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Protein

Ras-related protein Rab-33B

Gene

RAB33B

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking (By similarity). It is involved in autophagy, acting as a modulator of autophagosome formation (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi37 – 448GTPBy similarity
Nucleotide bindingi86 – 905GTPBy similarity
Nucleotide bindingi146 – 1494GTPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Autophagy, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-6811438. Intra-Golgi traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-33B
Gene namesi
Name:RAB33B
ORF Names:RCJMB04_32p6
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 4

Subcellular locationi

  • Golgi apparatus membrane By similarity; Lipid-anchor Curated
  • Golgi apparatuscis-Golgi network By similarity

  • Note: Under starvation conditions punctate RAB33B-positive structures are often observed in the cytoplasm.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228228Ras-related protein Rab-33BPRO_0000261126Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi226 – 2261S-geranylgeranyl cysteineBy similarity
Modified residuei228 – 2281Cysteine methyl esterBy similarity
Lipidationi228 – 2281S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ5ZHV1.
PRIDEiQ5ZHV1.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015909.

Structurei

3D structure databases

ProteinModelPortaliQ5ZHV1.
SMRiQ5ZHV1. Positions 28-200.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0084. Eukaryota.
ENOG410XQN5. LUCA.
GeneTreeiENSGT00840000129698.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ5ZHV1.
KOiK07920.
OMAiPAWIEEC.
OrthoDBiEOG78PVB5.
PhylomeDBiQ5ZHV1.
TreeFamiTF300097.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZHV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAELESSLE LSFTGSGTVP GGGLPPARSR IFKIIVIGDS NVGKTCLTYR
60 70 80 90 100
FCAGRFPQRT EATIGVDFRE RAVTIDGERI KIQLWDTAGQ ERFRKSMVQH
110 120 130 140 150
YYRNVHAVVF VYDMTNLASF HSLPSWIEEC KQHLLTNDIP RILVGNKCDL
160 170 180 190 200
RNAIQVPTDL AQKFADTHSM PLFETSAKNP NDNDHVEAIF MTLAHKLKSH
210 220
KPLMLSQPPD RDQIHIKPEP KPAMTCWC
Length:228
Mass (Da):25,736
Last modified:November 23, 2004 - v1
Checksum:iF184179BF6CA609C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ721033 mRNA. Translation: CAG32692.1.
RefSeqiNP_001008466.1. NM_001008466.1.
UniGeneiGga.2252.

Genome annotation databases

EnsembliENSGALT00000015926; ENSGALP00000015909; ENSGALG00000009790.
GeneIDi422441.
KEGGigga:422441.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ721033 mRNA. Translation: CAG32692.1.
RefSeqiNP_001008466.1. NM_001008466.1.
UniGeneiGga.2252.

3D structure databases

ProteinModelPortaliQ5ZHV1.
SMRiQ5ZHV1. Positions 28-200.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015909.

Proteomic databases

PaxDbiQ5ZHV1.
PRIDEiQ5ZHV1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000015926; ENSGALP00000015909; ENSGALG00000009790.
GeneIDi422441.
KEGGigga:422441.

Organism-specific databases

CTDi83452.

Phylogenomic databases

eggNOGiKOG0084. Eukaryota.
ENOG410XQN5. LUCA.
GeneTreeiENSGT00840000129698.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ5ZHV1.
KOiK07920.
OMAiPAWIEEC.
OrthoDBiEOG78PVB5.
PhylomeDBiQ5ZHV1.
TreeFamiTF300097.

Enzyme and pathway databases

ReactomeiR-GGA-6811438. Intra-Golgi traffic.

Miscellaneous databases

PROiQ5ZHV1.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiRB33B_CHICK
AccessioniPrimary (citable) accession number: Q5ZHV1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 23, 2004
Last modified: June 8, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.