Q5ZI51 (ARHL2_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Poly(ADP-ribose) glycohydrolase ARH3
EC=3.2.1.143

Alternative name(s):
ADP-ribosylhydrolase 3
[Protein ADP-ribosylarginine] hydrolase-like protein 2

Gene names

Name:	ADPRHL2
Synonyms:	ARH3
ORF Names:	RCJMB04_30e5

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP-ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds By similarity.
Catalytic activity	Hydrolyzes poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose.
Cofactor	Binds 2 magnesium ions per subunit By similarity.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the ADP-ribosylglycohydrolase family.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Ligand	Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW poly(ADP-ribose) glycohydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 367	367	Poly(ADP-ribose) glycohydrolase ARH3		PRO_0000277615
Sites
	Metal binding	41	1	Magnesium 2 By similarity
	Metal binding	79	1	Magnesium 1 By similarity
	Metal binding	80	1	Magnesium 1 By similarity
	Metal binding	81	1	Magnesium 1 By similarity
	Metal binding	317	1	Magnesium 2 By similarity
	Metal binding	320	1	Magnesium 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5ZI51 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 605113FC6622FF89	FASTA	367	39,909
	10 20 30 40 50 60 MAAAGAGSGR AAVSRSRPPP ARFRGCLAGA LLGDCLGAVF EGRSVVKLPD LLSFLRGLEP 70 80 90 100 110 120 PGGEGEPAGS ARRETLSYTD DTAMSRCVVQ SLLAKREFDE VDMAKRFAEE YKKEPNRGYG 130 140 150 160 170 180 MAVVNVFKKL LSPQCSDVFE PARAQFNGKG SYGNGGAMRV AGIPLTYSDV QDVKKFAKLS 190 200 210 220 230 240 AELTHANSLG YNGAILQALA VHLALQGEVS RETFLEQLIS HMEDIEADDK SLTDARALGF 250 260 270 280 290 300 EDLPFSRRLK KIKEFLELSS VPKEDVLFEL GNGIAALRSV PTAIYSFLRC MEADPDIPEH 310 320 330 340 350 360 YNNLQRTIIY CISLGGDTNT IATMAGAIAG AYYGEEQVPP SWEQSCEAFQ ETQKMANSLH ELYCQQL

References

[1]

"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis." Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M. Genome Biol. 6:R6.1-R6.9(2005) [PubMed: 15642098] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: CB. Tissue: Bursa of Fabricius.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ720933 mRNA. Translation: CAG32592.1.
IPI	IPI00587371.
RefSeq	NP_001006312.1. NM_001006312.1.
UniGene	Gga.42574.
3D structure databases
HSSP	HSSP built from PDB template 2CWC based on UniProtKB Q5SMG9.
ProteinModelPortal	Q5ZI51.
SMR	Q5ZI51. Positions 21-363.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	419626.
KEGG	gga:419626.
Organism-specific databases
CTD	54936.
Phylogenomic databases
eggNOG	veNOG05984.
GeneTree	ENSGT00390000015369.
HOGENOM	HBG444652.
HOVERGEN	HBG080863.
InParanoid	Q5ZI51.
OrthoDB	EOG466VMC.
PhylomeDB	Q5ZI51.
Family and domain databases
InterPro	IPR005502. Ribosyl_crysJ1. [Graphical view]
KO	K11687.
Pfam	PF03747. ADP_ribosyl_GH. 1 hit. [Graphical view]
SUPFAM	SSF101478. Ribosyl_crysJ1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARHL2_CHICK

Accession

Primary (citable) accession number: Q5ZI51

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	November 23, 2004
Last modified:	December 14, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program