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Protein

Probable inositol oxygenase

Gene

Os06g0561000

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the biosynthesis of UDP-glucuronic acid (UDP-GlcA), providing nucleotide sugars for cell-wall polymers. May be also involved in plant ascorbate biosynthesis (By similarity).By similarity

Catalytic activityi

Myo-inositol + O2 = D-glucuronate + H2O.

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi: myo-inositol degradation into D-glucuronate

This protein is involved in step 1 of the subpathway that synthesizes D-glucuronate from myo-inositol.
Proteins known to be involved in this subpathway in this organism are:
  1. Probable inositol oxygenase (Os06g0561000)
This subpathway is part of the pathway myo-inositol degradation into D-glucuronate, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glucuronate from myo-inositol, the pathway myo-inositol degradation into D-glucuronate and in Polyol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei49SubstrateBy similarity1
Metal bindingi119Iron 1By similarity1
Metal bindingi144Iron 1By similarity1
Metal bindingi145Iron 1By similarity1
Metal bindingi145Iron 2By similarity1
Binding sitei148SubstrateBy similarity1
Metal bindingi217Iron 2By similarity1
Metal bindingi243Iron 2By similarity1
Metal bindingi276Iron 1By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Ascorbate biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00111; UER00527.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable inositol oxygenase (EC:1.13.99.1)
Alternative name(s):
Myo-inositol oxygenase
Short name:
MI oxygenase
Gene namesi
Ordered Locus Names:Os06g0561000, LOC_Os06g36560
ORF Names:P0456F09.5, P0528E12.30
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryza
Proteomesi
  • UP000059680 Componenti: Chromosome 6

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000791581 – 308Probable inositol oxygenaseAdd BLAST308

Proteomic databases

PaxDbiQ5Z8T3.

Expressioni

Gene expression databases

ExpressionAtlasiQ5Z8T3. baseline and differential.
GenevisibleiQ5Z8T3. OS.

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os06g36560.1.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni106 – 108Substrate bindingBy similarity3
Regioni165 – 166Substrate bindingBy similarity2
Regioni243 – 244Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the myo-inositol oxygenase family.Curated

Phylogenomic databases

eggNOGiKOG1573. Eukaryota.
ENOG410XQ4J. LUCA.
InParanoidiQ5Z8T3.
KOiK00469.
OMAiDPAPENM.
OrthoDBiEOG09360FOL.

Family and domain databases

InterProiIPR007828. Inositol_oxygenase.
[Graphical view]
PANTHERiPTHR12588. PTHR12588. 1 hit.
PfamiPF05153. MIOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5Z8T3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTITIEQPHL DAIADRKVAG GGGGDNAAEL VLDGGFVVPD SNAFGNAFRN
60 70 80 90 100
YEAESERKET VEEFYRVNHI NQTYDFVRRM REEYGRVDKT EMGIWECIEL
110 120 130 140 150
LNEFIDDSDP DLDMPQIEHL LQTAEAIRKD FPDEDWLHLT GLIHDLGKVL
160 170 180 190 200
LHPSFGELPQ WSVVGDTFPV GCAFDECNVH FKYFKENPDY LNPKLNTKFG
210 220 230 240 250
AYSEGCGLDN VLMSWGHDDY MYLVAKENKT TLPSAGLFII RYHSFYPLHK
260 270 280 290 300
HGAYMHLMND EDKENLKWLR VFNKYDLYSK SNERIDVEKV KPYYMSLIEK

YFPAKLRW
Length:308
Mass (Da):35,805
Last modified:November 23, 2004 - v1
Checksum:i7612DA5BFA7DE5FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003713 Genomic DNA. Translation: BAD53740.1.
AP003762 Genomic DNA. Translation: BAD53821.1.
AP014962 Genomic DNA. Translation: BAS98249.1.
AK068862 mRNA. No translation available.
RefSeqiXP_015643978.1. XM_015788492.1.
UniGeneiOs.6345.

Genome annotation databases

EnsemblPlantsiOS06T0561000-01; OS06T0561000-01; OS06G0561000.
GeneIDi4341305.
GrameneiOS06T0561000-01; OS06T0561000-01; OS06G0561000.
KEGGiosa:4341305.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003713 Genomic DNA. Translation: BAD53740.1.
AP003762 Genomic DNA. Translation: BAD53821.1.
AP014962 Genomic DNA. Translation: BAS98249.1.
AK068862 mRNA. No translation available.
RefSeqiXP_015643978.1. XM_015788492.1.
UniGeneiOs.6345.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os06g36560.1.

Proteomic databases

PaxDbiQ5Z8T3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOS06T0561000-01; OS06T0561000-01; OS06G0561000.
GeneIDi4341305.
GrameneiOS06T0561000-01; OS06T0561000-01; OS06G0561000.
KEGGiosa:4341305.

Phylogenomic databases

eggNOGiKOG1573. Eukaryota.
ENOG410XQ4J. LUCA.
InParanoidiQ5Z8T3.
KOiK00469.
OMAiDPAPENM.
OrthoDBiEOG09360FOL.

Enzyme and pathway databases

UniPathwayiUPA00111; UER00527.

Gene expression databases

ExpressionAtlasiQ5Z8T3. baseline and differential.
GenevisibleiQ5Z8T3. OS.

Family and domain databases

InterProiIPR007828. Inositol_oxygenase.
[Graphical view]
PANTHERiPTHR12588. PTHR12588. 1 hit.
PfamiPF05153. MIOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMIOX_ORYSJ
AccessioniPrimary (citable) accession number: Q5Z8T3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 23, 2004
Last modified: October 5, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.