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Protein

Protein shisa-5

Gene

Shisa5

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Can induce apoptosis in a caspase-depenent manner and plays a role in p53/TP53-dependent apoptosis.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein shisa-5
Alternative name(s):
Scotin
Gene namesi
Name:Shisa5
Synonyms:Scotin
ORF Names:RCJMB04_23m20
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003128821 – 139Protein shisa-5Add BLAST139

Proteomic databases

PaxDbiQ5ZIS9.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi44 – 50Poly-Thr7
Compositional biasi55 – 137Pro-richAdd BLAST83

Domaini

The proline-rich region is required for endoplasmic reticulum localization.By similarity

Sequence similaritiesi

Belongs to the shisa family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JREX. Eukaryota.
ENOG410YNKU. LUCA.
HOGENOMiHOG000063715.
HOVERGENiHBG106208.
InParanoidiQ5ZIS9.
KOiK10135.
PhylomeDBiQ5ZIS9.

Family and domain databases

InterProiIPR026910. Shisa.
[Graphical view]
PfamiPF13908. Shisa. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZIS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFGTLVAIG VIVFAVVVIT IILCLTCSCC CLYKACRRPQ PVVTTTTATT
60 70 80 90 100
VVHAPYPQQQ GVPPSYPAAP YQGYQPVAIQ PQPGMPVAPY PAQYPPPYPM
110 120 130
QPPDPPAYHE TVAAGAGAPY PISQPPYNPA YMDPQKPTY
Length:139
Mass (Da):14,847
Last modified:November 23, 2004 - v1
Checksum:i0C38D9E3BDFCCAE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720705 mRNA. Translation: CAG32364.1.
RefSeqiNP_001025762.1. NM_001030591.2.
UniGeneiGga.7816.

Genome annotation databases

GeneIDi415948.
KEGGigga:415948.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720705 mRNA. Translation: CAG32364.1.
RefSeqiNP_001025762.1. NM_001030591.2.
UniGeneiGga.7816.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ5ZIS9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi415948.
KEGGigga:415948.

Organism-specific databases

CTDi51246.

Phylogenomic databases

eggNOGiENOG410JREX. Eukaryota.
ENOG410YNKU. LUCA.
HOGENOMiHOG000063715.
HOVERGENiHBG106208.
InParanoidiQ5ZIS9.
KOiK10135.
PhylomeDBiQ5ZIS9.

Miscellaneous databases

PROiQ5ZIS9.

Family and domain databases

InterProiIPR026910. Shisa.
[Graphical view]
PfamiPF13908. Shisa. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSHSA5_CHICK
AccessioniPrimary (citable) accession number: Q5ZIS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: November 23, 2004
Last modified: June 8, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.