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Protein

Importin-13

Gene

IPO13

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Importin-13
Short name:
Imp13
Gene namesi
Name:IPO13
ORF Names:RCJMB04_27p9
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003570481 – 958Importin-13Add BLAST958

Proteomic databases

PaxDbiQ5ZIC8
PRIDEiQ5ZIC8

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000016380

Structurei

3D structure databases

ProteinModelPortaliQ5ZIC8
SMRiQ5ZIC8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati19 – 49HEAT 1Add BLAST31
Domaini40 – 106Importin N-terminalAdd BLAST67
Repeati51 – 83HEAT 2Add BLAST33
Repeati90 – 130HEAT 3Add BLAST41
Repeati137 – 174HEAT 4Add BLAST38
Repeati189 – 226HEAT 5Add BLAST38
Repeati231 – 263HEAT 6Add BLAST33
Repeati271 – 320HEAT 7Add BLAST50
Repeati325 – 367HEAT 8Add BLAST43
Repeati370 – 433HEAT 9Add BLAST64
Repeati435 – 471HEAT 10Add BLAST37
Repeati482 – 517HEAT 11Add BLAST36
Repeati519 – 553HEAT 12Add BLAST35
Repeati557 – 595HEAT 13Add BLAST39
Repeati598 – 643HEAT 14Add BLAST46
Repeati671 – 711HEAT 15Add BLAST41
Repeati715 – 749HEAT 16Add BLAST35
Repeati756 – 798HEAT 17Add BLAST43
Repeati810 – 840HEAT 18Add BLAST31
Repeati855 – 888HEAT 19Add BLAST34
Repeati892 – 926HEAT 20Add BLAST35

Sequence similaritiesi

Belongs to the importin beta family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2022 Eukaryota
ENOG410XT8Y LUCA
HOGENOMiHOG000049153
HOVERGENiHBG052141
InParanoidiQ5ZIC8
PhylomeDBiQ5ZIC8

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR013598 Exportin-1/Importin-b-like
PfamiView protein in Pfam
PF08389 Xpo1, 1 hit
SUPFAMiSSF48371 SSF48371, 2 hits

Sequencei

Sequence statusi: Complete.

Q5ZIC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERRAEAPPP PQGLDFTVEN VEKALHQLYY DPNIENKNLA QKWLMQAQVS
60 70 80 90 100
PQAWHFSWLL LNMDKVPEIQ YSAPAPCTSR SPATGTTSLP DQYESLKSQL
110 120 130 140 150
FTHITRFAGG SKIVLTRLCV ALASLALSMM PEAWPCAVAD MVRMFQAEDS
160 170 180 190 200
NVDGRARCLA LLELLTVLPE EFQTSRLPQY RKGQVRSVLA QECGSVFPLL
210 220 230 240 250
EQLLQQQDSP GFIKQKVLKC FSSWVQLEIP LMDCENLIQA AFTSLQDPEL
260 270 280 290 300
FDTAVEAVVN AISQPDAQRY VNTLLKLIPP VLGLQEQLRQ AVQSGDMETS
310 320 330 340 350
HGICRIAVAL GENHSRALLD QVEHWQSFLA LVNMIMFCTG IPGHYPVNET
360 370 380 390 400
TSSLTLTFWY TLQDDILSFE PDKQAVYQQV YRPVYFQLVD VLLHKAQFPS
410 420 430 440 450
DEEYGFWSSD EKEQFRIYRV DISDTLMYVY EMLGAELLSS LYDKLGRLLT
460 470 480 490 500
NTEQPSTWQH TEALLYGFQS IAETIDVNYS DVVPGLIGLI PRISISNVQL
510 520 530 540 550
ADTVMFTIGA LSEWLADHPV MINNVLPLVL QALGNPELSI SSVSTLKKIC
560 570 580 590 600
RECKYDLPPY AANIVAVSQE VLMKQIHKTS QCMWLMQALG FLLSALQVEE
610 620 630 640 650
ILKNLHSLIT PYIQQLEKLA DETPNPSNKL AIIHILGLLS NLFTTLDISH
660 670 680 690 700
HDDDHESTEV KKLPVQQGPN PVVVVLQQVF QLIQKVLSKW LNDAQVVESV
710 720 730 740 750
CAIFEKSVKT LLDDFAPMVP QLCEMLGQMY STIPQASAID LTRQLVHIFA
760 770 780 790 800
HEPAHFPPIK ALFLLVTSVT LTLFQQGPRD HPDIVDSFMQ LLAQALKRKP
810 820 830 840 850
DLFLCSNLDV KALFHCGVLS LKFPEAPTVK ASCGFFTELL PRCGEIAPVG
860 870 880 890 900
QVVHENGKVL LQAVLEGVGG QASRSLMDHF AEILFALNKH CFSYLSIWIK
910 920 930 940 950
EAMQQDGFPS ARVSPEQKET FSQQILRERV NKRRVKEMVK EFTLLCRGLH

GTEYTADY
Length:958
Mass (Da):107,776
Last modified:November 23, 2004 - v1
Checksum:i11905A741DDBF0B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720856 mRNA Translation: CAG32515.1
RefSeqiNP_001006537.1, NM_001006537.1
UniGeneiGga.22612

Genome annotation databases

GeneIDi424573
KEGGigga:424573

Similar proteinsi

Entry informationi

Entry nameiIPO13_CHICK
AccessioniPrimary (citable) accession number: Q5ZIC8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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