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Q5ZIV1

- MTMR2_CHICK

UniProt

Q5ZIV1 - MTMR2_CHICK

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Protein
Myotubularin-related protein 2
Gene
MTMR2, RCJMB04_23g22
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei345 – 3451Phosphocysteine intermediate By similarity
Binding sitei391 – 3911Substrate By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    ReactomeiREACT_198199. Synthesis of PIPs at the early endosome membrane.
    REACT_198210. Synthesis of PIPs at the late endosome membrane.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myotubularin-related protein 2 (EC:3.1.3.-)
    Gene namesi
    Name:MTMR2
    ORF Names:RCJMB04_23g22
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 1

    Subcellular locationi

    Cytoplasm. Membrane; Peripheral membrane protein
    Note: Partly associated with membranes By similarity.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 571571Myotubularin-related protein 2
    PRO_0000356229Add
    BLAST

    Proteomic databases

    PaxDbiQ5ZIV1.

    Interactioni

    Subunit structurei

    Homooligomer and heterooligomer By similarity.

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000027747.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5ZIV1.
    SMRiQ5ZIV1. Positions 1-514.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 6767GRAM
    Add
    BLAST
    Domaini133 – 508376Myotubularin phosphatase
    Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni258 – 2614Substrate binding By similarity
    Regioni283 – 2842Substrate binding By similarity
    Regioni345 – 3517Substrate binding By similarity

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili521 – 55333 Reviewed prediction
    Add
    BLAST

    Sequence similaritiesi

    Contains 1 GRAM domain.

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG322789.
    GeneTreeiENSGT00670000097670.
    HOGENOMiHOG000210598.
    HOVERGENiHBG000220.
    InParanoidiQ5ZIV1.
    KOiK18081.
    OMAiPENGWKV.
    OrthoDBiEOG7XDBF9.
    PhylomeDBiQ5ZIV1.
    TreeFamiTF315197.

    Family and domain databases

    Gene3Di2.30.29.30. 1 hit.
    InterProiIPR004182. GRAM.
    IPR010569. Myotubularin-like_Pase_dom.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PfamiPF02893. GRAM. 1 hit.
    PF06602. Myotub-related. 1 hit.
    [Graphical view]
    SMARTiSM00568. GRAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5ZIV1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEPPLLPGE TIKDMAKDVT YICPFTGAIR GTLTVTNYRL YFKSMERDPP    50
    FVLDASLGVI NRVEKIGGAS SRGENSYGLE IVCKDIRNLR FAHKPEGRTR 100
    RSIFENLMKY AFPVSNNLPL FAFEYKEVFP ENGWKVYDPI WEYRRQGIPN 150
    ESWRLSKINE HYELCDTYPA ILAVPVNIPD EELKRVASFR SRGRIPVLSW 200
    IHPESQATIT RCSQPMVGVS GKRSKEDEKY LQAIMDSNAQ SHKIFIFDAR 250
    PSVNAVANKA KGGGYESEDA YQNAELVFLD IHNIHVMRES LRKLKEIVYP 300
    NIEETHWLSN LESTHWLEHI KLILAGALRI ADKVESGKTS VVVHCSDGWD 350
    RTAQLTSLSL LMLDGYYRTI RGFEVLVEKE WLSFGHRFQL RVGHGDKNHA 400
    DADRSPVFLQ FIDCVWQMTR QFPTAFEFNE YFLITILDHL YSCLFGTFLC 450
    SSEQQRVKES LPKKTVSLWS YINSQLEDFT NPLYVSYSNH VLYPVASMRH 500
    LELWVGYYIR WNPRMKPQEP VHNRYKELLA KRAELQKKVE ELQREITNRS 550
    TSSSERAGSP AQCVTPVQTV V 571
    Length:571
    Mass (Da):65,968
    Last modified:November 23, 2004 - v1
    Checksum:i6C984994DCB04B27
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ720683 mRNA. Translation: CAG32342.1.
    RefSeqiNP_001034363.1. NM_001039274.1.
    UniGeneiGga.2647.

    Genome annotation databases

    EnsembliENSGALT00000027800; ENSGALP00000027747; ENSGALG00000017200.
    GeneIDi418992.
    KEGGigga:418992.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ720683 mRNA. Translation: CAG32342.1 .
    RefSeqi NP_001034363.1. NM_001039274.1.
    UniGenei Gga.2647.

    3D structure databases

    ProteinModelPortali Q5ZIV1.
    SMRi Q5ZIV1. Positions 1-514.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000027747.

    Proteomic databases

    PaxDbi Q5ZIV1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000027800 ; ENSGALP00000027747 ; ENSGALG00000017200 .
    GeneIDi 418992.
    KEGGi gga:418992.

    Organism-specific databases

    CTDi 8898.

    Phylogenomic databases

    eggNOGi NOG322789.
    GeneTreei ENSGT00670000097670.
    HOGENOMi HOG000210598.
    HOVERGENi HBG000220.
    InParanoidi Q5ZIV1.
    KOi K18081.
    OMAi PENGWKV.
    OrthoDBi EOG7XDBF9.
    PhylomeDBi Q5ZIV1.
    TreeFami TF315197.

    Enzyme and pathway databases

    Reactomei REACT_198199. Synthesis of PIPs at the early endosome membrane.
    REACT_198210. Synthesis of PIPs at the late endosome membrane.

    Miscellaneous databases

    NextBioi 20822109.
    PROi Q5ZIV1.

    Family and domain databases

    Gene3Di 2.30.29.30. 1 hit.
    InterProi IPR004182. GRAM.
    IPR010569. Myotubularin-like_Pase_dom.
    IPR011993. PH_like_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    Pfami PF02893. GRAM. 1 hit.
    PF06602. Myotub-related. 1 hit.
    [Graphical view ]
    SMARTi SM00568. GRAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS51339. PPASE_MYOTUBULARIN. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: CB.
      Tissue: Bursa of Fabricius.

    Entry informationi

    Entry nameiMTMR2_CHICK
    AccessioniPrimary (citable) accession number: Q5ZIV1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 16, 2008
    Last sequence update: November 23, 2004
    Last modified: September 3, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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