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Protein

Katanin p80 WD40 repeat-containing subunit B1

Gene

KATNB1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Katanin p80 WD40 repeat-containing subunit B1UniRule annotation
Short name:
Katanin p80 subunit B1UniRule annotation
Alternative name(s):
p80 kataninUniRule annotation
Gene namesi
Name:KATNB1UniRule annotation
ORF Names:RCJMB04_23h13
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 11

Subcellular locationi

  • Cytoplasm UniRule annotation
  • Cytoplasmcytoskeletonmicrotubule organizing centercentrosome UniRule annotation
  • Cytoplasmcytoskeletonspindle pole UniRule annotation
  • Cytoplasmcytoskeleton UniRule annotation

  • Note: Predominantly cytoplasmic. Localized to the interphase centrosome and mitotic spindle poles.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 657657Katanin p80 WD40 repeat-containing subunit B1PRO_0000051052Add
BLAST

Proteomic databases

PaxDbiQ5ZIU8.

Expressioni

Gene expression databases

BgeeiENSGALG00000001041.

Interactioni

Subunit structurei

Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome.UniRule annotation

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039652.

Structurei

3D structure databases

ProteinModelPortaliQ5ZIU8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati18 – 5841WD 1Add
BLAST
Repeati61 – 10040WD 2Add
BLAST
Repeati103 – 14240WD 3Add
BLAST
Repeati145 – 18440WD 4Add
BLAST
Repeati187 – 22640WD 5Add
BLAST
Repeati229 – 26941WD 6Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat KATNB1 family.UniRule annotation
Contains 6 WD repeats.UniRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0267. Eukaryota.
ENOG410XQAC. LUCA.
GeneTreeiENSGT00810000125363.
HOGENOMiHOG000008039.
HOVERGENiHBG052294.
InParanoidiQ5ZIU8.
KOiK18643.
OMAiAWKLQEF.
OrthoDBiEOG091G0DTV.
PhylomeDBiQ5ZIU8.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_03022. Katanin_p80_B1. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR026962. Katanin_bsu1.
IPR028021. Katanin_C-terminal.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF13925. Katanin_con80. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZIU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVVTKTA WKLQEIVAHS SNVSSLVLGK STGRLLATGG DDCRVNVWSV
60 70 80 90 100
NKPNCVMSLT GHTTPIESLQ ISAKEELIVA GSQSGSIRVW DLEAAKILRT
110 120 130 140 150
LLGHKANICS LDFHPYGSFV ASGSLDTDIK LWDVRRKGCI FKYKSHTQAV
160 170 180 190 200
RCLRFSPDGK WLASAADDHT VKLWDLTAGK VMFEFTGHSG PVNVVEFHPS
210 220 230 240 250
EYLLASGSSD RTIRFWDLEK FHVVSCIEEE ATPVRCILFN PDGCCLYGGF
260 270 280 290 300
QDSLRVYGWE PERCFDVVVV NWGKVADLSV CHNQLIGVSF AQSTVSSFVV
310 320 330 340 350
DLSRVTKSGS VPHGLLRNNE LLAQPTPTGS SLRRSYDRPS TSCSKPQRVK
360 370 380 390 400
HSSESERRSP SSEEDRDEKE SKAEIQNPED YKEIFQPRNA ISRTPPHINE
410 420 430 440 450
PFPAPPEDEP ITAKEAVKPN QPVEVQTPLP KQELPETFQR PPIASSTPMP
460 470 480 490 500
RAEPSVIPAA RNEPIGLKAS DFLPALKNQS QAELTDEEIM SQIRKGHKTV
510 520 530 540 550
CMVLTSRHKN LDTVRAVWST SDMKNSVDAA VATNDLSVVV DLLNIVNQTA
560 570 580 590 600
SLWKLDLCTV VLPQIEKLLQ SKYESYVQTG CTSLKLILQR FLPLITDILA
610 620 630 640 650
APPSVGVDIT REERLHKCRL CYKQLKNISN IVKNKSGLSG RHGSAFRELH

LLMAVLE
Length:657
Mass (Da):72,738
Last modified:January 9, 2007 - v2
Checksum:i0FB994B5A912B828
GO

Sequence cautioni

The sequence CAG32345 differs from that shown. Reason: Frameshift at positions 51 and 59. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441R → Q in CAG32345 (PubMed:15642098).Curated
Sequence conflicti347 – 3471Q → QS in CAG32345 (PubMed:15642098).Curated
Sequence conflicti359 – 3591S → N in ABD72238 (Ref. 1) Curated
Sequence conflicti431 – 4311K → T in ABD72238 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ410670 mRNA. Translation: ABD72238.1.
AJ720686 mRNA. Translation: CAG32345.1. Frameshift.
RefSeqiNP_001025730.2. NM_001030559.2.
XP_015147779.1. XM_015292293.1.
UniGeneiGga.7972.

Genome annotation databases

EnsembliENSGALT00000040450; ENSGALP00000039652; ENSGALG00000001041.
GeneIDi415631.
KEGGigga:415631.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ410670 mRNA. Translation: ABD72238.1.
AJ720686 mRNA. Translation: CAG32345.1. Frameshift.
RefSeqiNP_001025730.2. NM_001030559.2.
XP_015147779.1. XM_015292293.1.
UniGeneiGga.7972.

3D structure databases

ProteinModelPortaliQ5ZIU8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039652.

Proteomic databases

PaxDbiQ5ZIU8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000040450; ENSGALP00000039652; ENSGALG00000001041.
GeneIDi415631.
KEGGigga:415631.

Organism-specific databases

CTDi10300.

Phylogenomic databases

eggNOGiKOG0267. Eukaryota.
ENOG410XQAC. LUCA.
GeneTreeiENSGT00810000125363.
HOGENOMiHOG000008039.
HOVERGENiHBG052294.
InParanoidiQ5ZIU8.
KOiK18643.
OMAiAWKLQEF.
OrthoDBiEOG091G0DTV.
PhylomeDBiQ5ZIU8.

Miscellaneous databases

PROiQ5ZIU8.

Gene expression databases

BgeeiENSGALG00000001041.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
HAMAPiMF_03022. Katanin_p80_B1. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR026962. Katanin_bsu1.
IPR028021. Katanin_C-terminal.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF13925. Katanin_con80. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKTNB1_CHICK
AccessioniPrimary (citable) accession number: Q5ZIU8
Secondary accession number(s): Q204L7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: January 9, 2007
Last modified: September 7, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.