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Protein

Myotubularin-related protein 2

Gene

MTMR2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate (By similarity).By similarity

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate.By similarity
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei345Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei391SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid metabolism

Enzyme and pathway databases

ReactomeiR-GGA-1483248 Synthesis of PIPs at the ER membrane
R-GGA-1660516 Synthesis of PIPs at the early endosome membrane
R-GGA-1660517 Synthesis of PIPs at the late endosome membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Myotubularin-related protein 2
Alternative name(s):
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase (EC:3.1.3.95By similarity)
Phosphatidylinositol-3-phosphate phosphatase (EC:3.1.3.64By similarity)
Gene namesi
Name:MTMR2
ORF Names:RCJMB04_23g22
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003562291 – 571Myotubularin-related protein 2Add BLAST571

Proteomic databases

PaxDbiQ5ZIV1

Expressioni

Gene expression databases

BgeeiENSGALG00000017200
ExpressionAtlasiQ5ZIV1 baseline and differential

Interactioni

Subunit structurei

Homooligomer and heterooligomer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000027747

Structurei

3D structure databases

ProteinModelPortaliQ5ZIV1
SMRiQ5ZIV1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 67GRAMAdd BLAST67
Domaini133 – 508Myotubularin phosphatasePROSITE-ProRule annotationAdd BLAST376

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni258 – 261Substrate bindingBy similarity4
Regioni283 – 284Substrate bindingBy similarity2
Regioni345 – 351Substrate bindingBy similarity7

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili521 – 553Sequence analysisAdd BLAST33

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG1089 Eukaryota
ENOG410XPTU LUCA
GeneTreeiENSGT00760000118832
HOGENOMiHOG000210598
HOVERGENiHBG000220
InParanoidiQ5ZIV1
KOiK18081
PhylomeDBiQ5ZIV1
TreeFamiTF315197

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR004182 GRAM
IPR010569 Myotubularin-like_Pase_dom
IPR030564 Myotubularin_fam
IPR011993 PH-like_dom_sf
IPR029021 Prot-tyrosine_phosphatase-like
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PANTHERiPTHR10807 PTHR10807, 1 hit
PfamiView protein in Pfam
PF02893 GRAM, 1 hit
PF06602 Myotub-related, 1 hit
SMARTiView protein in SMART
SM00568 GRAM, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS51339 PPASE_MYOTUBULARIN, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5ZIV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEPPLLPGE TIKDMAKDVT YICPFTGAIR GTLTVTNYRL YFKSMERDPP
60 70 80 90 100
FVLDASLGVI NRVEKIGGAS SRGENSYGLE IVCKDIRNLR FAHKPEGRTR
110 120 130 140 150
RSIFENLMKY AFPVSNNLPL FAFEYKEVFP ENGWKVYDPI WEYRRQGIPN
160 170 180 190 200
ESWRLSKINE HYELCDTYPA ILAVPVNIPD EELKRVASFR SRGRIPVLSW
210 220 230 240 250
IHPESQATIT RCSQPMVGVS GKRSKEDEKY LQAIMDSNAQ SHKIFIFDAR
260 270 280 290 300
PSVNAVANKA KGGGYESEDA YQNAELVFLD IHNIHVMRES LRKLKEIVYP
310 320 330 340 350
NIEETHWLSN LESTHWLEHI KLILAGALRI ADKVESGKTS VVVHCSDGWD
360 370 380 390 400
RTAQLTSLSL LMLDGYYRTI RGFEVLVEKE WLSFGHRFQL RVGHGDKNHA
410 420 430 440 450
DADRSPVFLQ FIDCVWQMTR QFPTAFEFNE YFLITILDHL YSCLFGTFLC
460 470 480 490 500
SSEQQRVKES LPKKTVSLWS YINSQLEDFT NPLYVSYSNH VLYPVASMRH
510 520 530 540 550
LELWVGYYIR WNPRMKPQEP VHNRYKELLA KRAELQKKVE ELQREITNRS
560 570
TSSSERAGSP AQCVTPVQTV V
Length:571
Mass (Da):65,968
Last modified:November 23, 2004 - v1
Checksum:i6C984994DCB04B27
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720683 mRNA Translation: CAG32342.1
RefSeqiNP_001034363.1, NM_001039274.1
XP_015135444.1, XM_015279958.1
XP_015135452.1, XM_015279966.1
XP_015135459.1, XM_015279973.1
UniGeneiGga.2647

Genome annotation databases

EnsembliENSGALT00000027800; ENSGALP00000027747; ENSGALG00000017200
ENSGALT00000044926; ENSGALP00000042583; ENSGALG00000017200
GeneIDi418992
KEGGigga:418992

Similar proteinsi

Entry informationi

Entry nameiMTMR2_CHICK
AccessioniPrimary (citable) accession number: Q5ZIV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: November 23, 2004
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health