ID GUN18_ORYSJ Reviewed; 518 AA. AC Q5Z9P8; A0A0P0X0U4; Q0D9H6; DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot. DT 23-NOV-2004, sequence version 1. DT 24-JAN-2024, entry version 98. DE RecName: Full=Endoglucanase 18; DE EC=3.2.1.4; DE AltName: Full=Endo-1,4-beta glucanase 18; GN OrderedLocusNames=Os06g0715300, LOC_Os06g50140; ORFNames=P0481E08.13; OS Oryza sativa subsp. japonica (Rice). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade; OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa. OX NCBI_TaxID=39947; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Nipponbare; RX PubMed=16100779; DOI=10.1038/nature03895; RG International rice genome sequencing project (IRGSP); RT "The map-based sequence of the rice genome."; RL Nature 436:793-800(2005). RN [2] RP GENOME REANNOTATION. RC STRAIN=cv. Nipponbare; RX PubMed=18089549; DOI=10.1093/nar/gkm978; RG The rice annotation project (RAP); RT "The rice annotation project database (RAP-DB): 2008 update."; RL Nucleic Acids Res. 36:D1028-D1033(2008). RN [3] RP GENOME REANNOTATION. RC STRAIN=cv. Nipponbare; RX PubMed=24280374; DOI=10.1186/1939-8433-6-4; RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R., RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L., RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H., RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.; RT "Improvement of the Oryza sativa Nipponbare reference genome using next RT generation sequence and optical map data."; RL Rice 6:4-4(2013). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=cv. Nipponbare; RX PubMed=12869764; DOI=10.1126/science.1081288; RG The rice full-length cDNA consortium; RT "Collection, mapping, and annotation of over 28,000 cDNA clones from RT japonica rice."; RL Science 301:376-379(2003). CC -!- CATALYTIC ACTIVITY: CC Reaction=Endohydrolysis of (1->4)-beta-D-glucosidic linkages in CC cellulose, lichenin and cereal beta-D-glucans.; EC=3.2.1.4; CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein. CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 9 (cellulase E) family. CC {ECO:0000255|PROSITE-ProRule:PRU10140, ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AP003614; BAD53575.1; -; Genomic_DNA. DR EMBL; AP008212; BAF20497.1; -; Genomic_DNA. DR EMBL; AP014962; BAS99495.1; -; Genomic_DNA. DR EMBL; AK121369; -; NOT_ANNOTATED_CDS; mRNA. DR RefSeq; XP_015642677.1; XM_015787191.1. DR AlphaFoldDB; Q5Z9P8; -. DR SMR; Q5Z9P8; -. DR STRING; 39947.Q5Z9P8; -. DR CAZy; GH9; Glycoside Hydrolase Family 9. DR PaxDb; 39947-Q5Z9P8; -. DR EnsemblPlants; Os06t0715300-01; Os06t0715300-01; Os06g0715300. DR GeneID; 4342070; -. DR Gramene; Os06t0715300-01; Os06t0715300-01; Os06g0715300. DR KEGG; osa:4342070; -. DR eggNOG; ENOG502QRF6; Eukaryota. DR HOGENOM; CLU_008926_1_4_1; -. DR InParanoid; Q5Z9P8; -. DR OMA; GHKWLET; -. DR OrthoDB; 1347382at2759; -. DR Proteomes; UP000000763; Chromosome 6. DR Proteomes; UP000059680; Chromosome 6. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0008810; F:cellulase activity; IEA:UniProtKB-EC. DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW. DR GO; GO:0030245; P:cellulose catabolic process; IEA:UniProtKB-KW. DR Gene3D; 1.50.10.10; -; 1. DR InterPro; IPR008928; 6-hairpin_glycosidase_sf. DR InterPro; IPR012341; 6hp_glycosidase-like_sf. DR InterPro; IPR001701; Glyco_hydro_9. DR InterPro; IPR018221; Glyco_hydro_9_His_AS. DR PANTHER; PTHR22298; ENDO-1,4-BETA-GLUCANASE; 1. DR PANTHER; PTHR22298:SF121; ENDOGLUCANASE 18; 1. DR Pfam; PF00759; Glyco_hydro_9; 1. DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1. DR PROSITE; PS60032; GH9_1; 1. DR PROSITE; PS00592; GH9_2; 1. DR Genevisible; Q5Z9P8; OS. PE 2: Evidence at transcript level; KW Carbohydrate metabolism; Cell wall biogenesis/degradation; KW Cellulose degradation; Glycoprotein; Glycosidase; Hydrolase; Membrane; KW Polysaccharide degradation; Reference proteome; Signal-anchor; KW Transmembrane; Transmembrane helix. FT CHAIN 1..518 FT /note="Endoglucanase 18" FT /id="PRO_0000249295" FT TOPO_DOM 1..35 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 36..56 FT /note="Helical" FT /evidence="ECO:0000255" FT TOPO_DOM 57..518 FT /note="Extracellular" FT /evidence="ECO:0000255" FT ACT_SITE 101 FT /note="Nucleophile" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10140" FT ACT_SITE 436 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10059" FT ACT_SITE 482 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10059" FT ACT_SITE 491 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10059" FT CARBOHYD 71 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 214 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 251 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 272 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 477 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CONFLICT 450 FT /note="C -> Y (in Ref. 4; AK121369)" FT /evidence="ECO:0000305" SQ SEQUENCE 518 AA; 56741 MW; F6DA8EC0D7951B8C CRC64; MANCVRCCCW LLVLMLMALA ITAAVVFVRY KNGEGVFPFP GVPGAVDHKY ADALAVALQF FQVQKSGKLV NNTIHWRGDS ALDDGKEAGI DLSKGMYDAG DHMKFGFPMA FTATMLSWSV LEYGDAMRAA DQRDSAIDAL NWIMDYLVNA HPSDDVLYIQ VGDPKADHKC WERPEKMKEK RPLTKITPKS PGSDVAAETA AAMAAASLVY KTINKTYSSS LLDHGERLFA FADKHRGSYT RTFPELSAFY NSTTYQDELL WAASWLYHAT GNHSYLAYAT GKNKDFADLG NPRYFSWDDK RAGTEVLLSR VSFFASQGSD VAQDDVLGMY KQTADAVMCI LLPDSETAAF RTEGGLLYVA EWNSLQHPVA SAFLAAVYSD YMQSSGKTEL SCSGQGFSPA DLRKFAKSQA DYLLGSNPMK ISYLVGYGDR YPEKVHHRGA SIPEDVDTGC DGHKWLETSK PNPNVATGAL VGGPYKNDSF VDERDNVMQN EATTYNSALV AGLLSALVST SSLARSLS //