Reviewed, UniProtKB/Swiss-Prot Q5ZHS1 (ELP3_CHICK)

Names and origin

Protein names

Recommended name:
    Elongator complex protein 3
    EC=2.3.1.48

Gene names

Name:	ELP3
ORF Names:	RCJMB04_33o1

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	546 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling. May also have a methyltransferase activity By similarity.
Catalytic activity	Acetyl-CoA + histone = CoA + acetylhistone.
Cofactor	Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.
Subunit structure	Component of the RNA polymerase II elongator complex (Elongator). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the ELP3 family. Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	Iron Iron-sulfur Metal-binding S-adenosyl-L-methionine
Molecular function	Acyltransferase Transferase
Gene Ontology (GO)
Biological process	regulation of transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: UniProtKB transcription Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB transcription elongation factor complex Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	histone acetyltransferase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW iron-sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW phosphorylase kinase regulator activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 546	546	Elongator complex protein 3		PRO_0000283988
Regions
	Domain	395 – 546	152	N-acetyltransferase
Sites
	Metal binding	98	1	Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
	Metal binding	108	1	Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
	Metal binding	111	1	Iron-sulfur (4Fe-4S-S-AdoMet) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5ZHS1-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 5CF3764F583E1E0B	FASTA	546	62,092
	10 20 30 40 50 60 MGQKRKDLSH AELMMMTIAD IIKQLIEAHE QGKDVNLNKL KTKTSAKYGL SAQPRLVDII 70 80 90 100 110 120 AAVPPQHRKA LVPKLKAKPI RTASGIAVVA VMCKPHRCPH INFTGNICVY CPGGPDSDFE 130 140 150 160 170 180 YSTQSYTGYE PTSMRAIRAR YDPYLQTRHR VEQLKQLGHS VDKVEFIVMG GTFMALPEDY 190 200 210 220 230 240 RDYFIRNLHD ALSGHTSNNV AEAVKYSERS LTKCVGITIE TRPDYCLKRH LSDMLSYGCT 250 260 270 280 290 300 RLEIGVQSVY EDVARDTNRG HTVKAVCESF HLAKDAGFKV VAHMMPDLPN MGLERDTDQF 310 320 330 340 350 360 VEFFENPAFR PDGMKLYPTL VIRGTGLYEL WKTGRYKSYP PSTLVDLVAR ILALVPPWTR 370 380 390 400 410 420 VYRVQRDIPM PLVSSGVEHG NLRELALARM KDLGTQCRDV RTREVGIQEI HHKVRPYQIE 430 440 450 460 470 480 LIRRDYVANG GWETFLSYED PEQDILVGLL RLRKCSEESF RPELKGGVSI VRELHVYGSV 490 500 510 520 530 540 VPVSSRDPSK FQHQGFGMLL MEEAERIAKE EHGSWKIAVI SGVGTRNYYR KIGYELEGPY MVKRLQ

References

[1]

"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis." Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M. Genome Biol. 6:RESEARCH006.1-RESEARCH006.9(2005) [PubMed: 15642098] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: CB. Tissue: Bursa of Fabricius.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ721063 mRNA. Translation: CAG32722.1.
IPI	IPI00600339.
RefSeq	NP_001034382.1.
UniGene	Gga.2688
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q5ZHS1.
Genome annotation databases
Ensembl	ENSGALT00000008439; ENSGALP00000008425; ENSGALG00000016624; Gallus gallus. [Genome view] ENSGALT00000026832; ENSGALP00000026781; ENSGALG00000016624; Gallus gallus. [Genome view]
GeneID	422021.
KEGG	gga:422021.
Organism-specific databases
CTD	422021.
Phylogenomic databases
HOVERGEN	Q5ZHS1.
Enzyme and pathway databases
BRENDA	2.3.1.48. 4.
Family and domain databases
InterPro	IPR006638. Elp3/MiaB/NifB. IPR000182. GCN5-rel_AcTrfase. IPR005910. Hist_AcTrfase_ELP3. IPR007197. Radical_SAM. [Graphical view]
Pfam	PF00583. Acetyltransf_1. 1 hit. PF04055. Radical_SAM. 1 hit. [Graphical view]
PIRSF	PIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
SMART	SM00729. Elp3. 1 hit. [Graphical view]
TIGRFAMs	TIGR01211. ELP3. 1 hit.
PROSITE	PS51186. GNAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ELP3_CHICK

Accession

Primary (citable) accession number: Q5ZHS1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	November 23, 2004
Last modified:	September 1, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)