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Protein

Dual specificity tyrosine-phosphorylation-regulated kinase 2

Gene

DYRK2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Serine/threonine-protein kinase involved in the control of mitotic transition and the regulation of cellular growth and/or development.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Protein has several cofactor binding sites:
  • Mg2+By similarity
  • Mn2+By similarity

Enzyme regulationi

Autophosphorylates on tyrosine residues.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei176 – 1761ATPPROSITE-ProRule annotationBy similarity
Active sitei273 – 2731Proton acceptorPROSITE-ProRule annotationBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi153 – 1619ATPPROSITE-ProRule annotationBy similarity
Nucleotide bindingi226 – 2294ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC:2.7.12.1)
Gene namesi
Name:DYRK2By similarity
ORF Names:RCJMB04_23i19
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Dual specificity tyrosine-phosphorylation-regulated kinase 2PRO_0000291266Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei31 – 311Phosphothreonine; by ATMBy similarity
Modified residuei307 – 3071PhosphotyrosineBy similarity
Modified residuei367 – 3671Phosphoserine; by ATMBy similarity

Post-translational modificationi

Phosphorylated on serine/threonine residues. Phosphorylation on Thr-31 and Ser-367 by ATM in response to genotoxic stress disrupts MDM2 binding and prevents MDM2-mediated ubiquitination and subsequent proteasome degradation, thus promoting p53/TP53-mediated apoptosis (By similarity).By similarity
Ubiquitination in nucleus by MDM2 in normal conditions leads to proteasome degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ5ZIU3.

Interactioni

Subunit structurei

Interacts with MDM2.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000016084.

Structurei

3D structure databases

ProteinModelPortaliQ5ZIU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini147 – 460314Protein kinasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi114 – 1163Nuclear localization signalBy similarity

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0667. Eukaryota.
ENOG410XPET. LUCA.
GeneTreeiENSGT00760000119032.
HOGENOMiHOG000220863.
HOVERGENiHBG051426.
InParanoidiQ5ZIU3.
KOiK18669.
OMAiKLTTFEH.
OrthoDBiEOG77127N.
PhylomeDBiQ5ZIU3.
TreeFamiTF314624.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZIU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEHLHVGSH GQIQVQQLFE DNSNKRTVLT TQPNGLTTLG KSGLPVVQDR
60 70 80 90 100
QSESAHRRQG SSSSLKSTDG TGKVKASVMT PEQAMKQYMQ KLTTFEHNEI
110 120 130 140 150
FGYTEIYFLG PNAKKRQGVI GGPNNCGYDD DQGSYIQVPH DHIAYRYEVL
160 170 180 190 200
KVIGKGSFGQ VVKAYDHKMH QHVALKMVRN EKRFHRQAAE EIRILEHLRK
210 220 230 240 250
QDKDNNMNVI HMLENFTFRS HICMTFELLS MNLYELIKKN KFQGFSLPLV
260 270 280 290 300
RKFAHSILQC LDALHKNRII HCDLKPENIL LKQQGRSGIK VIDFGSSCYE
310 320 330 340 350
HQRVYTYIQS RFYRAPEVIL GARYGMPIDM WSLGCILAEL LTGYPLLPGE
360 370 380 390 400
DEGDQLACMI ELLGMPSPKL LDSSKRAKNF VSSKGYPRYC TITTLSDGSI
410 420 430 440 450
ILNGGRSRRG KLRGPPESRE WGNALKGCDD PLFLDFLKQC LEWDPAIRMT
460 470 480 490 500
PSQALRHPWL RRRLPKPPTG EKASAKRITE STGAITSISK LPPTSSSASK
510 520
LRTNLAQMTD ANGNIQQRTV LPKLVS
Length:526
Mass (Da):59,437
Last modified:November 23, 2004 - v1
Checksum:iE294B808874225A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720691 mRNA. Translation: CAG32350.1.
RefSeqiNP_001026651.1. NM_001031480.1.
XP_015137471.1. XM_015281985.1.
XP_015137476.1. XM_015281990.1.
UniGeneiGga.13455.
Gga.14403.
Gga.17896.

Genome annotation databases

EnsembliENSGALT00000016103; ENSGALP00000016084; ENSGALG00000009901.
GeneIDi427864.
KEGGigga:427864.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720691 mRNA. Translation: CAG32350.1.
RefSeqiNP_001026651.1. NM_001031480.1.
XP_015137471.1. XM_015281985.1.
XP_015137476.1. XM_015281990.1.
UniGeneiGga.13455.
Gga.14403.
Gga.17896.

3D structure databases

ProteinModelPortaliQ5ZIU3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000016084.

Proteomic databases

PaxDbiQ5ZIU3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000016103; ENSGALP00000016084; ENSGALG00000009901.
GeneIDi427864.
KEGGigga:427864.

Organism-specific databases

CTDi8445.

Phylogenomic databases

eggNOGiKOG0667. Eukaryota.
ENOG410XPET. LUCA.
GeneTreeiENSGT00760000119032.
HOGENOMiHOG000220863.
HOVERGENiHBG051426.
InParanoidiQ5ZIU3.
KOiK18669.
OMAiKLTTFEH.
OrthoDBiEOG77127N.
PhylomeDBiQ5ZIU3.
TreeFamiTF314624.

Miscellaneous databases

NextBioi20829009.
PROiQ5ZIU3.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CBImported.
    Tissue: Bursa of FabriciusImported.

Entry informationi

Entry nameiDYRK2_CHICK
AccessioniPrimary (citable) accession number: Q5ZIU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 12, 2007
Last sequence update: November 23, 2004
Last modified: May 11, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.