Q5ZIB9 (ANM7_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein arginine N-methyltransferase 7
EC=2.1.1.-

Alternative name(s):
Histone-arginine N-methyltransferase PRMT7
EC=2.1.1.125
[Myelin basic protein]-arginine N-methyltransferase PRMT7
EC=2.1.1.126

Gene names

Name:	PRMT7
ORF Names:	RCJMB04_28e13

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	689 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo By similarity.
Catalytic activity	S-adenosyl-L-methionine + arginine-[histone] = S-adenosyl-L-homocysteine + N(omega)-methyl-arginine-[histone]. S-adenosyl-L-methionine + [myelin basic protein]-arginine = S-adenosyl-L-homocysteine + [myelin basic protein]-N(omega)-methyl-arginine.
Subcellular location	Cytoplasm › cytosol By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the protein arginine N-methyltransferase family. PRMT7 subfamily.

Ontologies

Keywords
Biological process	Differentiation Transcription Transcription regulation
Cellular component	Cytoplasm Nucleus
Ligand	S-adenosyl-L-methionine
Molecular function	Chromatin regulator Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	DNA methylation involved in gamete generation Inferred from sequence or structural similarity. Source: UniProtKB cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW regulation of gene expression by genetic imprinting Inferred from sequence or structural similarity. Source: UniProtKB regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW spliceosomal snRNP assembly Inferred from sequence or structural similarity. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytosol Inferred from sequence or structural similarity. Source: UniProtKB nucleus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	[myelin basic protein]-arginine N-methyltransferase activity Inferred from sequence or structural similarity. Source: HGNC histone methyltransferase activity (H4-R3 specific) Inferred from sequence or structural similarity. Source: UniProtKB protein-arginine omega-N monomethyltransferase activity Inferred from sequence or structural similarity. Source: HGNC protein-arginine omega-N symmetric methyltransferase activity Inferred from sequence or structural similarity. Source: HGNC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 689	689	Protein arginine N-methyltransferase 7		PRO_0000373903

Sequences

	Sequence		Length	Mass (Da)
	Q5ZIB9 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: E924B30B918F4109	FASTA	689	78,071
	10 20 30 40 50 60 MKTFCGRANP TTGSLEWVEE DEDYDYHQEI ARSRYADMLH DKDRNMKYYQ GIRAAVSRVK 70 80 90 100 110 120 GRGEKAIVLD IGTGTGLLSM MAASAGADFC YAVEVFKPMA NAAVKIVEKN GFGDKIKVIN 130 140 150 160 170 180 KHSTEVTVGP DGDMQCRANI LVTELFDTEL IGEGALPTYE HAHKYLVQEG CEAVPHRATV 190 200 210 220 230 240 YVQLVESKRM WSWNKLFPVH VEAEDGEKII VSPSEMENCP GVPSVCDIQL NQMPSSDFTI 250 260 270 280 290 300 LSDVVTMFSV DFSKPVRSAS TCYRAQLDPV KSGKAQIVLS WWDIDMDPSG TINCTMAPYW 310 320 330 340 350 360 VKPMSAFQWR DHWMQCVYFL PKEEQVLQGE KVHLTACRDE YSVWYTLQKA REEDESKADA 370 380 390 400 410 420 RVESPVCRCQ AHLLWNRPRF GELNDQNRTR QYIKSLMSVL RTDSVCLCIS DGSLLPVLAH 430 440 450 460 470 480 YLGAEQVFTL ENSAVSCSVM KKFFKANHLE DKIKIVEARP ELLTSSHLEE KKISVLVGEP 490 500 510 520 530 540 FFTTSLLPWH NLYFWYARTA VTEHLASDVT VLPQSAALHM MIVEFQDLWR IRSPCGTCEG 550 560 570 580 590 600 FDVQTMDDMI KNSLNFRESK EAEPHPLWEY PCKSLSNPQE VLLFDFRKTV PQHCLSTEGS 610 620 630 640 650 660 VNLLRKGKSH GAVLWMEYHL TADISVSTGL MQISNEKGNC EWNPHCKQAV YFFSSVIESE 670 680 TLADVPTAVT YAIKFDTKTG EIAMDFKLL

References

[1]

"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis." Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M. Genome Biol. 6:R6.1-R6.9(2005) [PubMed: 15642098] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: CB. Tissue: Bursa of Fabricius.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ720865 mRNA. Translation: CAG32524.1.
IPI	IPI00596532.
RefSeq	NP_001005831.1. NM_001005831.1.
UniGene	Gga.22346.
3D structure databases
ProteinModelPortal	Q5ZIB9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5ZIB9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	415620.
KEGG	gga:415620.
Organism-specific databases
CTD	54496.
Phylogenomic databases
eggNOG	veNOG11828.
GeneTree	ENSGT00530000063495.
HOGENOM	HBG377790.
InParanoid	Q5ZIB9.
OrthoDB	EOG48KR9T.
Family and domain databases
InterPro	IPR014644. Arg_N-MeTrfase. IPR010456. Ribosomal-L11_MeTrfase_PrmA. [Graphical view]
KO	K11438.
Pfam	PF06325. PrmA. 1 hit. [Graphical view]
PIRSF	PIRSF036946. Arg_N-mtase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ANM7_CHICK

Accession

Primary (citable) accession number: Q5ZIB9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	November 23, 2004
Last modified:	November 16, 2011
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program