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Protein

Small ubiquitin-related modifier 3

Gene

SUMO3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Small ubiquitin-related modifier 3Curated
Short name:
SUMO-3Curated
Gene namesi
Name:SUMO3Curated
ORF Names:RCJMB04_34j10Imported
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002676281 – 92Small ubiquitin-related modifier 3Add BLAST92
PropeptideiPRO_000026762993 – 94By similarity2

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linki92Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)PROSITE-ProRule annotation

Post-translational modificationi

Polymeric chains can be formed through Lys-11 cross-linking.By similarity
Cleavage of precursor form by a sentrin-specific protease is necessary for function.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ5ZHQ1.
PRIDEiQ5ZHQ1.

Expressioni

Gene expression databases

BgeeiENSGALG00000020973.

Interactioni

Subunit structurei

Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins (By similarity).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000033053.

Structurei

3D structure databases

ProteinModelPortaliQ5ZHQ1.
SMRiQ5ZHQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 92Ubiquitin-likePROSITE-ProRule annotationAdd BLAST78

Sequence similaritiesi

Belongs to the ubiquitin family. SUMO subfamily.Curated

Phylogenomic databases

eggNOGiKOG1769. Eukaryota.
COG5227. LUCA.
HOGENOMiHOG000207495.
HOVERGENiHBG053025.
InParanoidiQ5ZHQ1.
KOiK12160.
OMAiGAFCERQ.
OrthoDBiEOG091G10ZQ.
PhylomeDBiQ5ZHQ1.
TreeFamiTF315116.

Family and domain databases

CDDicd01763. Sumo. 1 hit.
InterProiView protein in InterPro
IPR022617. Rad60/SUMO-like_dom.
IPR033950. Sumo.
IPR027218. SUMO_2/3.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
PANTHERiPTHR10562:SF33. PTHR10562:SF33. 1 hit.
PfamiView protein in Pfam
PF11976. Rad60-SLD. 1 hit.
SMARTiView protein in SMART
SM00213. UBQ. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS50053. UBIQUITIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ZHQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEEKPKEGV KTENDHINLK VAGQDGSVVQ FKIKRHTPLS KLMKAYCERQ
60 70 80 90
GLSMRQIRFR FDGQPINEAD TPAQLEMEDE DTIDVFQQQT GGLC
Length:94
Mass (Da):10,711
Last modified:November 23, 2004 - v1
Checksum:iD878493AB123B53E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ721083 mRNA. Translation: CAG32742.1.
RefSeqiNP_001072966.1. NM_001079498.1.
UniGeneiGga.4495.

Genome annotation databases

GeneIDi770553.
KEGGigga:770553.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ721083 mRNA. Translation: CAG32742.1.
RefSeqiNP_001072966.1. NM_001079498.1.
UniGeneiGga.4495.

3D structure databases

ProteinModelPortaliQ5ZHQ1.
SMRiQ5ZHQ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000033053.

Proteomic databases

PaxDbiQ5ZHQ1.
PRIDEiQ5ZHQ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi770553.
KEGGigga:770553.

Organism-specific databases

CTDi6612.

Phylogenomic databases

eggNOGiKOG1769. Eukaryota.
COG5227. LUCA.
HOGENOMiHOG000207495.
HOVERGENiHBG053025.
InParanoidiQ5ZHQ1.
KOiK12160.
OMAiGAFCERQ.
OrthoDBiEOG091G10ZQ.
PhylomeDBiQ5ZHQ1.
TreeFamiTF315116.

Miscellaneous databases

PROiQ5ZHQ1.

Gene expression databases

BgeeiENSGALG00000020973.

Family and domain databases

CDDicd01763. Sumo. 1 hit.
InterProiView protein in InterPro
IPR022617. Rad60/SUMO-like_dom.
IPR033950. Sumo.
IPR027218. SUMO_2/3.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
PANTHERiPTHR10562:SF33. PTHR10562:SF33. 1 hit.
PfamiView protein in Pfam
PF11976. Rad60-SLD. 1 hit.
SMARTiView protein in SMART
SM00213. UBQ. 1 hit.
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS50053. UBIQUITIN_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSUMO3_CHICK
AccessioniPrimary (citable) accession number: Q5ZHQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 23, 2004
Last modified: March 15, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.