Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q5Z8Q9 (PRP2A_ORYSJ) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Poly [ADP-ribose] polymerase 2-A

Short name=PARP-2-A
EC=2.4.2.30
Alternative name(s):
NAD(+) ADP-ribosyltransferase 2-A
Short name=ADPRT-2-A
Poly[ADP-ribose] synthase 2-A
Gene names
Name:PARP2-A
Ordered Locus Names:Os01g0351200, LOC_Os01g24940
ORF Names:B1051E10.55, P0463A02.25
OrganismOryza sativa subsp. japonica (Rice)
Taxonomic identifier39947 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza

Protein attributes

Sequence length660 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks By similarity.

Catalytic activity

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.

Subcellular location

Nucleus Potential.

Sequence similarities

Contains 1 PARP alpha-helical domain.

Contains 1 PARP catalytic domain.

Contains 2 SAP domains.

Sequence caution

The sequence BAD52929.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence BAD53855.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence BAF04898.2 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Cellular componentNucleus
   DomainRepeat
   LigandDNA-binding
NAD
   Molecular functionGlycosyltransferase
Transferase
   PTMADP-ribosylation
Gene Ontology (GO)
   Biological processprotein ADP-ribosylation

Inferred from electronic annotation. Source: InterPro

   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ ADP-ribosyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 660660Poly [ADP-ribose] polymerase 2-A
PRO_0000260503

Regions

Domain2 – 3635SAP 1
Domain91 – 12535SAP 2
Domain308 – 426119PARP alpha-helical
Domain434 – 660227PARP catalytic
Motif69 – 757Nuclear localization signal Potential
Compositional bias39 – 435Poly-Glu

Sequences

Sequence LengthMass (Da)Tools
Q5Z8Q9 [UniParc].

Last modified November 28, 2006. Version 2.
Checksum: 94FA8F38B72470A9

FASTA66074,297
        10         20         30         40         50         60 
MSARLRVEEL RAELQRRGLD ASGNKPVLVR RLDAAIRKEE EEEAAVSAAA KEEADAGGVV 

        70         80         90        100        110        120 
DGEGNGEDKR KRKRRGDGED VDNSESDAAK LEGMSYRELQ ALAKSRGLAA NGSKKEVIER 

       130        140        150        160        170        180 
LLCAPSDTDG GVQDKKKIAK GFADGDDRVE ECRKEKIVTA TRKGAAVLDQ HIPDHIKMTY 

       190        200        210        220        230        240 
HVLQVWFLLK GDEIYDATMN QTNVGDNNNK FYIIQALESD AGGSFMVYNR WGRVGARGQD 

       250        260        270        280        290        300 
KLHGPFSSRE QAIYEFEGKF HGKTNNHWSD RKSFECYARK YTWLEMDYGE ADRETNKKVS 

       310        320        330        340        350        360 
PSTDQIKETK LETRIASFIS LICNISMMKQ QMVEIGYNSD KLPLGKLSKS TIFKGYDVLK 

       370        380        390        400        410        420 
RISNVISRAD RRQLEQLTGE FYTVIPHDFG FKKMREFIID TPQKLKAKLE MVEALGEIEI 

       430        440        450        460        470        480 
ATKLLEDDST DQDDPLYARY KQLSCDFTPL EVGSEEYSMI KTYLANTHGK THTSYTVDVV 

       490        500        510        520        530        540 
QIFKVSRHGE MERFQKFATA GNRMLLWHGS RLTNWAGILS QGLRIAPPEA PVTGYMFGKG 

       550        560        570        580        590        600 
VYFADMFSKS ANYCYASEAC RSGVLLLCEV ALGEMNELLN ADYDANNLPK GKLSTKGVGQ 

       610        620        630        640        650        660 
TEPNTAESKI TDDGVVVPLG KPKAEPSKRG SLLYNEFIVY NVDQIRMRYV LHVSFNFKKR 

« Hide

References

« Hide 'large scale' references
[1]"The genome sequence and structure of rice chromosome 1."
Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y., Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H., Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M. expand/collapse author list , Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M., Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T., Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S., Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H., Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y., Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S., Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y., Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S., Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H., Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.
Nature 420:312-316(2002) [PubMed: 12447438] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[2]"The map-based sequence of the rice genome."
International rice genome sequencing project (IRGSP)
Nature 436:793-800(2005) [PubMed: 16100779] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Nipponbare.
[3]"The rice annotation project database (RAP-DB): 2008 update."
The rice annotation project (RAP)
Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed: 18089549] [Abstract]
Cited for: GENOME REANNOTATION.
Strain: cv. Nipponbare.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP003258 Genomic DNA. Translation: BAD52929.1. Sequence problems.
AP003764 Genomic DNA. Translation: BAD53855.1. Sequence problems.
AP008207 Genomic DNA. Translation: BAF04898.2. Sequence problems.
RefSeqNP_001042984.2. NM_001049519.2.
UniGeneOs.24852.

3D structure databases

HSSPHSSP built from PDB template 1GS0 based on UniProtKB O88554.
ProteinModelPortalQ5Z8Q9.
SMRQ5Z8Q9. Positions 3-40.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsLOC_Os01g24940.1; LOC_Os01g24940.1; LOC_Os01g24940.
GeneID4326479.
KEGGosa:4326479.

Organism-specific databases

GrameneQ5Z8Q9.

Phylogenomic databases

GeneTreeEPGT00070000029473.
OMACICDEDV.
PhylomeDBQ5Z8Q9.

Family and domain databases

InterProIPR012317. Poly(ADP-ribose)pol_cat_dom.
IPR004102. Poly(ADP-ribose)pol_reg_dom.
IPR003034. SAP_DNA-bd.
IPR008893. WGR_domain.
[Graphical view]
Gene3DG3DSA:1.10.720.30. G3DSA:1.10.720.30. 2 hits.
G3DSA:2.20.140.10. G3DSA:2.20.140.10. 1 hit.
G3DSA:1.20.142.10. PARP_reg. 1 hit.
KOK10798.
PfamPF00644. PARP. 1 hit.
PF02877. PARP_reg. 1 hit.
PF02037. SAP. 2 hits.
PF05406. WGR. 1 hit.
[Graphical view]
SMARTSM00513. SAP. 2 hits.
SM00773. WGR. 1 hit.
[Graphical view]
SUPFAMSSF47587. PARP_reg. 1 hit.
SSF142921. SSF142921. 1 hit.
PROSITEPS51060. PARP_ALPHA_HD. 1 hit.
PS51059. PARP_CATALYTIC. 1 hit.
PS50800. SAP. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePRP2A_ORYSJ
AccessionPrimary (citable) accession number: Q5Z8Q9
Secondary accession number(s): Q0JMY0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: December 14, 2011
This is version 50 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Oryza sativa (rice)

Index of Oryza sativa entries and their corresponding gene designations

SIMILARITY comments

Index of protein domains and families