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Protein

Probable lysosomal cobalamin transporter

Gene

LMBRD1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandCobalamin, Cobalt

Names & Taxonomyi

Protein namesi
Recommended name:
Probable lysosomal cobalamin transporter
Alternative name(s):
LMBR1 domain-containing protein 1
Gene namesi
Name:LMBRD1
ORF Names:RCJMB04_31k18
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7ExtracellularSequence analysis7
Transmembranei8 – 28Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini29 – 47CytoplasmicSequence analysisAdd BLAST19
Transmembranei48 – 68Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini69 – 97ExtracellularSequence analysisAdd BLAST29
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 141CytoplasmicSequence analysisAdd BLAST23
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 185ExtracellularSequence analysisAdd BLAST23
Transmembranei186 – 206Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini207 – 302CytoplasmicSequence analysisAdd BLAST96
Transmembranei303 – 323Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini324 – 361ExtracellularSequence analysisAdd BLAST38
Transmembranei362 – 382Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini383 – 405CytoplasmicSequence analysisAdd BLAST23
Transmembranei406 – 426Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini427 – 483ExtracellularSequence analysisAdd BLAST57
Transmembranei484 – 504Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini505 – 539CytoplasmicSequence analysisAdd BLAST35

Keywords - Cellular componenti

Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002605191 – 539Probable lysosomal cobalamin transporterAdd BLAST539

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi85N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi344N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi445N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi454N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ5ZI05.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000031013.

Family & Domainsi

Sequence similaritiesi

Belongs to the LIMR family. LMBRD1 subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFHV. Eukaryota.
ENOG410XPKG. LUCA.
HOGENOMiHOG000068018.
HOVERGENiHBG059142.
InParanoidiQ5ZI05.
KOiK14617.
PhylomeDBiQ5ZI05.

Family and domain databases

InterProiView protein in InterPro
IPR006876. LMBR1-like_membr_prot.
PfamiView protein in Pfam
PF04791. LMBR1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5ZI05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAASELLT GWFLFGLALL AILIFSWVYV RKYQSRRESE VISTVTAIFA
60 70 80 90 100
LAVALISSAL LPVDIFLVSY MKNQNGTFKD WADANVSRQI EDTVLYGYYT
110 120 130 140 150
LYSIILFCVF LWIPFVYFYY EEKEEDDGNT CSQVKTALKY TLGFITVCAV
160 170 180 190 200
LLLIGAFVPL DIPNKKNSTE WEKVKLLFEE FGSSHGLTAL SFSISSLTVI
210 220 230 240 250
GMLAAITYTA YGMSALPLNL IKGTTSAAYE RLENTEDIEE VEQRILRIKS
260 270 280 290 300
KCRDGRPLSS RDRRAVQQLE ERLRTLRRRE RHLETIEKSW WLKFCEAIRP
310 320 330 340 350
LKIVWGVFFI IVALLFTVSL FLSNLDKALH SAGFDSGFII LGTNLTNPLN
360 370 380 390 400
MLLPVLQTVF PLDYILITTI VMYFIFTSMA GIRNMGIWFF WIRLYKIRRG
410 420 430 440 450
KTRPQALLFL CMILLLIVLH TSYMIYSLAP QYVMYGSQKY LVQSNKTIDG
460 470 480 490 500
QPKNVTTFVA KDCDADAPED QCIVTRTYLF LHKFWFFSAV YYFGNWAFIA
510 520 530
VFLIGLIVSC CKGKKSVIEG EVDEDDSDMS DDELSAYYC
Length:539
Mass (Da):61,675
Last modified:November 23, 2004 - v1
Checksum:i2389568E3C8A3FAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720979 mRNA. Translation: CAG32638.1.
RefSeqiNP_001006413.1. NM_001006413.1.
UniGeneiGga.22452.

Genome annotation databases

GeneIDi421874.
KEGGigga:421874.

Similar proteinsi

Entry informationi

Entry nameiLMBD1_CHICK
AccessioniPrimary (citable) accession number: Q5ZI05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 23, 2004
Last modified: July 5, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families