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Protein

OTU domain-containing protein 6B

Gene

OTUD6B

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei164 – 1641By similarity
Active sitei167 – 1671NucleophileBy similarity
Active sitei286 – 2861By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
OTU domain-containing protein 6B (EC:3.4.19.12)
Gene namesi
Name:OTUD6B
ORF Names:RCJMB04_24h18
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539 Componenti: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302OTU domain-containing protein 6BPRO_0000076281Add
BLAST

Proteomic databases

PaxDbiQ5ZIP6.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000025612.

Structurei

3D structure databases

ProteinModelPortaliQ5ZIP6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini156 – 293138OTUPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni161 – 1677Cys-loopBy similarity
Regioni228 – 23811Variable-loopBy similarityAdd
BLAST
Regioni276 – 28611His-loopBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 OTU domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5539.
GeneTreeiENSGT00390000012840.
HOGENOMiHOG000192906.
HOVERGENiHBG080227.
InParanoidiQ5ZIP6.
KOiK18342.
OMAiAEYMQSH.
OrthoDBiEOG7WT42W.
PhylomeDBiQ5ZIP6.
TreeFamiTF315010.

Family and domain databases

InterProiIPR003323. OTU.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZIP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGSEDEEAE AGGPLQQLVK RQRREKRELQ AKIQGMKNAV PKNDKKRRKQ
60 70 80 90 100
LAEEVAKLEA ELEQKHKEEL KQLKEAMPEQ NKIDSIADGV ANFELEGREQ
110 120 130 140 150
QIQHPRISKA QKRREKKAAL EKEREERIAE AEIENLTGAR HLESQKLASL
160 170 180 190 200
LAARHLEIKQ IPSDGHCMYR AIEDQLKDHH NSWTVATLRN QTAKYIHSHF
210 220 230 240 250
DDFLPFLTNP NTGDMYSKEE FEKYCDDIAN TAAWGGQLEL RALSHILQTP
260 270 280 290 300
IEVVQMDSPS IIVGEEYSGK PIILVYMRHA YGLGEHYNSV KLLTDATTEN

GS
Length:302
Mass (Da):34,542
Last modified:November 23, 2004 - v1
Checksum:iD23A118D9F4A6A13
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720738 mRNA. Translation: CAG32397.1.
RefSeqiNP_001006347.1. NM_001006347.1.
UniGeneiGga.16131.

Genome annotation databases

EnsembliENSGALT00000025659; ENSGALP00000025612; ENSGALG00000015920.
GeneIDi420222.
KEGGigga:420222.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720738 mRNA. Translation: CAG32397.1.
RefSeqiNP_001006347.1. NM_001006347.1.
UniGeneiGga.16131.

3D structure databases

ProteinModelPortaliQ5ZIP6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000025612.

Proteomic databases

PaxDbiQ5ZIP6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000025659; ENSGALP00000025612; ENSGALG00000015920.
GeneIDi420222.
KEGGigga:420222.

Organism-specific databases

CTDi51633.

Phylogenomic databases

eggNOGiCOG5539.
GeneTreeiENSGT00390000012840.
HOGENOMiHOG000192906.
HOVERGENiHBG080227.
InParanoidiQ5ZIP6.
KOiK18342.
OMAiAEYMQSH.
OrthoDBiEOG7WT42W.
PhylomeDBiQ5ZIP6.
TreeFamiTF315010.

Miscellaneous databases

NextBioi20823170.
PROiQ5ZIP6.

Family and domain databases

InterProiIPR003323. OTU.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
PROSITEiPS50802. OTU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiOTU6B_CHICK
AccessioniPrimary (citable) accession number: Q5ZIP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: November 23, 2004
Last modified: February 4, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.