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Q5ZIV9 (ADSV_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adseverin
Alternative name(s):
Scinderin
Gene names
Name:SCIN
ORF Names:RCJMB04_23d8
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length717 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Ca2+-dependent actin filament-severing protein that is presumed to have a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca2+. Regulates chondrocyte proliferation and differentiation. MAP kinases p38 and ERK1/2 mediate the adseverin-induced accelerated differentiation of non-hypertrophic chondrocytes. Ref.1

Subcellular location

Cytoplasm › cytoskeleton By similarity.

Developmental stage

Expressed in the pre-hypertrophic and hypertrophic cartilage of the embryonic growth plate. Ref.1

Induction

Up-regulated in pre-hypertrophic and hypertrophic chondrocytes during the embryonic development of long bones. Ref.1

Sequence similarities

Belongs to the villin/gelsolin family.

Contains 6 gelsolin-like repeats.

Sequence caution

The sequence CAG32334.1 differs from that shown. Reason: Erroneous termination at position 224. Translated as Leu.

The sequence CAG32334.1 differs from that shown. Reason: Frameshift at positions 196 and 212.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 717717Adseverin
PRO_0000404255

Regions

Repeat28 – 10881Gelsolin-like 1
Repeat148 – 22073Gelsolin-like 2
Repeat265 – 34076Gelsolin-like 3
Repeat408 – 48376Gelsolin-like 4
Repeat526 – 59065Gelsolin-like 5
Repeat628 – 70376Gelsolin-like 6
Region1 – 363363Actin-severing By similarity
Region112 – 1198Polyphosphoinositide binding By similarity
Region138 – 1469Polyphosphoinositide binding By similarity
Region364 – 715352Ca(2+)-dependent actin binding By similarity
Compositional bias235 – 2384Poly-Asp

Experimental info

Sequence conflict961S → R in DQ020143. Ref.1
Sequence conflict2121E → K in CAG32334. Ref.2
Sequence conflict2201L → V in CAG32334. Ref.2
Sequence conflict253 – 2542MV → KA in DQ020143. Ref.1
Sequence conflict5361N → D in DQ020143. Ref.1
Sequence conflict6861D → V in DQ020143. Ref.1
Sequence conflict7131N → T in DQ020143. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q5ZIV9 [UniParc].

Last modified February 8, 2011. Version 2.
Checksum: 1447FE1421E19AE7

FASTA71780,533
        10         20         30         40         50         60 
MAPERHPPAF EGAGQESGLQ VWRVERLELV PVPPSRHGDF FVGDAYLVLH TVRRGAAVAY 

        70         80         90        100        110        120 
RLHYWLGKEC TQDESTAAAI FTVQLDDYLG GKPVQSREIQ GYESNEFVSY FKGGIKYKAG 

       130        140        150        160        170        180 
GVASGFNHVV TNDLSAQRLL HIKGRRVVRA TEVPLTWASF NKGDCFIIDL GNEIYQWCGS 

       190        200        210        220        230        240 
SCNKYERLKA TQVAVGIRDN ERNGRSRLIT VEEGSEPDEL ITVLGEKPEL PECSDDDDEM 

       250        260        270        280        290        300 
ADIANRKSAK LYMVSDASGS MKLSVVAEEN PFSMAMLLSE ECFILDNGAA RKIFVWKGKD 

       310        320        330        340        350        360 
ANPQERKAAM KNAETFVQQM NYPANTQIQV LPEGGETPIF KQFFKDWKDK DQSDGFGKVY 

       370        380        390        400        410        420 
VTERVAKIEQ IEFDATKLHE SPQMAAQHNM IDDGSGKVQI WRVESSGRVP VEPETYGQFY 

       430        440        450        460        470        480 
GGDCYIILYT YPKGQIIYTW QGACATKDEL TASAFLTVQL DRSLNDQAVQ IRVSQGKEPP 

       490        500        510        520        530        540 
HLLSLFKNKP LIVYKNGTSK KEGQKPAPPT RLFQIRRNLM SVTRIAEVDV DAMSLNSNDA 

       550        560        570        580        590        600 
FVLKLPNNTG YTWVGKGVNK EEEQGAQYIA SVLKCQTAKI NEGQEPEEFW KALGGKKKYQ 

       610        620        630        640        650        660 
TSSQLLTKAE DHPPRLFGCS NKTGRFIIEE VPGEFTQDDL AEDDVMLLDA WEQVFVWIGK 

       670        680        690        700        710 
EANETERQES VKSAKRYIET DPSGRDKGTP IVIVKQGHEP PTFTGWFLAW DSNKWKN

« Hide

References

« Hide 'large scale' references
[1]"Regulation of chondrocyte differentiation by actin-severing protein adseverin."
Nurminsky D., Magee C., Faverman L., Nurminskaya M.
Dev. Biol. 302:427-437(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, INDUCTION.
[2]"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis."
Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.
Genome Biol. 6:R6.1-R6.9(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: CB.
Tissue: Bursa of Fabricius.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		DQ020143 mRNA. No translation available.
AJ720675 mRNA. Translation: CAG32334.1. Sequence problems.
IPIIPI00812776.
RefSeqNP_001231522.1. NM_001244593.1.
UniGeneGga.17090.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000037173.

Proteomic databases

PaxDbQ5ZIV9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID420588.
KEGGgga:420588.

Organism-specific databases

CTD85477.

Phylogenomic databases

eggNOGNOG304849.
HOGENOMHOG000176098.
HOVERGENHBG059781.
KOK05768.

Gene expression databases

ArrayExpressQ5ZIV9.

Family and domain databases

InterProIPR007123. Gelsolin_dom.
IPR007122. Villin/Gelsolin.
[Graphical view]
PANTHERPTHR11977. PTHR11977. 1 hit.
PfamPF00626. Gelsolin. 6 hits.
[Graphical view]
PRINTSPR00597. GELSOLIN.
SMARTSM00262. GEL. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20823479.

Entry information

Entry nameADSV_CHICK
AccessionPrimary (citable) accession number: Q5ZIV9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: February 8, 2011
Last modified: May 1, 2013
This is version 47 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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