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Protein

Elongator complex protein 3

Gene

ELP3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling. Involved in acetylation of alpha-tubulin (By similarity). May also have a methyltransferase activity (By similarity).By similarity

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.

Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi98Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1
Metal bindingi108Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1
Metal bindingi111Iron-sulfur (4Fe-4S-S-AdoMet)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processTranscription, Transcription regulation
LigandIron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Elongator complex protein 3 (EC:2.3.1.48)
Gene namesi
Name:ELP3
ORF Names:RCJMB04_33o1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002839881 – 546Elongator complex protein 3Add BLAST546

Proteomic databases

PaxDbiQ5ZHS1

Expressioni

Gene expression databases

BgeeiENSGALG00000016624

Interactioni

Subunit structurei

Component of the RNA polymerase II elongator complex (Elongator). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000008425

Structurei

3D structure databases

ProteinModelPortaliQ5ZHS1
SMRiQ5ZHS1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini395 – 546N-acetyltransferasePROSITE-ProRule annotationAdd BLAST152

Sequence similaritiesi

Belongs to the ELP3 family.Curated

Phylogenomic databases

eggNOGiKOG2535 Eukaryota
COG1243 LUCA
HOGENOMiHOG000227514
HOVERGENiHBG107845
InParanoidiQ5ZHS1
KOiK07739
OrthoDBiEOG091G03ZS
PhylomeDBiQ5ZHS1

Family and domain databases

Gene3Di3.80.30.20, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR034687 ELP3-like
IPR006638 Elp3/MiaB/NifB
IPR000182 GNAT_dom
IPR032432 Radical_SAM_C
IPR007197 rSAM
IPR023404 rSAM_horseshoe
PANTHERiPTHR11135:SF0 PTHR11135:SF0, 1 hit
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 1 hit
PF04055 Radical_SAM, 1 hit
PF16199 Radical_SAM_C, 1 hit
PIRSFiPIRSF005669 Hist_AcTrfase_ELP3, 1 hit
SFLDiSFLDF00344 ELP3-like, 1 hit
SMARTiView protein in SMART
SM00729 Elp3, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
TIGRFAMsiTIGR01211 ELP3, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q5ZHS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQKRKDLSH AELMMMTIAD IIKQLIEAHE QGKDVNLNKL KTKTSAKYGL
60 70 80 90 100
SAQPRLVDII AAVPPQHRKA LVPKLKAKPI RTASGIAVVA VMCKPHRCPH
110 120 130 140 150
INFTGNICVY CPGGPDSDFE YSTQSYTGYE PTSMRAIRAR YDPYLQTRHR
160 170 180 190 200
VEQLKQLGHS VDKVEFIVMG GTFMALPEDY RDYFIRNLHD ALSGHTSNNV
210 220 230 240 250
AEAVKYSERS LTKCVGITIE TRPDYCLKRH LSDMLSYGCT RLEIGVQSVY
260 270 280 290 300
EDVARDTNRG HTVKAVCESF HLAKDAGFKV VAHMMPDLPN MGLERDTDQF
310 320 330 340 350
VEFFENPAFR PDGMKLYPTL VIRGTGLYEL WKTGRYKSYP PSTLVDLVAR
360 370 380 390 400
ILALVPPWTR VYRVQRDIPM PLVSSGVEHG NLRELALARM KDLGTQCRDV
410 420 430 440 450
RTREVGIQEI HHKVRPYQIE LIRRDYVANG GWETFLSYED PEQDILVGLL
460 470 480 490 500
RLRKCSEESF RPELKGGVSI VRELHVYGSV VPVSSRDPSK FQHQGFGMLL
510 520 530 540
MEEAERIAKE EHGSWKIAVI SGVGTRNYYR KIGYELEGPY MVKRLQ
Length:546
Mass (Da):62,092
Last modified:November 23, 2004 - v1
Checksum:i5CF3764F583E1E0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ721063 mRNA Translation: CAG32722.1
RefSeqiNP_001034382.1, NM_001039293.1
UniGeneiGga.2688

Genome annotation databases

GeneIDi422021
KEGGigga:422021

Similar proteinsi

Entry informationi

Entry nameiELP3_CHICK
AccessioniPrimary (citable) accession number: Q5ZHS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 23, 2004
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health