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Protein

Myotubularin-related protein 2

Gene

MTMR2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (By similarity).By similarity

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.By similarity
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei345 – 3451Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei391 – 3911SubstrateBy similarity

GO - Molecular functioni

  1. phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity Source: UniProtKB
  2. phosphatidylinositol-3-phosphatase activity Source: UniProtKB
  3. protein tyrosine phosphatase activity Source: InterPro

GO - Biological processi

  1. phosphatidylinositol dephosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid metabolism

Enzyme and pathway databases

ReactomeiREACT_341703. Synthesis of PIPs at the early endosome membrane.
REACT_344554. Synthesis of PIPs at the late endosome membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 2
Alternative name(s):
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase (EC:3.1.3.95By similarity)
Phosphatidylinositol-3-phosphate phosphatase (EC:3.1.3.64By similarity)
Gene namesi
Name:MTMR2
ORF Names:RCJMB04_23g22
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Chromosome 1

Subcellular locationi

Cytoplasm By similarity. Early endosome membrane By similarity; Peripheral membrane protein By similarity
Note: Partly associated with membranes.By similarity

GO - Cellular componenti

  1. cytosol Source: UniProtKB
  2. early endosome membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 571571Myotubularin-related protein 2PRO_0000356229Add
BLAST

Proteomic databases

PaxDbiQ5ZIV1.

Expressioni

Gene expression databases

ExpressionAtlasiQ5ZIV1. baseline.

Interactioni

Subunit structurei

Homooligomer and heterooligomer.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000027747.

Structurei

3D structure databases

ProteinModelPortaliQ5ZIV1.
SMRiQ5ZIV1. Positions 1-514.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 6767GRAMAdd
BLAST
Domaini133 – 508376Myotubularin phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni258 – 2614Substrate bindingBy similarity
Regioni283 – 2842Substrate bindingBy similarity
Regioni345 – 3517Substrate bindingBy similarity

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili521 – 55333Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 GRAM domain.Curated
Contains 1 myotubularin phosphatase domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG322789.
GeneTreeiENSGT00760000118832.
HOGENOMiHOG000210598.
HOVERGENiHBG000220.
InParanoidiQ5ZIV1.
KOiK18081.
OrthoDBiEOG7XDBF9.
PhylomeDBiQ5ZIV1.
TreeFamiTF315197.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR004182. GRAM.
IPR010569. Myotubularin-like_Pase_dom.
IPR030564. Myotubularin_fam.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10807. PTHR10807. 1 hit.
PfamiPF02893. GRAM. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SMARTiSM00568. GRAM. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZIV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEPPLLPGE TIKDMAKDVT YICPFTGAIR GTLTVTNYRL YFKSMERDPP
60 70 80 90 100
FVLDASLGVI NRVEKIGGAS SRGENSYGLE IVCKDIRNLR FAHKPEGRTR
110 120 130 140 150
RSIFENLMKY AFPVSNNLPL FAFEYKEVFP ENGWKVYDPI WEYRRQGIPN
160 170 180 190 200
ESWRLSKINE HYELCDTYPA ILAVPVNIPD EELKRVASFR SRGRIPVLSW
210 220 230 240 250
IHPESQATIT RCSQPMVGVS GKRSKEDEKY LQAIMDSNAQ SHKIFIFDAR
260 270 280 290 300
PSVNAVANKA KGGGYESEDA YQNAELVFLD IHNIHVMRES LRKLKEIVYP
310 320 330 340 350
NIEETHWLSN LESTHWLEHI KLILAGALRI ADKVESGKTS VVVHCSDGWD
360 370 380 390 400
RTAQLTSLSL LMLDGYYRTI RGFEVLVEKE WLSFGHRFQL RVGHGDKNHA
410 420 430 440 450
DADRSPVFLQ FIDCVWQMTR QFPTAFEFNE YFLITILDHL YSCLFGTFLC
460 470 480 490 500
SSEQQRVKES LPKKTVSLWS YINSQLEDFT NPLYVSYSNH VLYPVASMRH
510 520 530 540 550
LELWVGYYIR WNPRMKPQEP VHNRYKELLA KRAELQKKVE ELQREITNRS
560 570
TSSSERAGSP AQCVTPVQTV V
Length:571
Mass (Da):65,968
Last modified:November 22, 2004 - v1
Checksum:i6C984994DCB04B27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720683 mRNA. Translation: CAG32342.1.
RefSeqiNP_001034363.1. NM_001039274.1.
UniGeneiGga.2647.

Genome annotation databases

EnsembliENSGALT00000027800; ENSGALP00000027747; ENSGALG00000017200.
GeneIDi418992.
KEGGigga:418992.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720683 mRNA. Translation: CAG32342.1.
RefSeqiNP_001034363.1. NM_001039274.1.
UniGeneiGga.2647.

3D structure databases

ProteinModelPortaliQ5ZIV1.
SMRiQ5ZIV1. Positions 1-514.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000027747.

Proteomic databases

PaxDbiQ5ZIV1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000027800; ENSGALP00000027747; ENSGALG00000017200.
GeneIDi418992.
KEGGigga:418992.

Organism-specific databases

CTDi8898.

Phylogenomic databases

eggNOGiNOG322789.
GeneTreeiENSGT00760000118832.
HOGENOMiHOG000210598.
HOVERGENiHBG000220.
InParanoidiQ5ZIV1.
KOiK18081.
OrthoDBiEOG7XDBF9.
PhylomeDBiQ5ZIV1.
TreeFamiTF315197.

Enzyme and pathway databases

ReactomeiREACT_341703. Synthesis of PIPs at the early endosome membrane.
REACT_344554. Synthesis of PIPs at the late endosome membrane.

Miscellaneous databases

NextBioi20822109.
PROiQ5ZIV1.

Gene expression databases

ExpressionAtlasiQ5ZIV1. baseline.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR004182. GRAM.
IPR010569. Myotubularin-like_Pase_dom.
IPR030564. Myotubularin_fam.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10807. PTHR10807. 1 hit.
PfamiPF02893. GRAM. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SMARTiSM00568. GRAM. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiMTMR2_CHICK
AccessioniPrimary (citable) accession number: Q5ZIV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2008
Last sequence update: November 22, 2004
Last modified: March 31, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.