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Q5ZIP6

- OTU6B_CHICK

UniProt

Q5ZIP6 - OTU6B_CHICK

Protein

OTU domain-containing protein 6B

Gene

OTUD6B

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei164 – 1641By similarity
    Active sitei167 – 1671NucleophileBy similarity
    Active sitei286 – 2861By similarity

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    OTU domain-containing protein 6B (EC:3.4.19.12)
    Gene namesi
    Name:OTUD6B
    ORF Names:RCJMB04_24h18
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 302302OTU domain-containing protein 6BPRO_0000076281Add
    BLAST

    Proteomic databases

    PaxDbiQ5ZIP6.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000025612.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5ZIP6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini156 – 293138OTUPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni161 – 1677Cys-loopBy similarity
    Regioni228 – 23811Variable-loopBy similarityAdd
    BLAST
    Regioni276 – 28611His-loopBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 OTU domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5539.
    GeneTreeiENSGT00390000012840.
    HOGENOMiHOG000192906.
    HOVERGENiHBG080227.
    InParanoidiQ5ZIP6.
    KOiK18342.
    OMAiDMYTPEE.
    OrthoDBiEOG7WT42W.
    PhylomeDBiQ5ZIP6.
    TreeFamiTF315010.

    Family and domain databases

    InterProiIPR003323. OTU.
    [Graphical view]
    PfamiPF02338. OTU. 1 hit.
    [Graphical view]
    PROSITEiPS50802. OTU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5ZIP6-1 [UniParc]FASTAAdd to Basket

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    MEGSEDEEAE AGGPLQQLVK RQRREKRELQ AKIQGMKNAV PKNDKKRRKQ    50
    LAEEVAKLEA ELEQKHKEEL KQLKEAMPEQ NKIDSIADGV ANFELEGREQ 100
    QIQHPRISKA QKRREKKAAL EKEREERIAE AEIENLTGAR HLESQKLASL 150
    LAARHLEIKQ IPSDGHCMYR AIEDQLKDHH NSWTVATLRN QTAKYIHSHF 200
    DDFLPFLTNP NTGDMYSKEE FEKYCDDIAN TAAWGGQLEL RALSHILQTP 250
    IEVVQMDSPS IIVGEEYSGK PIILVYMRHA YGLGEHYNSV KLLTDATTEN 300
    GS 302
    Length:302
    Mass (Da):34,542
    Last modified:November 23, 2004 - v1
    Checksum:iD23A118D9F4A6A13
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ720738 mRNA. Translation: CAG32397.1.
    RefSeqiNP_001006347.1. NM_001006347.1.
    UniGeneiGga.16131.

    Genome annotation databases

    EnsembliENSGALT00000025659; ENSGALP00000025612; ENSGALG00000015920.
    GeneIDi420222.
    KEGGigga:420222.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ720738 mRNA. Translation: CAG32397.1 .
    RefSeqi NP_001006347.1. NM_001006347.1.
    UniGenei Gga.16131.

    3D structure databases

    ProteinModelPortali Q5ZIP6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000025612.

    Proteomic databases

    PaxDbi Q5ZIP6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSGALT00000025659 ; ENSGALP00000025612 ; ENSGALG00000015920 .
    GeneIDi 420222.
    KEGGi gga:420222.

    Organism-specific databases

    CTDi 51633.

    Phylogenomic databases

    eggNOGi COG5539.
    GeneTreei ENSGT00390000012840.
    HOGENOMi HOG000192906.
    HOVERGENi HBG080227.
    InParanoidi Q5ZIP6.
    KOi K18342.
    OMAi DMYTPEE.
    OrthoDBi EOG7WT42W.
    PhylomeDBi Q5ZIP6.
    TreeFami TF315010.

    Miscellaneous databases

    NextBioi 20823170.
    PROi Q5ZIP6.

    Family and domain databases

    InterProi IPR003323. OTU.
    [Graphical view ]
    Pfami PF02338. OTU. 1 hit.
    [Graphical view ]
    PROSITEi PS50802. OTU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: CB.
      Tissue: Bursa of Fabricius.

    Entry informationi

    Entry nameiOTU6B_CHICK
    AccessioniPrimary (citable) accession number: Q5ZIP6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3