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Q5ZHS1

- ELP3_CHICK

UniProt

Q5ZHS1 - ELP3_CHICK

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Protein

Elongator complex protein 3

Gene

ELP3

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling. May also have a methyltransferase activity (By similarity).By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi98 – 981Iron-sulfur (4Fe-4S-S-AdoMet)By similarity
Metal bindingi108 – 1081Iron-sulfur (4Fe-4S-S-AdoMet)By similarity
Metal bindingi111 – 1111Iron-sulfur (4Fe-4S-S-AdoMet)By similarity

GO - Molecular functioni

  1. DNA binding Source: Ensembl
  2. histone acetyltransferase activity Source: UniProtKB-EC
  3. iron-sulfur cluster binding Source: UniProtKB-KW
  4. metal ion binding Source: UniProtKB-KW
  5. phosphorylase kinase regulator activity Source: UniProtKB

GO - Biological processi

  1. positive regulation of cell migration Source: Ensembl
  2. regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  3. transcription elongation from RNA polymerase II promoter Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

ReactomeiREACT_197820. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongator complex protein 3 (EC:2.3.1.48)
Gene namesi
Name:ELP3
ORF Names:RCJMB04_33o1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. DNA-directed RNA polymerase II, holoenzyme Source: Ensembl
  3. Elongator holoenzyme complex Source: Ensembl
  4. nucleolus Source: Ensembl
  5. transcription elongation factor complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 546546Elongator complex protein 3PRO_0000283988Add
BLAST

Proteomic databases

PaxDbiQ5ZHS1.

Interactioni

Subunit structurei

Component of the RNA polymerase II elongator complex (Elongator). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit (By similarity).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000008425.

Structurei

3D structure databases

ProteinModelPortaliQ5ZHS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini395 – 546152N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ELP3 family.Curated
Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1243.
HOGENOMiHOG000227514.
HOVERGENiHBG107845.
InParanoidiQ5ZHS1.
KOiK07739.
OrthoDBiEOG7V765W.
PhylomeDBiQ5ZHS1.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
3.80.30.20. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR006638. Elp3/MiaB/NifB.
IPR000182. GNAT_dom.
IPR005910. Hist_AcTrfase_ELP3.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view]
PIRSFiPIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR01211. ELP3. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZHS1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGQKRKDLSH AELMMMTIAD IIKQLIEAHE QGKDVNLNKL KTKTSAKYGL
60 70 80 90 100
SAQPRLVDII AAVPPQHRKA LVPKLKAKPI RTASGIAVVA VMCKPHRCPH
110 120 130 140 150
INFTGNICVY CPGGPDSDFE YSTQSYTGYE PTSMRAIRAR YDPYLQTRHR
160 170 180 190 200
VEQLKQLGHS VDKVEFIVMG GTFMALPEDY RDYFIRNLHD ALSGHTSNNV
210 220 230 240 250
AEAVKYSERS LTKCVGITIE TRPDYCLKRH LSDMLSYGCT RLEIGVQSVY
260 270 280 290 300
EDVARDTNRG HTVKAVCESF HLAKDAGFKV VAHMMPDLPN MGLERDTDQF
310 320 330 340 350
VEFFENPAFR PDGMKLYPTL VIRGTGLYEL WKTGRYKSYP PSTLVDLVAR
360 370 380 390 400
ILALVPPWTR VYRVQRDIPM PLVSSGVEHG NLRELALARM KDLGTQCRDV
410 420 430 440 450
RTREVGIQEI HHKVRPYQIE LIRRDYVANG GWETFLSYED PEQDILVGLL
460 470 480 490 500
RLRKCSEESF RPELKGGVSI VRELHVYGSV VPVSSRDPSK FQHQGFGMLL
510 520 530 540
MEEAERIAKE EHGSWKIAVI SGVGTRNYYR KIGYELEGPY MVKRLQ
Length:546
Mass (Da):62,092
Last modified:November 23, 2004 - v1
Checksum:i5CF3764F583E1E0B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ721063 mRNA. Translation: CAG32722.1.
RefSeqiNP_001034382.1. NM_001039293.1.
UniGeneiGga.2688.

Genome annotation databases

GeneIDi422021.
KEGGigga:422021.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ721063 mRNA. Translation: CAG32722.1 .
RefSeqi NP_001034382.1. NM_001039293.1.
UniGenei Gga.2688.

3D structure databases

ProteinModelPortali Q5ZHS1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000008425.

Proteomic databases

PaxDbi Q5ZHS1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 422021.
KEGGi gga:422021.

Organism-specific databases

CTDi 55140.

Phylogenomic databases

eggNOGi COG1243.
HOGENOMi HOG000227514.
HOVERGENi HBG107845.
InParanoidi Q5ZHS1.
KOi K07739.
OrthoDBi EOG7V765W.
PhylomeDBi Q5ZHS1.

Enzyme and pathway databases

Reactomei REACT_197820. HATs acetylate histones.

Miscellaneous databases

NextBioi 20824710.
PROi Q5ZHS1.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
3.80.30.20. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR006638. Elp3/MiaB/NifB.
IPR000182. GNAT_dom.
IPR005910. Hist_AcTrfase_ELP3.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
[Graphical view ]
Pfami PF00583. Acetyltransf_1. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view ]
PIRSFi PIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
SMARTi SM00729. Elp3. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
TIGRFAMsi TIGR01211. ELP3. 1 hit.
PROSITEi PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CB.
    Tissue: Bursa of Fabricius.

Entry informationi

Entry nameiELP3_CHICK
AccessioniPrimary (citable) accession number: Q5ZHS1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 23, 2004
Last modified: November 26, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3