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Protein

Ras-related protein Rap-1b

Gene

RAP1B

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Probable GTP-binding protein that possesses GTPase activity. May play a role in endothelial cell polarity and endothelial barrier function (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178GTPBy similarity
Nucleotide bindingi57 – 615GTPBy similarity
Nucleotide bindingi116 – 1194GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-354192. Integrin alphaIIb beta3 signaling.
R-GGA-354194. GRB2:SOS provides linkage to MAPK signaling for Integrins.
R-GGA-372708. p130Cas linkage to MAPK signaling for integrins.
R-GGA-392517. Rap1 signalling.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rap-1b
Gene namesi
Name:RAP1B
ORF Names:RCJMB04_32g9, RCJMB04_4h13
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181Ras-related protein Rap-1bPRO_0000260753Add
BLAST
Propeptidei182 – 1843Removed in mature formBy similarityPRO_0000260754

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei179 – 1791PhosphoserineBy similarity
Modified residuei181 – 1811Cysteine methyl esterBy similarity
Lipidationi181 – 1811S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiQ5ZHX1.
PRIDEiQ5ZHX1.

Expressioni

Gene expression databases

BgeeiENSGALG00000009927.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000016120.

Structurei

3D structure databases

ProteinModelPortaliQ5ZHX1.
SMRiQ5ZHX1. Positions 1-166.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi32 – 409Effector regionCurated

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121857.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ5ZHX1.
KOiK07836.
OMAiRDSTHPR.
OrthoDBiEOG091G0OOG.
PhylomeDBiQ5ZHX1.
TreeFamiTF313014.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ZHX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREYKLVVLG SGGVGKSALT VQFVQGIFVE KYDPTIEDSY RKQVEVDAQQ
60 70 80 90 100
CMLEILDTAG TEQFTAMRDL YMKNGQGFAL VYSITAQSTF NDLQDLREQI
110 120 130 140 150
LRVKDTDDVP MILVGNKCDL EDERVVGKEQ GQNLARQWNN CAFLESSAKS
160 170 180
KINVNEIFYD LVRQINRKTP VPGKARKKSS CQLL
Length:184
Mass (Da):20,825
Last modified:November 23, 2004 - v1
Checksum:iCE976895E5965224
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719603 mRNA. Translation: CAG31262.1.
AJ721013 mRNA. Translation: CAG32672.1.
RefSeqiNP_001007853.1. NM_001007852.1.
XP_015137180.1. XM_015281694.1.
UniGeneiGga.18937.

Genome annotation databases

EnsembliENSGALT00000016139; ENSGALP00000016120; ENSGALG00000009927.
GeneIDi417840.
KEGGigga:417840.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719603 mRNA. Translation: CAG31262.1.
AJ721013 mRNA. Translation: CAG32672.1.
RefSeqiNP_001007853.1. NM_001007852.1.
XP_015137180.1. XM_015281694.1.
UniGeneiGga.18937.

3D structure databases

ProteinModelPortaliQ5ZHX1.
SMRiQ5ZHX1. Positions 1-166.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000016120.

Proteomic databases

PaxDbiQ5ZHX1.
PRIDEiQ5ZHX1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000016139; ENSGALP00000016120; ENSGALG00000009927.
GeneIDi417840.
KEGGigga:417840.

Organism-specific databases

CTDi417840.

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00780000121857.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ5ZHX1.
KOiK07836.
OMAiRDSTHPR.
OrthoDBiEOG091G0OOG.
PhylomeDBiQ5ZHX1.
TreeFamiTF313014.

Enzyme and pathway databases

ReactomeiR-GGA-354192. Integrin alphaIIb beta3 signaling.
R-GGA-354194. GRB2:SOS provides linkage to MAPK signaling for Integrins.
R-GGA-372708. p130Cas linkage to MAPK signaling for integrins.
R-GGA-392517. Rap1 signalling.

Miscellaneous databases

PROiQ5ZHX1.

Gene expression databases

BgeeiENSGALG00000009927.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRAP1B_CHICK
AccessioniPrimary (citable) accession number: Q5ZHX1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 23, 2004
Last modified: September 7, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.