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Protein

Small ubiquitin-related modifier 3

Gene

SUMO3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Small ubiquitin-related modifier 3Curated
Short name:
SUMO-3Curated
Gene namesi
Name:SUMO3Curated
ORF Names:RCJMB04_34j10Imported
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002676281 – 92Small ubiquitin-related modifier 3Add BLAST92
PropeptideiPRO_000026762993 – 94By similarity2

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki11Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)By similarity
Cross-linki92Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)PROSITE-ProRule annotation

Post-translational modificationi

Polymeric chains can be formed through Lys-11 cross-linking.By similarity
Cleavage of precursor form by a sentrin-specific protease is necessary for function.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ5ZHQ1
PRIDEiQ5ZHQ1

Expressioni

Gene expression databases

BgeeiENSGALG00000020973

Interactioni

Subunit structurei

Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins (By similarity).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000033053

Structurei

3D structure databases

ProteinModelPortaliQ5ZHQ1
SMRiQ5ZHQ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 92Ubiquitin-likePROSITE-ProRule annotationAdd BLAST78

Sequence similaritiesi

Belongs to the ubiquitin family. SUMO subfamily.Curated

Phylogenomic databases

eggNOGiKOG1769 Eukaryota
COG5227 LUCA
HOGENOMiHOG000207495
HOVERGENiHBG053025
InParanoidiQ5ZHQ1
KOiK12160
OMAiRFRFDGH
OrthoDBiEOG091G10ZQ
PhylomeDBiQ5ZHQ1
TreeFamiTF315116

Family and domain databases

CDDicd01763 Sumo, 1 hit
InterProiView protein in InterPro
IPR022617 Rad60/SUMO-like_dom
IPR033950 Sumo
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF11976 Rad60-SLD, 1 hit
SMARTiView protein in SMART
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ZHQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEEKPKEGV KTENDHINLK VAGQDGSVVQ FKIKRHTPLS KLMKAYCERQ
60 70 80 90
GLSMRQIRFR FDGQPINEAD TPAQLEMEDE DTIDVFQQQT GGLC
Length:94
Mass (Da):10,711
Last modified:November 23, 2004 - v1
Checksum:iD878493AB123B53E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ721083 mRNA Translation: CAG32742.1
RefSeqiNP_001072966.1, NM_001079498.1
UniGeneiGga.4495

Genome annotation databases

GeneIDi770553
KEGGigga:770553

Similar proteinsi

Entry informationi

Entry nameiSUMO3_CHICK
AccessioniPrimary (citable) accession number: Q5ZHQ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 23, 2004
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health