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Protein

Ras-related protein Rap-1b

Gene

RAP1B

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable GTP-binding protein that possesses GTPase activity. May play a role in endothelial cell polarity and endothelial barrier function (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17GTPBy similarity8
Nucleotide bindingi57 – 61GTPBy similarity5
Nucleotide bindingi116 – 119GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-354192 Integrin alphaIIb beta3 signaling
R-GGA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-GGA-372708 p130Cas linkage to MAPK signaling for integrins
R-GGA-392517 Rap1 signalling
R-GGA-5674135 MAP2K and MAPK activation
R-GGA-6798695 Neutrophil degranulation
R-GGA-8875555 MET activates RAP1 and RAC1

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rap-1b
Gene namesi
Name:RAP1B
ORF Names:RCJMB04_32g9, RCJMB04_4h13
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002607531 – 181Ras-related protein Rap-1bAdd BLAST181
PropeptideiPRO_0000260754182 – 184Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei179PhosphoserineBy similarity1
Modified residuei181Cysteine methyl esterBy similarity1
Lipidationi181S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiQ5ZHX1
PRIDEiQ5ZHX1

Expressioni

Gene expression databases

BgeeiENSGALG00000009927

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000016120

Structurei

3D structure databases

ProteinModelPortaliQ5ZHX1
SMRiQ5ZHX1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 40Effector regionCurated9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133678
HOGENOMiHOG000233973
HOVERGENiHBG009351
InParanoidiQ5ZHX1
KOiK07836
OMAiWGNAPYY
OrthoDBiEOG091G0OOG
PhylomeDBiQ5ZHX1
TreeFamiTF313014

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ZHX1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREYKLVVLG SGGVGKSALT VQFVQGIFVE KYDPTIEDSY RKQVEVDAQQ
60 70 80 90 100
CMLEILDTAG TEQFTAMRDL YMKNGQGFAL VYSITAQSTF NDLQDLREQI
110 120 130 140 150
LRVKDTDDVP MILVGNKCDL EDERVVGKEQ GQNLARQWNN CAFLESSAKS
160 170 180
KINVNEIFYD LVRQINRKTP VPGKARKKSS CQLL
Length:184
Mass (Da):20,825
Last modified:November 23, 2004 - v1
Checksum:iCE976895E5965224
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719603 mRNA Translation: CAG31262.1
AJ721013 mRNA Translation: CAG32672.1
RefSeqiNP_001007853.1, NM_001007852.1
XP_015137180.1, XM_015281694.1
UniGeneiGga.18937

Genome annotation databases

EnsembliENSGALT00000016139; ENSGALP00000016120; ENSGALG00000009927
ENSGALT00000083406; ENSGALP00000060871; ENSGALG00000009927
GeneIDi417840
KEGGigga:417840

Similar proteinsi

Entry informationi

Entry nameiRAP1B_CHICK
AccessioniPrimary (citable) accession number: Q5ZHX1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 23, 2004
Last modified: April 25, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health