamiPF02373. JmjC. 1 hit.
[Graphical view]
SMARTiSM00558. JmjC. 1 hit.
[Graphical view]
PROSITEiPS51184. JMJC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiKDM3A_CHICK
AccessioniPrimary (citable) accession number: Q5ZIX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: November 23, 2004
Last modified: May 11, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.