Q5ZIK0 (P4K2B_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidylinositol 4-kinase type 2-beta
EC=2.7.1.67

Alternative name(s):
Phosphatidylinositol 4-kinase type II-beta

Gene names

Name:	PI4K2B
ORF Names:	RCJMB04_25j21

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	479 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) By similarity.
Catalytic activity	ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.
Subcellular location	Cytoplasm By similarity. Membrane By similarity.
Sequence similarities	Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily. Contains 1 PI3K/PI4K domain.

Ontologies

Keywords
Cellular component	Cytoplasm Membrane
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	1-phosphatidylinositol 4-kinase activity Inferred from electronic annotation. Source: EC ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 479	479	Phosphatidylinositol 4-kinase type 2-beta		PRO_0000285167
Regions
	Domain	127 – 434	308	PI3K/PI4K
	Compositional bias	12 – 15	4	Poly-Leu
	Compositional bias	44 – 51	8	Poly-Glu

Sequences

	Sequence		Length	Mass (Da)
	Q5ZIK0 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 2CB1742BB38BCF70	FASTA	479	53,922
	10 20 30 40 50 60 MESGSEEPDE QLLLLSEPAL HAGPPAGRAA PGGAVRLRGE PGLEEEEEGE EDSGPEGDGE 70 80 90 100 110 120 EEPLLRASGR GRRAGAARDK EPRVGAGHTG HAIDMNTFLD DPEFAEIITR AEQVIECGVL 130 140 150 160 170 180 PERISQGSSG SYFVKDCKGK TIGVFKPKSE EPYGHLNPKW TKYFHKICCP CCFGRGCLVP 190 200 210 220 230 240 NQGYLSEAGA YLVDDKLGLG VVPKTKVVWL VSETFNYSAI DRAKSRGKKY ALEKVPKVAK 250 260 270 280 290 300 KFNRIGLPPK VGSFQLFVEG YKEADYWLRK FETDPLPENT RKEFQSQFER LVILDYVIRN 310 320 330 340 350 360 TDRGNDNWLV RYEKQDDGLN LSDKDIQWTV TEESTIKIAA IDNGLAFPFK HPDEWRAYPF 370 380 390 400 410 420 HWAWLSQAQV PFSQETRDLV LPRISDMNFV QDLCEDLHEL FKTDKGFDKA TFENQMSVMR 430 440 450 460 470 GQILNLTQAL KDGKSPIQLV QMPRVIVERS STGSQGRIVH LSNAFTQTFH SRKPFFSSW

References

[1]

"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis." Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M. Genome Biol. 6:R6.1-R6.9(2005) [PubMed: 15642098] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: CB. Tissue: Bursa of Fabricius.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ720784 mRNA. Translation: CAG32443.1.
IPI	IPI00601455.
RefSeq	NP_001026328.1. NM_001031157.1.
UniGene	Gga.20611.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5ZIK0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	422807.
KEGG	gga:422807.
Organism-specific databases
CTD	55300.
Phylogenomic databases
eggNOG	veNOG06579.
GeneTree	ENSGT00390000010434.
HOGENOM	HBG714361.
HOVERGEN	HBG059542.
InParanoid	Q5ZIK0.
OrthoDB	EOG4XSKPT.
PhylomeDB	Q5ZIK0.
Family and domain databases
InterPro	IPR000403. PI3/4_kinase_cat. [Graphical view]
KO	K13711.
Pfam	PF00454. PI3_PI4_kinase. 1 hit. [Graphical view]
PROSITE	PS00915. PI3_4_KINASE_1. False negative. PS00916. PI3_4_KINASE_2. False negative. PS50290. PI3_4_KINASE_3. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

P4K2B_CHICK

Accession

Primary (citable) accession number: Q5ZIK0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	November 23, 2004
Last modified:	November 16, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program