Reviewed, UniProtKB/Swiss-Prot Q5ZIL2 (VPS29_CHICK)

Names and origin

Protein names

Recommended name:
    Vacuolar protein sorting-associated protein 29
    EC=3.1.3.3
Alternative name(s):
    Vesicle protein sorting 29

Gene names

Name:	VPS29
ORF Names:	RCJMB04_25e21

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	186 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (igf2r and m6pr) from endosomes to the trans-Golgi network. Has low protein phosphatase activity By similarity.
Catalytic activity	O-phospho-L(or D)-serine + H2O = L(or D)-serine + phosphate.
Cofactor	Binds 2 zinc ions per subunit By similarity.
Subcellular location	Cytoplasm By similarity. Membrane; Peripheral membrane protein By similarity. Endosome membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the VPS29 family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasm Endosome Membrane
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endosome Inferred from electronic annotation. Source: UniProtKB-KW extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphoserine phosphatase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 186	186	Vacuolar protein sorting-associated protein 29		PRO_0000339650

Sequences

	Sequence		Length	Mass (Da)
	Q5ZIL2-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: B8FFAFD509CD56D6	FASTA	186	20,939
	10 20 30 40 50 60 MAGHRLVLVL GDLHIPHRCN SLPAKFKKLL VPGKIQHILC TGNLCTKDTY DYLKTLAGDV 70 80 90 100 110 120 HVVRGDFDEN LNYPEQKVVT VGQFKIGLIH GHQVIPWGDM ASLALLQRQF DVDILISGHT 130 140 150 160 170 180 HKFEAFEHEN KFYINPGSAT GAYHALENNI IPSFVLMDIQ ASTVVTYVYQ LIGDDVKVER IEYKKS

References

[1]

"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis." Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M. Genome Biol. 6:R6.1-R6.9(2005) [PubMed: 15642098] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: CB. Tissue: Bursa of Fabricius.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ720772 mRNA. Translation: CAG32431.1.
IPI	IPI00589301.
RefSeq	NP_001007838.1.
UniGene	Gga.42539
3D structure databases
HSSP	HSSP built from PDB template 1W24 based on UniProtKB Q9UBQ0.
SMR	Q5ZIL2. Positions 6-186.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5ZIL2.
Genome annotation databases
Ensembl	ENSGALT00000007214; ENSGALP00000007202; ENSGALG00000004529; Gallus gallus. [Genome view] ENSGALT00000039111; ENSGALP00000038322; ENSGALG00000004529; Gallus gallus. [Genome view]
GeneID	416867.
KEGG	gga:416867.
Organism-specific databases
CTD	416867.
Phylogenomic databases
eggNOG	veNOG11496.
HOGENOM	HBG317909.
HOVERGEN	Q5ZIL2.
InParanoid	Q5ZIL2.
PhylomeDB	Q5ZIL2.
Family and domain databases
InterPro	IPR000979. Phosphodiesterase_MJ0936. [Graphical view]
TIGRFAMs	TIGR00040. yfcE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

VPS29_CHICK

Accession

Primary (citable) accession number: Q5ZIL2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	November 23, 2004
Last modified:	February 9, 2010
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)