Q5ZHN9 (PGPS1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial
EC=2.7.8.5

Alternative name(s):
Phosphatidylglycerophosphate synthase 1
Short name=PGP synthase 1

Gene names

Name:	PGS1
ORF Names:	RCJMB04_35a14

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	557 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin By similarity.
Catalytic activity	CDP-diacylglycerol + sn-glycerol 3-phosphate = CMP + 3(3-sn-phosphatidyl)-sn-glycerol 1-phosphate.
Enzyme regulation	Activated by calcium and magnesium and inhibited by other bivalent cations By similarity.
Pathway	Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the CDP-alcohol phosphatidyltransferase class-II family. Contains 2 PLD phosphodiesterase domains.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Mitochondrion
Domain	Repeat Transit peptide
Ligand	ATP-binding Nucleotide-binding
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 25	25	Mitochondrion Potential
	Chain	26 – 557	532	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial		PRO_0000337109
Regions
	Domain	212 – 238	27	PLD phosphodiesterase 1
	Domain	461 – 494	34	PLD phosphodiesterase 2
	Nucleotide binding	121 – 128	8	ATP Potential
Sites
	Active site	217	1	Potential
	Active site	219	1	Potential
	Active site	224	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5ZHN9 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 40296640BBAB1B7F	FASTA	557	63,067
	10 20 30 40 50 60 MAAAGGAALW RRLAAWLPRG PPGLAALLGR LSDRLSRGRD RRSRRSSWLL LAPLLTPPVP 70 80 90 100 110 120 VITAMPCSLC PEGAHRFQWI RNLVPEFGIS SSHVKVLSSP AEFYELLKVQ IKTAKQRVVM 130 140 150 160 170 180 ASLYLGTGLL EQELVNCLEE TLEKSLQANE SPNLRVSILL DYTRGSRGRK NSRTMLIPLL 190 200 210 220 230 240 QRFPEQVRVS LFHTPNLRGL LKLLIPERFN ETIGLQHIKV YLFDDNVILS GANLSDLYFT 250 260 270 280 290 300 NRQDRYVLLQ DSPEIADFFT ELVDAIGDVS LQLQQDDTVQ MMEGMVHPYQ GDKVRYCEIA 310 320 330 340 350 360 NQRVMEVIDS ARTRQELLHA KTFHSSQQGS SMLPQHDSEA SEGLKPEPDT WIYPLIQMKP 370 380 390 400 410 420 FGIQIDEMVT ETLLTEAERD AKIYLTTGYF NLTQAYMDLI LGTRAEYRIL LASPEVNGFF 430 440 450 460 470 480 GAKGVAGAIP SAYVYIEHQF YNEVCCLHQQ ERVQLQEYSR AGWTFHAKGL WLYLAGSSLP 490 500 510 520 530 540 CLTLIGSPNF GYRSVHRDLE AQVAIVTENK ALQQQLHQEQ EQLYLCSGVV SSSTFEQPSR 550 HVKLWVKLVT PLIKNFF

References

[1]

"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis." Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P., Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P., Hayashizaki Y., Buerstedde J.-M. Genome Biol. 6:R6.1-R6.9(2005) [PubMed: 15642098] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: CB. Tissue: Bursa of Fabricius.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ721095 mRNA. Translation: CAG32754.1.
IPI	IPI00586398.
RefSeq	NP_001008463.1. NM_001008463.1.
UniGene	Gga.22573.
3D structure databases
ProteinModelPortal	Q5ZHN9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5ZHN9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSGALT00000011630; ENSGALP00000011616; ENSGALG00000007181.
GeneID	422087.
KEGG	gga:422087.
Organism-specific databases
CTD	9489.
Phylogenomic databases
eggNOG	veNOG13078.
GeneTree	ENSGT00390000002373.
HOGENOM	HBG737293.
HOVERGEN	HBG057228.
InParanoid	Q5ZHN9.
OMA	RQDRYVL.
OrthoDB	EOG4HDSTM.
PhylomeDB	Q5ZHN9.
Family and domain databases
InterPro	IPR016270. PLipase-D_PtdSer-synthase-type. IPR001736. PLipase_D/transphosphatidylase. [Graphical view]
KO	K00995.
PANTHER	PTHR12586. PTHR12586. 1 hit.
PIRSF	PIRSF000850. Phospholipase_D_PSS. 1 hit.
PROSITE	PS50035. PLD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGPS1_CHICK

Accession

Primary (citable) accession number: Q5ZHN9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	November 23, 2004
Last modified:	November 16, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program