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Q5ZHS1 (ELP3_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Elongator complex protein 3

EC=2.3.1.48
Gene names
Name:ELP3
ORF Names:RCJMB04_33o1
OrganismGallus gallus (Chicken) [Reference proteome]
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus

Protein attributes

Sequence length546 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling. May also have a methyltransferase activity By similarity.

Catalytic activity

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Cofactor

Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.

Subunit structure

Component of the RNA polymerase II elongator complex (Elongator). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the ELP3 family.

Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandIron
Iron-sulfur
Metal-binding
S-adenosyl-L-methionine
   Molecular functionAcyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of protein kinase activity

Inferred from sequence or structural similarity. Source: GOC

regulation of transcription from RNA polymerase II promoter

Inferred from sequence or structural similarity. Source: UniProtKB

transcription elongation from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentDNA-directed RNA polymerase II, holoenzyme

Inferred from electronic annotation. Source: Ensembl

Elongator holoenzyme complex

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

nucleolus

Inferred from electronic annotation. Source: Ensembl

transcription elongation factor complex

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: Ensembl

histone acetyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

iron-sulfur cluster binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphorylase kinase regulator activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 546546Elongator complex protein 3
PRO_0000283988

Regions

Domain395 – 546152N-acetyltransferase

Sites

Metal binding981Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Metal binding1081Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Metal binding1111Iron-sulfur (4Fe-4S-S-AdoMet) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5ZHS1 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 5CF3764F583E1E0B

FASTA54662,092
        10         20         30         40         50         60 
MGQKRKDLSH AELMMMTIAD IIKQLIEAHE QGKDVNLNKL KTKTSAKYGL SAQPRLVDII 

        70         80         90        100        110        120 
AAVPPQHRKA LVPKLKAKPI RTASGIAVVA VMCKPHRCPH INFTGNICVY CPGGPDSDFE 

       130        140        150        160        170        180 
YSTQSYTGYE PTSMRAIRAR YDPYLQTRHR VEQLKQLGHS VDKVEFIVMG GTFMALPEDY 

       190        200        210        220        230        240 
RDYFIRNLHD ALSGHTSNNV AEAVKYSERS LTKCVGITIE TRPDYCLKRH LSDMLSYGCT 

       250        260        270        280        290        300 
RLEIGVQSVY EDVARDTNRG HTVKAVCESF HLAKDAGFKV VAHMMPDLPN MGLERDTDQF 

       310        320        330        340        350        360 
VEFFENPAFR PDGMKLYPTL VIRGTGLYEL WKTGRYKSYP PSTLVDLVAR ILALVPPWTR 

       370        380        390        400        410        420 
VYRVQRDIPM PLVSSGVEHG NLRELALARM KDLGTQCRDV RTREVGIQEI HHKVRPYQIE 

       430        440        450        460        470        480 
LIRRDYVANG GWETFLSYED PEQDILVGLL RLRKCSEESF RPELKGGVSI VRELHVYGSV 

       490        500        510        520        530        540 
VPVSSRDPSK FQHQGFGMLL MEEAERIAKE EHGSWKIAVI SGVGTRNYYR KIGYELEGPY 


MVKRLQ 

« Hide

References

[1]"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis."
Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M.
Genome Biol. 6:R6.1-R6.9(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: CB.
Tissue: Bursa of Fabricius.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ721063 mRNA. Translation: CAG32722.1.
RefSeqNP_001034382.1. NM_001039293.1.
UniGeneGga.2688.

3D structure databases

ProteinModelPortalQ5ZHS1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9031.ENSGALP00000008425.

Proteomic databases

PaxDbQ5ZHS1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID422021.
KEGGgga:422021.

Organism-specific databases

CTD55140.

Phylogenomic databases

eggNOGCOG1243.
HOGENOMHOG000227514.
HOVERGENHBG107845.
KOK07739.
OrthoDBEOG7V765W.
PhylomeDBQ5ZHS1.

Family and domain databases

Gene3D3.40.630.30. 1 hit.
3.80.30.20. 1 hit.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR006638. Elp3/MiaB/NifB.
IPR000182. GNAT_dom.
IPR005910. Hist_AcTrfase_ELP3.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
[Graphical view]
PfamPF00583. Acetyltransf_1. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view]
PIRSFPIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
SMARTSM00729. Elp3. 1 hit.
[Graphical view]
SUPFAMSSF55729. SSF55729. 1 hit.
TIGRFAMsTIGR01211. ELP3. 1 hit.
PROSITEPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20824710.
PROQ5ZHS1.

Entry information

Entry nameELP3_CHICK
AccessionPrimary (citable) accession number: Q5ZHS1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families