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Q5ZCI1

- MPK10_ORYSJ

UniProt

Q5ZCI1 - MPK10_ORYSJ

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Protein

Mitogen-activated protein kinase 10

Gene

MPK10

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei54 – 541ATPPROSITE-ProRule annotation
Active sitei151 – 1511Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi31 – 399ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 10 (EC:2.7.11.24)
Short name:
MAP kinase 10
Gene namesi
Name:MPK10
Ordered Locus Names:Os01g0629900, LOC_Os01g43910
ORF Names:OSJNBb0035I14.5-1, OSJNBb0035I14.5-2, OSJNBb0035I14.5-3
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 1

Organism-specific databases

GrameneiQ5ZCI1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 611611Mitogen-activated protein kinase 10PRO_0000239753Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei187 – 1871PhosphothreonineBy similarity
Modified residuei189 – 1891PhosphotyrosineBy similarity

Post-translational modificationi

Dually phosphorylated on Thr-187 and Tyr-189, which activates the enzyme.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ5ZCI1.

Expressioni

Gene expression databases

ExpressionAtlasiQ5ZCI1. baseline.

Structurei

3D structure databases

ProteinModelPortaliQ5ZCI1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 316292Protein kinasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi187 – 1893TXY

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiQ5ZCI1.
OMAiSQAERYT.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5ZCI1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQQDQRKKSS TEADFFTEYG DASRYKIQEV IGKGSYGVVC SAIDVHTGEK
60 70 80 90 100
VAIKKIHDIF EHISDAARIL REIKLLRLLR HPDIVEIKHI MLPPSRRDFK
110 120 130 140 150
DIYVVFELME SDLHQVIKAN DDLTKEHYQF FLYQLLRALK YIHTANVYHR
160 170 180 190 200
DLKPKNILAN SNCKLKICDF GLARVAFNDT PTTIFWTDYV ATRWYRAPEL
210 220 230 240 250
CGSFFSKYTP AIDIWSIGCI FAEVLTGKPL FPGKNVVHQL DLMTDLLGTP
260 270 280 290 300
SMDTISRVRN DKARRYLSSM RKKEPILFSQ KFPSADPLAL DLLQKLLAFD
310 320 330 340 350
PKDRPTAEEA LAHPYFKGLA KVEREPSCQP ITKMEFEFER RRVTKEDIRE
360 370 380 390 400
LIFREILEYH PQLLKDYING TERTTFLYPS AVDQFRKQFA HLEENGGNGP
410 420 430 440 450
VIPMDRKHTS LPRSTIVHST PIPAKEQPRI GPSRDKPSDE PYSNPREFDR
460 470 480 490 500
FSGNAPRTSQ APQRVPTARP GRVVGPVLPY ENGATKDSYD ARRLAMNSGY
510 520 530 540 550
PPQQQIPQAY GYYQIPGKSA CSELSQAERY TLHQQAYTCA NSATVTDVAL
560 570 580 590 600
DMRAPPFHLS GGPKSDSSER LAAETNLYTR SLNGLAATAA GVAASAHRKV
610
GVVPYGMSRM Y
Length:611
Mass (Da):69,400
Last modified:June 13, 2006 - v2
Checksum:i790BC90D262BEFCD
GO

Sequence cautioni

The sequence BAD61402.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence BAD61403.1 differs from that shown. Reason: Erroneous gene model prediction.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti153 – 1531K → R(PubMed:12869764)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP003220 Genomic DNA. Translation: BAD61401.1.
AP003220 Genomic DNA. Translation: BAD61402.1. Sequence problems.
AP003220 Genomic DNA. Translation: BAD61403.1. Sequence problems.
AK065930 mRNA. No translation available.
RefSeqiNP_001043642.1. NM_001050177.1.
UniGeneiOs.26152.

Genome annotation databases

EnsemblPlantsiOS01T0629900-01; OS01T0629900-01; OS01G0629900.
GeneIDi4326668.
KEGGiosa:4326668.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP003220 Genomic DNA. Translation: BAD61401.1 .
AP003220 Genomic DNA. Translation: BAD61402.1 . Sequence problems.
AP003220 Genomic DNA. Translation: BAD61403.1 . Sequence problems.
AK065930 mRNA. No translation available.
RefSeqi NP_001043642.1. NM_001050177.1.
UniGenei Os.26152.

3D structure databases

ProteinModelPortali Q5ZCI1.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q5ZCI1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS01T0629900-01 ; OS01T0629900-01 ; OS01G0629900 .
GeneIDi 4326668.
KEGGi osa:4326668.

Organism-specific databases

Gramenei Q5ZCI1.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
InParanoidi Q5ZCI1.
OMAi SQAERYT.

Gene expression databases

ExpressionAtlasi Q5ZCI1. baseline.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence and structure of rice chromosome 1."
    Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y., Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H., Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.
    , Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M., Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T., Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S., Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H., Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y., Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S., Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y., Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S., Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H., Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.
    Nature 420:312-316(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  2. "Collection, mapping, and annotation of over 28,000 cDNA clones from japonica rice."
    The rice full-length cDNA consortium
    Science 301:376-379(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Nipponbare.
  3. "Molecular analysis of the rice MAP kinase gene family in relation to Magnaporthe grisea infection."
    Reyna N.S., Yang Y.
    Mol. Plant Microbe Interact. 19:530-540(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.

Entry informationi

Entry nameiMPK10_ORYSJ
AccessioniPrimary (citable) accession number: Q5ZCI1
Secondary accession number(s): Q5ZCI2, Q5ZCI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: October 29, 2014
This is version 59 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3