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Q5ZIV1 (MTMR2_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myotubularin-related protein 2

EC=3.1.3.-
Gene names
Name:MTMR2
ORF Names:RCJMB04_23g22
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length571 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate By similarity.

Subunit structure

Homooligomer and heterooligomer By similarity.

Subcellular location

Cytoplasm. Membrane; Peripheral membrane protein. Note: Partly associated with membranes By similarity.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.

Contains 1 GRAM domain.

Contains 1 myotubularin phosphatase domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Membrane
   DomainCoiled coil
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein tyrosine phosphatase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 571571Myotubularin-related protein 2
PRO_0000356229

Regions

Domain1 – 6767GRAM
Domain133 – 508376Myotubularin phosphatase
Region258 – 2614Substrate binding By similarity
Region283 – 2842Substrate binding By similarity
Region345 – 3517Substrate binding By similarity
Coiled coil521 – 55333 Potential

Sites

Active site3451Phosphocysteine intermediate By similarity
Binding site3911Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5ZIV1 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 6C984994DCB04B27

FASTA57165,968
        10         20         30         40         50         60 
MEEPPLLPGE TIKDMAKDVT YICPFTGAIR GTLTVTNYRL YFKSMERDPP FVLDASLGVI 

        70         80         90        100        110        120 
NRVEKIGGAS SRGENSYGLE IVCKDIRNLR FAHKPEGRTR RSIFENLMKY AFPVSNNLPL 

       130        140        150        160        170        180 
FAFEYKEVFP ENGWKVYDPI WEYRRQGIPN ESWRLSKINE HYELCDTYPA ILAVPVNIPD 

       190        200        210        220        230        240 
EELKRVASFR SRGRIPVLSW IHPESQATIT RCSQPMVGVS GKRSKEDEKY LQAIMDSNAQ 

       250        260        270        280        290        300 
SHKIFIFDAR PSVNAVANKA KGGGYESEDA YQNAELVFLD IHNIHVMRES LRKLKEIVYP 

       310        320        330        340        350        360 
NIEETHWLSN LESTHWLEHI KLILAGALRI ADKVESGKTS VVVHCSDGWD RTAQLTSLSL 

       370        380        390        400        410        420 
LMLDGYYRTI RGFEVLVEKE WLSFGHRFQL RVGHGDKNHA DADRSPVFLQ FIDCVWQMTR 

       430        440        450        460        470        480 
QFPTAFEFNE YFLITILDHL YSCLFGTFLC SSEQQRVKES LPKKTVSLWS YINSQLEDFT 

       490        500        510        520        530        540 
NPLYVSYSNH VLYPVASMRH LELWVGYYIR WNPRMKPQEP VHNRYKELLA KRAELQKKVE 

       550        560        570 
ELQREITNRS TSSSERAGSP AQCVTPVQTV V 

« Hide

References

[1]"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis."
Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.
Genome Biol. 6:R6.1-R6.9(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: CB.
Tissue: Bursa of Fabricius.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ720683 mRNA. Translation: CAG32342.1.
RefSeqNP_001034363.1. NM_001039274.1.
UniGeneGga.2647.

3D structure databases

ProteinModelPortalQ5ZIV1.
SMRQ5ZIV1. Positions 1-514.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000027747.

Proteomic databases

PaxDbQ5ZIV1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000027800; ENSGALP00000027747; ENSGALG00000017200.
GeneID418992.
KEGGgga:418992.

Organism-specific databases

CTD8898.

Phylogenomic databases

eggNOGNOG322789.
GeneTreeENSGT00670000097670.
HOGENOMHOG000210598.
HOVERGENHBG000220.
InParanoidQ5ZIV1.
KOK18081.
OMAPENGWKV.
OrthoDBEOG7XDBF9.
PhylomeDBQ5ZIV1.
TreeFamTF315197.

Family and domain databases

Gene3D2.30.29.30. 1 hit.
InterProIPR004182. GRAM.
IPR010569. Myotubularin-like_Pase_dom.
IPR011993. PH_like_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PfamPF02893. GRAM. 1 hit.
PF06602. Myotub-related. 1 hit.
[Graphical view]
SMARTSM00568. GRAM. 1 hit.
[Graphical view]
SUPFAMSSF52799. SSF52799. 1 hit.
PROSITEPS51339. PPASE_MYOTUBULARIN. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20822109.
PROQ5ZIV1.

Entry information

Entry nameMTMR2_CHICK
AccessionPrimary (citable) accession number: Q5ZIV1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: November 23, 2004
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families