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Protein

Malignant T-cell-amplified sequence 1

Gene

MCTS1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role as translation enhancer and involved in cell cycle regulation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, Growth regulation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Malignant T-cell-amplified sequence 1
Short name:
MCT-1
Gene namesi
Name:MCTS1
ORF Names:RCJMB04_30h12
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 4

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003447901 – 181Malignant T-cell-amplified sequence 1Add BLAST181

Proteomic databases

PaxDbiQ5ZI42.
PRIDEiQ5ZI42.

Expressioni

Gene expression databases

BgeeiENSGALG00000008517.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013855.

Structurei

3D structure databases

ProteinModelPortaliQ5ZI42.
SMRiQ5ZI42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini92 – 171PUAPROSITE-ProRule annotationAdd BLAST80

Domaini

The PUA RNA-binding domain is critical for cap binding, but not sufficient for translation enhancer function.By similarity

Sequence similaritiesi

Belongs to the MCTS1 family.Curated

Phylogenomic databases

eggNOGiKOG2523. Eukaryota.
COG2016. LUCA.
GeneTreeiENSGT00550000074964.
HOGENOMiHOG000223988.
HOVERGENiHBG105551.
InParanoidiQ5ZI42.
KOiK07575.
OMAiFPSIRID.
OrthoDBiEOG091G0LZ0.
PhylomeDBiQ5ZI42.
TreeFamiTF315123.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
InterProiView protein in InterPro
IPR016437. MCT-1/Tma20.
IPR002478. PUA.
IPR015947. PUA-like_domain.
IPR004521. Uncharacterised_CHP00451.
PANTHERiPTHR22798. PTHR22798. 1 hit.
PfamiView protein in Pfam
PF01472. PUA. 1 hit.
PIRSFiPIRSF005067. Tma_RNA-bind_prd. 1 hit.
SMARTiView protein in SMART
SM00359. PUA. 1 hit.
SUPFAMiSSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00451. unchar_dom_2. 1 hit.
PROSITEiView protein in PROSITE
PS50890. PUA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5ZI42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFKKFDEKEN VSNCIQLKTS VIKGIKNQLI DQFPVIEPWL NQIMPKKDPV
60 70 80 90 100
KIVRCHEHIE ILTVNGELLF FRQREGIFYP TLRLLHKYPF ILPHQQVDKG
110 120 130 140 150
AIKFVLSGAN IMCPGLTSPG AKLYPAAVDT VVAIMAEGKQ HALCVGVMKM
160 170 180
SADDIEKVNK GIGIENIHYL NDGLWHMKTY K
Length:181
Mass (Da):20,571
Last modified:November 23, 2004 - v1
Checksum:i7BA0F4C3A51055CD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720942 mRNA. Translation: CAG32601.1.
RefSeqiNP_001099145.1. NM_001105675.1.
UniGeneiGga.21824.

Genome annotation databases

EnsembliENSGALT00000013871; ENSGALP00000013855; ENSGALG00000008517.
GeneIDi422363.
KEGGigga:422363.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMCTS1_CHICK
AccessioniPrimary (citable) accession number: Q5ZI42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: November 23, 2004
Last modified: June 7, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families