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Protein
Submitted name:

5-hydroxytryptamine (Serotonin) receptor 1A

Gene

5HT1A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
5-hydroxytryptamine (Serotonin) receptor 1AImported
Submitted name:
5-hydroxytryptamine receptor 1AImported
Gene namesi
Name:5HT1AImported
Synonyms:HTR1AImported
ORF Names:hCG_16836Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000178394.4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei41 – 63HelicalSequence analysisAdd BLAST23
Transmembranei70 – 99HelicalSequence analysisAdd BLAST30
Transmembranei111 – 132HelicalSequence analysisAdd BLAST22
Transmembranei153 – 175HelicalSequence analysisAdd BLAST23
Transmembranei195 – 218HelicalSequence analysisAdd BLAST24
Transmembranei347 – 368HelicalSequence analysisAdd BLAST22
Transmembranei380 – 403HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA192

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

MaxQBiQ5ZGX3

Expressioni

Gene expression databases

BgeeiENSG00000178394
ExpressionAtlasiQ5ZGX3 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 400G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST348

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili321 – 341Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOVERGENiHBG106962
KOiK04153
OMAiYQVLNKW
OrthoDBiEOG091G06VI

Family and domain databases

CDDicd15330 7tmA_5-HT1A_vertebrates, 1 hit
InterProiView protein in InterPro
IPR000610 5HT1A_rcpt
IPR002231 5HT_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24247:SF20 PTHR24247:SF20, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00512 5HT1ARECEPTR
PR01101 5HTRECEPTOR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5ZGX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVLSPGQGN NTTSPPAPFE TGGNTTGISD VTVSYQVITS LLLGTLIFCA
60 70 80 90 100
VLGNACVVAA IALERSLQNV ANYLIGSLAV TDLMVSVLVL PMAALYQVLN
110 120 130 140 150
KWTLGQVTCD LFIALDVLCC TSSILHLCAI ALDRYWAITD PIDYVNKRTP
160 170 180 190 200
RRAAALISLT WLIGFLISIP PMLGWRTPED RSDPDACTIS KDHGYTIYST
210 220 230 240 250
FGAFYIPLLL MLVLYGRIFR AARFRIRKTV KKVEKTGADT RHGASPAPQP
260 270 280 290 300
KKSVNGESGS RNWRLGVESK AGGALCANGA VRQGDDGAAL EVIEVHRVGN
310 320 330 340 350
SKEHLPLPSE AGPTPCAPAS FERKNERNAE AKRKMALARE RKTVKTLGII
360 370 380 390 400
MGTFILCWLP FFIVALVLPF CESSCHMPTL LGAIINWLGY SNSLLNPVIY
410 420
AYFNKDFQNA FKKIIKCKFC RQ
Length:422
Mass (Da):46,107
Last modified:May 10, 2005 - v1
Checksum:i762664FCF62CFD8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC136263 mRNA Translation: AAI36264.1
AJ781317 Genomic DNA Translation: CAH03197.1
CH471137 Genomic DNA Translation: EAW51377.1
RefSeqiNP_000515.2, NM_000524.3
UniGeneiHs.247940

Genome annotation databases

GeneIDi3350
KEGGihsa:3350
UCSCiuc011cqt.4 human

Similar proteinsi

Entry informationi

Entry nameiQ5ZGX3_HUMAN
AccessioniPrimary (citable) accession number: Q5ZGX3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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