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Protein

Protein shisa-5

Gene

Shisa5

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Can induce apoptosis in a caspase-depenent manner and plays a role in p53/TP53-dependent apoptosis.By similarity

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein shisa-5
Alternative name(s):
Scotin
Gene namesi
Name:Shisa5
Synonyms:Scotin
ORF Names:RCJMB04_23m20
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei3 – 23HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003128821 – 139Protein shisa-5Add BLAST139

Proteomic databases

PaxDbiQ5ZIS9.

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi44 – 50Poly-Thr7
Compositional biasi55 – 137Pro-richAdd BLAST83

Domaini

The proline-rich region is required for endoplasmic reticulum localization.By similarity

Sequence similaritiesi

Belongs to the shisa family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JREX. Eukaryota.
ENOG410YNKU. LUCA.
HOGENOMiHOG000063715.
HOVERGENiHBG106208.
InParanoidiQ5ZIS9.
KOiK10135.
PhylomeDBiQ5ZIS9.

Family and domain databases

InterProiView protein in InterPro
IPR026910. Shisa.
PfamiView protein in Pfam
PF13908. Shisa. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5ZIS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFGTLVAIG VIVFAVVVIT IILCLTCSCC CLYKACRRPQ PVVTTTTATT
60 70 80 90 100
VVHAPYPQQQ GVPPSYPAAP YQGYQPVAIQ PQPGMPVAPY PAQYPPPYPM
110 120 130
QPPDPPAYHE TVAAGAGAPY PISQPPYNPA YMDPQKPTY
Length:139
Mass (Da):14,847
Last modified:November 23, 2004 - v1
Checksum:i0C38D9E3BDFCCAE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720705 mRNA. Translation: CAG32364.1.
RefSeqiNP_001025762.1. NM_001030591.2.
UniGeneiGga.7816.

Genome annotation databases

GeneIDi415948.
KEGGigga:415948.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSHSA5_CHICK
AccessioniPrimary (citable) accession number: Q5ZIS9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: November 23, 2004
Last modified: June 8, 2016
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families