Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

WD repeat domain phosphoinositide-interacting protein 2

Gene

WIPI2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to phosphatidylinositol 3-phosphate (PtdIns3P). Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Omegasomes are derived from ER and serve as intermediates for genesis of isolation membrane (also called preautophagosome) from ER cisternae membranes.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAutophagy

Enzyme and pathway databases

ReactomeiR-GGA-1632852. Macroautophagy.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat domain phosphoinositide-interacting protein 2
Short name:
WIPI-2
Gene namesi
Name:WIPI2
ORF Names:RCJMB04_35d18
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000514431 – 436WD repeat domain phosphoinositide-interacting protein 2Add BLAST436

Proteomic databases

PaxDbiQ5ZHN3.

Expressioni

Gene expression databases

BgeeiENSGALG00000004557.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000007240.

Structurei

3D structure databases

ProteinModelPortaliQ5ZHN3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati182 – 222WD 1Sequence analysisAdd BLAST41
Repeati228 – 267WD 2Sequence analysisAdd BLAST40
Repeati311 – 349WD 3Sequence analysisAdd BLAST39

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi223 – 226FRRG motifBy similarity4

Domaini

The FRRG motif is required for recruitment to PtdIns3P.

Sequence similaritiesi

Belongs to the WD repeat SVP1 family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2110. Eukaryota.
ENOG410XP6Y. LUCA.
GeneTreeiENSGT00730000110845.
HOGENOMiHOG000217544.
HOVERGENiHBG056639.
InParanoidiQ5ZHN3.
KOiK17908.
OMAiWEPSRDF.
OrthoDBiEOG091G08ZS.
PhylomeDBiQ5ZHN3.
TreeFamiTF314879.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR036322. WD40_repeat_dom_sf.
IPR032911. WIPI2.
PANTHERiPTHR11227:SF27. PTHR11227:SF27. 1 hit.
SMARTiView protein in SMART
SM00320. WD40. 3 hits.
SUPFAMiSSF50978. SSF50978. 2 hits.

Sequencei

Sequence statusi: Complete.

Q5ZHN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLAGQSGDA GSGHLLFANF NQDNTSLAVG SKSGYKFFSL SSVDKLEQIY
60 70 80 90 100
ECTDTEDVCI VERLFSSSLV AIVSLKAPRK LKVCHFKKGT EICNYSYSNT
110 120 130 140 150
ILAVKLNRQR LIVCLEESLY IHNIRDMKVL HTIRETPPNP AGLCALSINN
160 170 180 190 200
DNCYLAYPGS ATIGEVQVFD TINLRAANMI PAHDSPLAAL AFDASGTKLA
210 220 230 240 250
TASEKGTVIR VFSIPEGQKL FEFRRGVKRC VSICSLAFSM DGMFLSASSN
260 270 280 290 300
TETVHIFKLE TVKEKPQEEP TTWTGYFGKV LMASTSYLPS QVTEMFNQGR
310 320 330 340 350
AFATVRLPFC GHKNICALAT IQKIPRLLVG AADGYLYMYN LDPQEGGECT
360 370 380 390 400
LMKQHKLDGS MEPANEILES ASHDRPLVAQ TYSAAVTKGT YVPSSPTRHA
410 420 430
YTEDLGAVGG ACLEDETNSL RLDEDSEHPP MILRTD
Length:436
Mass (Da):47,775
Last modified:November 23, 2004 - v1
Checksum:i8848FD63D5C49EE6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ721101 mRNA. Translation: CAG32760.1.
RefSeqiNP_001006162.1. NM_001006162.1.
UniGeneiGga.17346.

Genome annotation databases

EnsembliENSGALT00000007252; ENSGALP00000007240; ENSGALG00000004557.
GeneIDi416481.
KEGGigga:416481.

Similar proteinsi

Entry informationi

Entry nameiWIPI2_CHICK
AccessioniPrimary (citable) accession number: Q5ZHN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: November 23, 2004
Last modified: October 25, 2017
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families